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Öğe An investigation on failed or damaged reinforced concrete structures under their own-weight in Turkey(PERGAMON-ELSEVIER SCIENCE LTD, 2007) Kaltakci, M. Y.; Arslan, M. H.; Korkmaz, H. H.; Ozturk, M.In Turkey, more than 90% of building stock consists of reinforced concrete buildings. The majority of Turkey's urban population lives in multi-story apartment blocks constructed with reinforced concrete. In addition to reinforced concrete structure damages caused from especially last decade's earthquakes, there were built structures most of which are unable to carry their own-weight and are not appropriate to engineering and design criteria because of lack of interest, ignorance, lack of inspection and supervision in Turkey. Up to now, even though there are many examples, Turkey has faced two painful experiences in Diyarbakir Hicret Apartment totally collapsed in 1983 and caused significant casualties (93 dead) and in Konya Zumrut Apartment in 2004 (92 dead). The casualties in these phenomenons were more than some big earthquakes. The most significant disadvantage of reinforced concrete buildings is that after producing RC members abolishing detailing defaults cannot be possible. Except for structural damages caused from last big earthquakes, the existence of some RC buildings damaged due to their own-weight and static loading rises a necessity of control and rehabilitation of RC buildings. In the study, first of all, there is mentioned about the causes of structural damages like not obeying the standard criteria, workmanship faults, over design loads (change in the utilization purpose of the building), insufficient material quality and false revisions applied on the construction by the users. The effect of not considering the significant and fundamental criteria existing especially in TEC-98 and TBC-500-2000 on system behavior is examined. Afterwards, giving examples for reinforced concrete structures failed in a 10-year period of time only under its dead load and caused serious life and possession losses, various analyses and experimental studies related with those structures is presented. The samplings will be classified according to the locations of the damages occurred in load-bearing system members. Finally, at the end of the study, damage formation causes and necessary precautions will be specified according to the results obtained from the analytical and experimental data. (C) 2006 Elsevier Ltd. All rights reserved.Öğe Pantoprazole may improve beta cell function and diabetes mellitus(SPRINGER, 2014) Inci, F.; Atmaca, M.; Ozturk, M.; Yildiz, S.; Koceroglu, R.; Sekeroglu, R.; Ipekci, S. H.Background Proton pump inhibitors induce hypergastrinemia by suppressing gastric acidity. Gastrin has incretin-like stimulating actions on beta cells. Proton pump inhibitors have been shown to decrease glycosylated hemoglobin. Aim We aimed to observe changes in beta cell function in diabetic and non-diabetic subjects given pantoprazole for an acid-related ailment. Methods Seventy-nine male patients (38 non-diabetic and 41 type-2 diabetic receiving only metformin therapy) were followed for 12 weeks after pantoprazole 40 mg/day was given. Fasting plasma glucose, HbA1c, fasting insulin, Pancreatic B cell function (HOMA-B), proinsulin and c-peptide levels were measured before and after the treatment. Results In non-diabetic patients (n = 38), FPG decreased, whereas c-peptide, log-HOMA-B, increased significantly (p = 0.002, p = 0.03, p = 0.042, respectively) after 12 weeks of pantoprazole administration. In type 2 diabetic patients, FPG, HbA1c and weight decreased, whereas log-HOMA-B, c-peptide and log-proinsulin levels increased significantly after pantoprazole treatment (p = 0.003, p = 0.007, p < 0.001; p < 0.001; p = 0.017, p = 0.05, respectively). After pantoprazole treatment, pancreatic B-cell function was correlated with c-peptide and insulin and inversely with FBG and HbA1c levels in the whole group (r = 0.37, p = 0.001; r = 0.60, p < 0.001, r = -0.29, p = 0.011 and r = -0.28, p = 0.013, respectively). After pantoprazole treatment, HbA1c was correlated with FBG (r = 0.75, p < 0.001) and inversely with only log-HOMA-B level (r = -0.28, p = 0.013). Conclusions Pantoprazole administration seems to correlate with increased beta cell function. Pantoprazole administration improves HbA1c, HOMA-B, c-peptide and proinsulin levels. Since beta cell loss plays a significant role in the pathogenesis of type 2 diabetes, PPI-based therapies may be useful in the treatment of diabetes.Öğe Pharmacokinetics of florfenicol in the plasma of Japanese quail(NEW ZEALAND VETERINARY ASSOC INC, 2009) Koc, F.; Uney, K.; Ozturk, M.; Kadioglu, Y.; Atila, A.AIM: To determine the pharmacokinetics and bioavailability of florfenicol in the plasma of healthy Japanese quail (Coturnix japonica). METHODS: Sixty-five quail were given an I/V and I/M dose of florfenicol at 30 mg/kg bodyweight (BW). A two-period sequential design was used, with a wash-out period of 2 weeks between the different routes of administration. Concentrations of florfenicol in plasma were determined using high-performance liquid chromatography (HPLC). RESULTS: A naive pooled data analysis approach for the plasma concentration-time profile of florfenicol was found to fit a non-compartmental open model. After I/V administration, the mean residence time (MRT), mean volume of distribution at steady state (V(ss)), and total body clearance of florfenicol were 12.0 (SD 0.37) h, 8.7 (SD 0.22) L/kg, and 1.3 (SD 0.08) L/h/kg, respectively. After I/M injection, the MRT, mean absorption time (MAT), and bioavailability were 12.3 (SD 0.37) h, 0.2 (SD 0.02) h, and 79.1 (SD 1.79)%, respectively. CONCLUSIONS: The time for the concentration of florfenicol to fall below the probable effective concentration of 1 mu g/ml of approximately 10 h is sufficient for the minimum inhibitory concentration needed for many bacterial isolates. Further pharmacodynamic studies in quail are needed to evaluate a suitable dosage regimen.
