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Öğe Acquired ocular motor apraxia from bilateral frontoparietal infarcts associated with Takayasu arteritis(B M J PUBLISHING GROUP, 2004) Genç, Bülent Oğuz; Genç, Emine; Açık, Leyla; İlhan, S.; Paksoy, Yahya[Abstract not Available]Öğe An aggressive parameningeal rhabdomyosarcoma with multiple spinal cord metastases: a case report and review of the literature(SPRINGER, 2017) Yavas, Guler; Karabagli, Pinar; Paksoy, Yahya; Yavas, Cagdas; Karabagli, Hakan; Koksal, YavuzPurpose Spinal cord metastasis from rhabdomyosarcoma (RMS) is extremely rare, with three cases reported to date. Herein, we report an aggressive case of RMS of the infratemporal fossa who which developed spinal cord metastases during treatment. Case presentation A 6-year-old girl presented with an enlarging painless mass around her right ear for 3 months. An enhanced magnetic resonance imaging (MRI) revealed a 5 x x4 x x4.5 5 cm mass on her right infratemporal fossa. A tru-cut biopsy was performed, and histopathologic examination revealed the diagnosis of rhabdomyosarcoma. At the time of the diagnosis, cerebrospinal fluid cytology was negative for malignant cells. The patient underwent induction chemotherapy. There was minimal response to chemotherapy, and the patient underwent curative radiotherapy. However, by 12th fraction of RT, the patient developed a progressive weakness on her lower extremity. Spinal MRI revealed multiple gross masses in different parts of the spinal cord. The local radiotherapy was changed toas craniospinal radiotherapy. However, two 2 weeks after the completion of the RT, the patient developed sepsis and expired because of septic shock. Conclusion Parameningeal RMS is a peculiar subgroup of RMS, which needs an aggressive approach. Despite aggressive approach, meningeal spread is the most important cause of the treatment failure. We should keept in mind that during the treatment, there can be meningeal spread towards to either the brain or spinal cord; therefore, we should follow -up the patients closely from this aspect.Öğe Anterior Spinal Artery Aneurysm Presenting With Spinal Cord Compression: MRI and MRI Angiographic Findings(B M J Publishing Group, 2010) Koç, Osman; Özbek, Orhan; Paksoy, Yahya; Kocaoğulları, YalçınA 30-year-old woman presented with progressive paraparesis and urinary incontinence for 1 month. Physical examination revealed weakness at the plantar and dorsal flexors of the ankle and toes. Routine blood tests were normal. MRI showed spinal cord compression.Öğe Application of first-pass contrast bolus tracking sequence for the assessment of morphology and flow dynamics in cardiac MRI(AVES, 2013) Paksoy, Yahya; Ozbek, Orhan; Gumus, Serter; Koc, Osman; Nayman, Alaaddin; Kerimoglu, UlkuPURPOSE There are two well-known indications for first-pass perfusion in the literature. First is the evaluation of Myocardial ischemia, and the other is the evaluation of tumor vascularity. Our aim was to assess the value of a first-pass Contrast bolus tracking sequence (FPCBTS) for cases unrelated to these pathologies. MATERIALS AND METHODS A total of 35 patients (age range, 1 day to 66 years; mean age, 10.4 +/- 19.2 years; median age, 4.5 months) with suspected congenital (n=31) and acquired (n=4) heart and great vessel disease Were included in the study. All the patients underwent cardiac magnetic resonance imaging (MRI) and FPCBTS, and 20 patients underwent contrast enhanced magnetic resonance angiography (CE-MRA). We used cardiac MRI and CE-MRA for anatomic evaluation and FPCBTS for dynamic flow evaluation. RESULTS Truncus arteriosus, double outlet right ventricle, tetralogy of Fallot; corrected transposition of great arteries, atrial and ventricular septal defect, aortic rupture, cardiac hydatid cyst, tricuspid atresia, anomalous pulmonary venous return; and interrupted aorta were detected using the technique described here. Septal defects in six patients arid atrial aneurysm in two patients were excluded. The shunt gap and flow direction of the septal defects, a ruptured Wall in a dissected aorta, a hydatid cyst, and the atrial relationship in two cases with paracardiac masses Were diagnosed easily using this dynamic evaluation technique. CONCLUSION FPCBTS Can be performed in addition to cardiac MRI and CE-MRA to reveal flow dynamics and morphology.