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Öğe Determination of whole genome expression differences in larynx cancers and clinical significance(NATURE PUBLISHING GROUP, 2018) Goktas, E.; Yildirim, M. S.; Ozturk, K.; Zamani, A. G.[Abstract not Available]Öğe Effectiveness of corticosteroids in otitis media with effusion: an experimental study(CAMBRIDGE UNIV PRESS, 2008) Yaman, H.; Ozturk, K.; Uyar, Y.; Gurbilek, M.Objective: The aim of the present study was to investigate the dose-related effectiveness of corticosteroids in the management of otitis media with effusion, by using the objective assessment techniques of tympanometry and cytokine measurement. Materials and methods: The eustachian tubes of 42 male rats were obstructed. Thirty-six subjects with effusion were randomly divided into three equal groups: controls; 0.5 mg/kg/day corticosteroid; and 1 mg/kg/day corticosteroid. Concentrations of interleukin-1 beta and tumour necrosis factor a in the middle-ear effusions were analysed using enzyme-linked immunosorbent assay. Results: An effusion occurred on the 14th post-operative day and was present on the 30th post-operative day in the control group. Otomicroscopic examination and tympanometric measurement showed an improvement in the intervention groups. There was a significant difference between both intervention groups and the control group for both interleukin-1 beta and tumour necrosis factor alpha concentrations (p < 0.01). However, there was no significant difference between the 0.5 mg/kg and the I mg/kg corticosteroid groups (p > 0.05). Conclusion: The study confirmed a short term beneficial effect of systemic steroids on resolution of otitis media with effusion in a rat model. Our results support the theory that corticosteroids significantly decrease concentrations of both interleukin-1 beta and tumour necrosis factor alpha. In our model, the 0.5 mg/kg corticosteroid dose was as effective as the 1 mg/kg corticosteroid dose. Further studies should be carried out to determine the optimal dose and duration of corticosteroids in the treatment of otitis media with effusion.Öğe Evaluation of upper oesophageal sphincter in unilateral vocal fold paralysis(CAMBRIDGE UNIV PRESS, 2019) Erdur, O.; Gul, O.; Ozturk, K.Objective To evaluate dysphagia and manometric changes in the upper oesophageal sphincter in patients with unilateral vocal fold paralysis. Methods Thirty patients with unilateral vocal fold paralysis due to vagal nerve paralysis scheduled for evaluation were enrolled in the study group; 24 healthy subjects were included in the control group. Upper oesophageal sphincter basal and residual pressure, relaxation time, and pharyngeal pressure values were evaluated by manometry. All patients completed the Turkish Eating Assessment Tool 10 questionnaire, the MD Anderson dysphagia questionnaire and the reflux symptom index form. Results Swallowing assessment questionnaires and reflux symptom index results were significantly higher in the study group. Upper oesophageal sphincter basal and relaxation pressures were lower in the study group. Upper oesophageal sphincter relaxation time was shorter in the study group, but pressure values recorded from the pharynx were higher. Conclusion Upper oesophageal sphincter manometric pressure was lower in patients with unilateral vocal fold paralysis. A hypotonic sphincter likely contributes to dysphagia and aspiration.Öğe Feasibility of a septal mucosal flap for preventing re-stenosis following the draf III procedure(CAMBRIDGE UNIV PRESS, 2018) Erdur, O.; Ozturk, K.; Erkan, K.Background: Re-stenosis and a consequent need for revision surgery are the most common problems in the follow-up period following endoscopic modification of the Lothrop procedure. Method: This paper reports a new technique for reconstructing and resurfacing of the posterior frontal recess bone for prevention of re-stenosis. Results: A 46-year-old man presented with a frontal sinus osteoma, and treatment featured an endoscopic modification of the Lothrop procedure. A vascularised, posteriorly based, septal mucosal flap was used in reconstruction. There have been no reported issues over 24 months of follow up. Conclusion: The use of a nasoseptal flap seems feasible to reduce scarring and recurrence of (common) frontal recess stenosis after a Draf III operation.Öğe Reconstruction of condyles by transport distraction osteogenesis: 3 case report with complication management(ELSEVIER SCIENCE BV, 2018) Dolanmaz, D.; Ozturk, K.; Ilik, M. B.; Celik, M.Objective: The aim of this case report is to evaluate the clinical outcomes that including minor postoperative complications of the transport distraction osteogenesis (TDO) for reconstruction of the ramus-condyle unit. Study design: We present 3 cases of the ramus-condyle unit reconstruction after the resection of bone tumors. All three bone tumors were excised intraoperatively and the histologic assessment confirmed the clinical diagnosis of osteochondroma, condylar hyperplasia, and osteoma. Results: Although postoperative minor complications were noted; all patients had satisfactory lateral and protrusive jaw movements, and also adequate mouth openings. Conclusion: TDO for reconstruction of the ramus-condyle unit is an effective treatment modality for TMJ reconstruction. However, after condylectomy with resection of the condylar neck, it seems to be a reliable approach to adjust the distraction vector slightly posterior to maintain the transport segment in glenoid fossa to prevent the premature contact of bony segments, especially for individuals who have shorter anteroposterior ramus length in the axial plane. (C) 2018 Elsevier Masson SAS. All rights reserved.Öğe The use of adjunctive topical mitomycin in endoscopic congenital choanal atresia repair(ELSEVIER IRELAND LTD, 2010) Bozkurt, M. K.; Keles, B.; Azimov, A.; Ozturk, K.; Arbag, H.Objective: To evaluate the efficacy of topical mitomycin in providing the patency of the neochoanae in children undergoing transnasal endoscopic congenital choanal atresia (CA) repair. Methods: A retrospective analysis of surgical results in CA patients who were treated in Selcuk University, Meram Medical Faculty, Department of Otolaryngology between November 2002 and November 2009 was performed. All patients underwent transnasal endoscopic approach using nasal telescopes and traditional sinus instrumentation together with a microdebrider. Mitomycin was used according to the senior surgeon's preference, and certainly not in a randomized fashion. After completion of surgery, mitomycin 0.4 mg/ml was applied to the neochoanae for 3 min. Postoperative stenting was performed in all patients. Results: CA was unilateral in 8 subjects (mean age 71.8 +/- 41.7 months; range 18 months-144 months) and bilateral in 12 subjects (mean age 4.6 +/- 1.3 days; range 3-7 days). Among the subjects, 75% was female in both groups. Fourteen subjects under endoscopic repair without mitomycin, whereas mitomycin was used in 6 patients (4 bilateral, 2 unilateral). Stents were left at least 3 weeks postoperatively (mean 31 +/- 10 days; range 21-45 days). The patients were followed-up at least 6 months (range 6-72 months). No symptomatic restenosis requiring further dilatations was seen in patients treated with preoperative mitomycin, whereas restenosis was detected in 6 subjects (42.9%) treated without mitomycin postoperatively within 6 months period (Fisher's Exact Test 2-sided, p = 0.12). These subjects underwent revision endoscopic repair with mitomycin and had no need for further dilatations with acceptable control of symptoms during a follow-up period ranging between 14 and 78 months. Conclusion: Mitomycin improves the surgical treatment outcome of CA and reduces the rate of restenosis significantly without any complications. However, further prospective randomized studies are needed to fully investigate the benefits of mitomycin therapy in CA surgery. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
