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Öğe Anti-Mullerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer(INFORMA HEALTHCARE, 2015) Dogan, N. U.; Kerimoglu, O. S.; Karabagli, P.; Pekin, A.; Yilmaz, S. A.; Incesu, F.; Celik, C.Our aim was to evaluate serum levels of anti-Mullerian hormone (AMH) and also immunohistochemical (IHC) staining properties of AMH receptor type II (AMHRII) in patients with endometrial cancer (EC) and a control group. Preoperatively, serum levels of AMH were assessed and AMHRII expression was evaluated by immunohistochemistry in a benign and malignant group. AMH serum levels of the control group and EC patients were comparable. For EC patients, there was no difference with respect to the AMH levels and tumour stage; grade; histological type; deep myometrial invasion; lymphovascular space invasion or lymph node involvement. However, AMH levels in patients with extrauterine involvement were higher than patients with disease confined to the uterus. EC samples were more likely to be stained positive for AMHRII than benign lesions. Also, as the stage of the lesion worsens, the rate of IHC staining of AMHRII decreases. In conclusion, AMHRII is expressed in normal endometrial cells as well as endometrial cancer cells. AMH levels increase in EC, with extrauterine involvement at least in locally advanced disease. Also AMH expression decreases as the disease is staged-up.Öğe Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy(INFORMA HEALTHCARE, 2015) Kerimoglu, O. S.; Yilmaz, S. A.; Pekin, A.; Incesu, F.; Dogan, N. U.; Ilhan, T. T.; Celik, C.The aim of this prospective study was to investigate the effect of drainage on postoperative shoulder and abdominal pain after uncomplicated laparoscopic ovarian cystectomy (LOC). Allocation to drain or not to drain was non-randomised. There were 55 patients with drainage and 56 patients without drainage. Postoperative shoulder and abdominal pain was assessed using a 10-point visual analogue scale. Postoperative hospital stay in the drainage group was longer than the non-drainage group (p = 0.040). Postoperative shoulder pain scores at 6 h and 24 h were similar between the drainage and non-drainage groups (p = 0.376 and p = 0.847, respectively). Postoperative abdominal pain was higher in the drainage group at 6 h (p = 0.009), but was similar at 24 h (p = 0.097) between the groups. These data suggest that for LOC, drainage may not be useful to prevent postoperative shoulder pain and also increases postoperative abdominal pain and length of hospital stay.Öğe Effect of the FSH receptor polymorphism on the age at menarche(7847050 CANADA INC, 2019) Kerimoglu, O. S.; Pekin, A.; Yilmaz, S. A.; Incesu, F. N.; Nergiz, S.; Dogan, N. U.; Acar, H.Estrogen and estrogen receptor (ER) genes have an effect on the age at menarche. Follicle stimulating hormone (BID is an important hormone that plays a major role in the regulation of folliculogenesis and estrogen synthesis. The aim of this study was to investigate the influence of the FSH receptor (FSHR) polymorphisms Asn680Ser and Thr307Ala on age at menarche. Materials and Methods: FSH receptor gene polymorphisms were investigated in women who were admitted to Selcuk University between May 2013 and November 2014. Information about age at menarche was obtained through interviews. Polymorphic analysis of the FSH receptor gene was performed in 209 healthy female patients who had undergone an annual health examination. Genomic DNA was obtained from peripheral blood leukocytes, and polymorphisms were investigated using restriction fragment length polymorphism analysis. Results: The mean age at menarche was 12.95 +/- 1.62 years. The overall frequencies for Asn680Ser variants NN, NS, and SS were 40.2%, 36.4%, and 23.4%, respectively, whereas Thr307Ala variants TT, TA, and AA were 34.4%, 41.1%, and 24.4%, respectively. Menarche occurred 3.6 months earlier in subjects with TN homozygote genotype than in AS homozygotes, and the mean age at menarche was 2.5 months earlier in TN homozygotes compared with that in all other study subjects, but the differences were not statistically significant (p = 0.966 and p = 0.986, respectively). Conclusions: The Ala307Thr and Ser680Asn polymorphisms of the FSHR gene are not associated with age at menarche.Öğe Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome -- 2(OXFORD UNIV PRESS, 2014) Yilmaz, S. A.; Kerimoglu, O. Secilmis; Pekin, A.; Incesu, F.; Dogan, N. U.; Celik, C.; Unlu, A.[Abstract not Available]Öğe Pyometra in elderly post-menopausal women: a sign of malignity(I R O G CANADA, INC, 2015) Kerimoglu, O. S.; Pekin, A.; Yilmaz, S. A.; Bakbak, B. B. Gencoglu; Celik, C.Purpose: To describe the clinical and histopathological characteristics of 12 patients with pyometra and highlight the increased incidence of gynecological malignancy in these patients. Materials and Methods: The authors examined the medical records of 12 patients with pyometra, who were treated between 2009 and 2013. Results: All patients were post-menopausal, and their mean age was 70.83 6.978 years (min=61, max=82). To remove purulent fluid via dilation and because of the probability of malignancy, three patients (25%) underwent cervical biopsy and endometrial curettage; the other nine patients (75%) underwent curettage alone, with suitable antibiotic therapy. Of the 12 patients, nine (75%) had gynecologic malignancy [(endometrial cancer, n=5, 41.6%), (cervical cancer, n=3, 25%), (uterine leiomyosarcoma, n=1, 8.3%)]. In three (25%) patients, the cause of pyometra was benign pathologies, among which the most common were leiomyomas (n=2, 66.6%). Conclusion: Pyometra diagnosed during the post-menopausal period should be considered a complication caused by gynecological malignancy until proven otherwise.