Öğe Astroblastoma in a child(SPRINGER, 2008) Unal, Ekrem; Koksal, Yavuz; Vajtai, Istvan; Toy, Hatice; Kocaogullar, Yalcin; Paksoy, YahyaBackground Astroblastoma, an uncommon neuroepithelial tumor, typically presents in young adults as a well-circumscribed cortical or subcortical spherical mass. Astroblastoma may cause a diagnostic problem to anyone unfamiliar with its architectural and histological features. Case history We report the case of a 4-year-old boy who was referred for complaints of progressive deficits of balance and difficulty with walking during the previous 3 months. A large fronto-parietal cystic mass with solid mural nodule was discovered. Total removal of the tumor mass was performed, and a diagnosis of high grade (malignant) variant of astroblastoma was made. Postoperatively, the patient received radiation therapy, for a period of 11 weeks, followed by chemotherapy. He is in a good neurological recovery without any evidence of recurrence for 8 months. Prognosis The best treatment modality for astroblastoma is surgical resection if possible, whereas adjuvant therapy (radiotherapy and/or chemotherapy) can be considered in high-grade astroblastomas, with a close follow-up for all cases.Öğe An atypical isolated CNS blast crisis in chronic myeloid leukaemia(MA HEALTHCARE LTD, 2018) Sivri, Mesut; Paksoy, Yahya; Dagli, Mehmet; Kelesoglu, Kazim Serhan; Koplay, Mustafa[Abstract not Available]Öğe Autologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardium(Mary Ann Liebert, Inc, 2010) Tokaç, Mehmet; Aktan, Murad; Ak, Ahmet; Duman, Selçuk; Tokgözoğlu, Lale; Aygül, Nazif; Paksoy, Yahya; Porat, YaelCellular cardiomyoplasty is a promising approach for the treatment of severe heart failure. However, the question which cell line is the best to use is still a matter of debate. In this study, we aimed to evaluate the efficacy of arterial media-intima cell suspension (AMICS) transplantation in rabbit myocardial infarct model. The study was divided into 2 groups: group A (the cell-treated group, n = 9) and group B (the medium injection group, n = 8). Group A was further divided into 2 subgroups as branch-1 (treated with unlabeled cells) and branch-2 (treated with iron-labeled cells). The experimental myocardial infarction (MI) was induced by ligation of left anterior descending coronary artery with a combination of cryoinjury. Ten days after the MI, cells obtained from autologous femoral arteries were injected into the injured myocardium of group A, while group B received an injection of only DMEM medium. Clinical, echocardiographic, and histopathologic evaluations were done. As compared to the ninth day values, echocardiography showed a significant improvement in systolic functions and left ventricular (LV) dimensions of the cell-treated group on the 30th day. In the heart biopsy sections of branch-1, the immunostained injected cells were observed to exist closely, suggesting an organization. Cells existing separately and lumen-like structure organizations stained positive with both smooth muscle cell (SMC) a-actin and Prussian Blue were also showed in the histological observation of branch-2. Autologous AMICS transplantation seems to be a feasible and efficacious method for cellular cardiomyoplasty in our rabbit model.Öğe Behçet hastalığında iyatrojenik sağ internal mamaryan arter çalma sendromu(2014) Erol, Cengiz; Paksoy, Yahya; Kanat, Fikret; Özbek, Seda; Kıvrak, A.Sami; Koplay, Mustafa; Özbek, OrhanSubklaviyan arter anevrizması nedeniyle opere edilen bir Behcet olgusunda anevrizmaya açılan vertebral arter ve sağ internal mamaryan arterin, anevrizma kesesi içerisinde bırakılması sonucu, post operatif dönemde iatrojenik olarak ortaya çıkan sağ internal mamaryan arter çalma sendromunun görüntüleme bulgularını sunmak istedik. Bizim bilgilerimize göre bugüne kadar, sağ internal mamaryan arterin sorumlu olduğu çalma sendromu literatürde tariflenmemiştir. Kesitsel noninvaziv radyolojik görüntüleme yöntemleri, bu olguda anatomik detayın gösterilmesi, cerrahi sonrası değişen ve yeni ortaya çıkan anatominin ortaya konmasında oldukça başarılı olmuştur.Öğe Bilateral Putaminal and Optical Involvement After Low Dose of Methanol Exposure: Case Report(2012) Tokgöz, Osman Serhat; Güney, Figen; Kamiş, Ümit; Paksoy, YahyaMethanol is a toxin with rare but serious effects on the central nervous system. It may cause severe visual dysfunction and mortality. This study presents the case of a 44-year-old man admitted to our clinic with bilateral amaurosis which developed after dental intervention for gingivitis. The patient was conscious and presented with stomach ache, nausea, vomiting, weakness, imbalance, and bilateral amaurosis; methanol poisoning was diagnosed. Upon examination, the absence of light perception in the eye and bilateral weakness in light reflexes were detected. Visually-evoked potentials (P100) could not be obtained. Hyper-intense lesions with bilateral putaminal localisation were observed on magnetic resonance imaging and bilateral pupil oedema was observed by fundus photography. The patient was treated with methyl prednisolone and intravenous vitamin B1. On the fifth day after admission, fluctuations in visual findings were observed, and light reflex loss and pupillary dilatation developed. Upon examination one and six months later, bilateral (total) amaurosis and bilateral optic atrophy were detected. This case demonstrates bilateral putaminal involvement after exposure to a very low dose of methanol.Öğe Bilateral putaminal and optical involvement after low dose of methanol exposure: Case report(2012) Tokgöz, Osman Serhat; Güney, Figen; Kamış, Ümit; Paksoy, YahyaMetanol nadir fakat ciddi santral sinir sistemi etkileri olan bir toksindir. Ağır görme bozuklukları ve ölüme neden olabilir. Bu yazıda ispirto ile diş pansumanı sonrasında gelişen bilateral total görme kaybı nedeniyle kliniğimize başvuran 44 yaşın- da bir erkek hasta sunuldu. Pansumandan sonra gelişen ka- rın ağrısı, bulantı, kusma, halsizlik, dengesizlik ve iki taraflı görme kaybı şikayetleri ile metanol intoksikasyonu tanısı alan hastanın bilinci açıktı. Muayenesinde gözde ışık persepsiyonu yokluğu ve ışık refleksinde bilateral zayıflık belirlendi. Görsel uyarılmış potansiyel (P100) elde edilemedi. Manyetik rezo- nans görüntülerinde bilateral putamen lokalizasyonunda hipe- rintens lezyonlar ve fundus fotoğrafında bilateral papil ödemi izlendi. Hastaya metil prednizolon ve intravenöz B1 vitamin tedavisi verildi. Görme bulgularındaki dalgalanmaları takiben beşinci günde ışık refleksi kaybı ve pupilla dilatasyonu gelişti. Birinci ve altıncı aylardaki muayenesinde total görme kaybı ve bilateral optik atrofi tespit edildi. Oldukça düşük doz metanol maruziyeti sonrası bilateral putaminal tutulumu olduğunu gös- termesi açısından örnek bir vakadır.Öğe Bir çocukta serebellumun disembriyoplastik nöroepiteliyal tümörü(2014) Köse, Doğan; Kalkan, Erdal; Paksoy, Yahya; Toy, Hatice; Ergün, Nurcan Üçüncü; Köksal, YavuzDisembriyoplastik nöroepitelyial tümörler (DNT) tipik olarak supratentorial yerleşen benign neoplazmalardır. Bilinç ve postural tonus kaybı şikayetleri ile bir lokal hastaneye başvuran 12 yaşındaki erkek hasta saptanan serebellar kitlesi nedeniyle hastanemize refere edildi. Hikayesinden benzer şikayetlerinin 3 ve 10 yaşlarında da tekrar ettiği ancak o dönemde pediatric kardiyolog ve pediatric nörolog tarafından yapılan incelemelerde herhangi bir anomaliye rastlanmadığı öğrenildi. Hastanın fizik muayenesi ve rutin laboratuvar tetkikleri normaldi. Serebellumda saptanan kitle total olarak çıkarıldı. Alınan dokunun histopatolojik değerlendirmesi ile hastaya DNT tanısı konuldu. Hasta halen, 5 yıldır, herhangi bir nüks belirtisi olmadan ayaktan takip edilmektedir. Bu yazıda serebellum yerleşimli DNT'ye sahip bir çocuk vakanın literatürle paylaşılması amaçlanmıştır.Öğe Bir Testiküler Mikrolitiyazis Olgusu(1997) Paksoy, Yahya; Perktaş, Süleyman; Açıkgözoğlu, Saim; Ödev, Kemal; Alagöz, FatmaAmaç: Testiküler mikrolitiyazis, karakteristik sonografik bulguları olan nadir bir durum olduğundan, testiküler mikrolitiyazisli bir olguda sonografik bulguları sunduk. Olgu sunumu: 22 yaşında, infertilite hikayesi ve varikosel ön tanısı olan erkek olguda sonografide her iki testisin normal büyüklükte ve ekojenitede olduğu gözlendi. Her iki testiste, diffüz olarak dağılmış gölge vermeyen hiperekoik odaklar vardı. Sonuç: TM’in sonografik görünümü spesifiktir ve bu olgularda biyopsi ve orşiyektomi gereksizdir. Bununla birlikte son zamanlarda, tümör gelişme ihtimalinin yüksek olduğunu belirten yayınlar vardır ve sık aralıklarla sonografik olarak ve serum tümör markerleri ile takip edilmesi önerilmektedir.Öğe Cardiovascular MR imaging findings of total anomalous pulmonary venous connection to the portal vein in a patient with right atrial isomerism(SPRINGER WIEN, 2012) Koplay, Mustafa; Paksoy, Yahya; Erol, Cengiz; Arslan, Derya; Kivrak, Ali Sami; Karaaslan, SevimTotal anomalous pulmonary venous connection (TAPVC) is a rare congenital cardiovascular anomaly in which the pulmonary veins fail to join to the left atrium and drain directly to the right atrium or to one of the systemic veins. This anomaly is frequently seen together with complex cardiac anomalies especially as a part of right atrial isomerism syndrome. Atrial isomerism is called that the same morphological structure of both atria. We reported a very rare case demonstrating TAPVC between the portal vein and the pulmonary veins in a patient with right atrial isomerism by magnetic resonance imaging.Öğe Cerebral venous sinus thrombosis in an adolescent with Ewing sarcoma(SPRINGER, 2008) Unal, Ekrem; Yazar, Abdullah; Koksal, Yavuz; Caliskan, Umran; Paksoy, Yahya; Kalkan, ErdalBackground Although thromboembolic complications are common in adult patients with malignant diseases, cerebral venous sinus thrombosis has been rarely described in cancer afflicted pediatric and adolescent population. Case history A 16-year-old adolescent girl referred for complaints of pain and swelling on her left leg. On physical examination, a solid tibial mass was discovered. After the diagnosis of Ewing sarcoma with a tru-cut biopsy, chemotherapy protocol consisting of cisplatin, ifosfamide, adriamycine, and vincristine was started. During the first course of the treatment, the patient expressed headache, diplopia, and ptosis. Contrast-enhanced magnetic resonance (MR) images and MR angiography showed superior sagittal and transverse sinus thromboses. After anticoagulant therapy, the thromboses disappeared within 1.5 months. She received her chemotherapy protocol with the anticoagulant prophylaxis. After a follow-up period of 12 months, she is still in a good neurological recovery without any sequel. Conclusion Children and adolescents with cancer should be monitored closely for thrombotic complications. We discuss this uncommon case to draw attention to the importance of early diagnosis and adequate treatment of intracranial thrombosis in childhood cancer, and we review the relevant literature.Öğe Cervical giant pseudomeningocele presented with neck pain: conventional MRI and MR myelography findings(ELSEVIER SCIENCE INC, 2016) Cebeci, Hakan; Koplay, Mustafa; Sivri, Mesut; Paksoy, Yahya[Abstract not Available]Öğe Comparison of apparent diffusion coefficient values among different MRI platforms: a multicenter phantom study(AVES, 2013) Kivrak, Ali Sami; Paksoy, Yahya; Erol, Cengiz; Koplay, Mustafa; Ozbek, Seda; Kara, FatihPURPOSE We aimed to compare apparent diffusion coefficient (ADC) values among magnetic resonance imaging (MRI) scanners from different vendors. MATERIALS AND METHODS We used a custom-made phantom solution consisting of distilled water, 0.9% NaCl, 25% NaCl, and shampoo for diffusion-weighted MRI (DW-MRI) examinations. DW-MRI was performed with similar sequence parameters using six different 1.5 Tesla MR scanners (scanners A F). ADC maps were automatically constructed for all DW-MR images (b factors of 0 and 1000 s/mm(2)). ADC measurements were performed using regions of interest and seven different software programs, including four different postprocessing workstations, two different picture archiving and communication systems, and operator console software for each MR scanner. RESULTS The ADC values generated by scanners A and F were higher and those of scanner B were lower than those generated by the other scanners (P = 0.002). The intravendor difference in the ADC values averaged from scanners D, E, and F was statistically significant (P < 0.001). The difference between the ADC values obtained by scanners C and E was not statistically different (P = 0.15). CONCLUSION ADC values may differ among different MRI systems used for DW-MRI. Thus, the MRI vendor should be considered when using DW-MRI in a clinical setting.Öğe Congenital Aortopulmonary Fistule: Multislice CT Angiography Findings(2009) Özbek, Orhan; Koç, Osman; Paksoy, Yahya; Gümüş, Serter; Karaaslan, SevimAortopulmonary fistulas are most commonly reported as a complication of thoracic surgery or aortic dissection. Formation of congenital fistula between aorta and main pulmonary artery without an accompanying congenital malformation has not been reported yet. A patient who had a milimetric tortuous vascular structure between descending aorta and main pulmonary artery on CT angiography and diagnosed as congenital aortopulmonary fistula and attempted to our hospital with dyspnea, is reported. The aim of this report is to demonstrate aortopulmonary fistula in the multislice CT images and to emphasize considering the aortopulmonary fistula in the differential diagnosis of left to right shunt. © 2009 Elsevier Ireland Ltd. All rights reserved.Öğe Congenital left ventricular wall abnormalities in adults detected by gated cardiac multidetector computed tomography: Clefts, aneurysms, diverticula and terminology problems(ELSEVIER IRELAND LTD, 2012) Erol, Cengiz; Koplay, Mustafa; Olcay, Ayhan; Kivrak, Ali Sami; Ozbek, Seda; Seker, Mehmet; Paksoy, YahyaObjectives: Our aim was to evaluate congenital left ventricular wall abnormalities (clefts, aneurysms and diverticula), describe and illustrate imaging features, discuss terminology problems and determine their prevalence detected by cardiac CT in a single center. Materials and methods: Coronary CT angiography images of 2093 adult patients were evaluated retrospectively in order to determine congenital left ventricular wall abnormalities. Results: The incidence of left ventricular clefts (LVC) was 6.7% (141 patients) and statistically significant difference was not detected between the sexes regarding LVC (P = 0.5). LVCs were single in 65.2% and multiple in 34.8% of patients. They were located at the basal to mid inferoseptal segment of the left ventricle in 55.4%, the basal to mid anteroseptal segment in 24.1%, basal to mid inferior segment in 17% and septal-apical septal segment in 3.5% of cases. The cleft length ranged from 5 to 22 mm (mean 10.5 mm) and they had a narrow connection with the left ventricle (mean 2.5 mm). They were contractile with the left ventricle and obliterated during systole. Congenital left ventricular septal aneurysm that was located just under the aortic valve was detected in two patients (0.1%). No case of congenital left ventricular diverticulum was detected. Conclusion: Cardiac CT allows us to recognize congenital left ventricular wall abnormalities which have been previously overlooked in adults. LVC is a congenital structural variant of the myocardium, is seen more frequently than previously reported and should be differentiated from aneurysm and diverticulum for possible catastrophic complications of the latter two. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Öğe Congenital morphological abnormalities of the distal vertebral arteries (CMADVA) and their relationship with vertigo and dizziness(INT SCIENTIFIC INFORMATION, INC, 2004) Paksoy, Yahya; Vatansev, Hüsamettin; Şeker, Muzaffer; Üstün, Mehmet Erkan; Büyükmumcu, Mustafa; Akpınar, ZehraBackround: The aim of our study was to identify congenital morphological abnormalities of distal vertebral arteries (CMADVA) and their association with cerebral hypoperfusion leading to vertigo, and the role of MR and MRA in the diagnosis of vertebrobasilar (VB) abnormalities. Materials/Methods: 768 patients who complained of dizziness and/or vertigo were included in the study and evaluated by MR and MRA. CMADVAs were determined in 88 of the cases with no other explanation for vertigo and dizziness. 150 patients without dizziness or vertigo were used as a control group. The 3D TOF (Time-of-flight) MR angiographic technique was used. Results: CMADVAs were detected in 88 of 768 patients (11.5%) with vertigo and/or dizziness. We also detected CMADVAs in 4 (2.7%) of 150 persons in the control group. The patients with abnormal vertebral artery findings were classified into ten categories. Lacunar infarcts in the brain stem were found in 8 patients after long-duration vertigo attacks. There was significant correlation between the control and vertigo groups in terms of CMADVA (p=0.0001). After excluding the control group, there was a significant relationship between CMADVA and vertigo and/or dizziness symptoms (P=0.0001). Conclusions: We believe that vertigo and dizziness associated with CMADVA is a real entity that deserves greater attention. For this reason, the vertebrobasilar system in these patients should be examined for CMADVA with MRA. This would enable us to take preventive measures against brainstem ischemia or at least elucidate the etiology of vertigo in these patients.Öğe Developmental Anomalies of Bronchial Tree: A Multidetector Computerized Tomography Study(SOC CHILENA ANATOMIA, 2013) Ulusoy, Mahinur; Kivrak, Ali Sami; Uysal, Ismihan Ilknur; Karabulut, Ahmet Kagan; Paksoy, Yahya; Fazliogullari, ZelihaAnomalies of the bronchial tree may cause recurrent acute pulmonary infection and persistent obstruction symptoms. The developmental anomalies of the bronchial tree were presented mostly as case reports with an accompanying anomaly. However in this study, these anomalies were detected in multidetector computerized tomography (MDCT) images which have no reported pathology. Thoracic MDCT images of 400 patients (0-74 years old, 224 male and 176 female) were evaluated. Four tracheal bronchus (1%) were detected. Three of them were displaced type, one of them was pig bronchus. And two accessory cardiac bronchus (0,5%) originated from medial wall of the intermediate bronchus were detected. According to our findings, incidence of tracheal bronchus and accessory cardiac bronchus seems to be higher in Turkish population.