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    Plasma leptin levels increase to a greater extent following on-pump coronary artery surgery in type 2 diabetic patients than in nondiabetic patients
    (ELSEVIER IRELAND LTD, 2012) Guvener, Murat; Ucar, Halil Ibrahim; Oc, Mehmet; Pinar, Asli
    Aims: We aimed to evaluate whether leptin and ghrelin responses to cardiopulmonary bypass (CPB) are dependent on type 2 diabetes and whether these responses are associated with interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), cortisol and insulin. Methods: We examined stress-response patterns in plasma leptin, ghrelin, hsCRP, IL-6, cortisol and insulin levels before and up to 5 days after cardiopulmonary bypass in 20 patients with type 2 diabetes and 20 patients without diabetes. Results: Plasma leptin levels increased significantly in both groups (p < 0.05) and rose significantly higher in diabetics when compared with nondiabetic patients (p = 0.004). Plasma ghrelin levels increased significantly only in diabetics (p = 0.033). Patients with and without diabetes showed significantly elevated serum concentrations of IL-6, hsCRP, cortisol and insulin (p < 0.005 for IL-6, hsCRP; p < 0.05 for cortisol, insulin) but the difference between the two groups was nonsignificant. Leptin was independently predicted by hsCRP (p < 0.05, F = 2.9), gender (women p < 0.001, F = 4.7), body mass index (BMI p < 0.0001, F = 6.1) whereas ghrelin levels were not associated with any variables in the total patient population. (critical F = 2.26, p <= 0.05). Conclusions: Acute phase response in diabetics differs by higher leptin levels independent of BMI, gender and IL-6, hsCRP, insulin and cortisol levels. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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    Serum vitamin D deficiency and its association with systemic disease in exfoliation syndrome
    (SAGE PUBLICATIONS LTD, 2013) Kocabeyoglu, Sibel; Mocan, Mehmet Cem; Irkec, Murat; Pinar, Asli; Bozkurt, Banu; Orhan, Mehmet
    Purpose: To determine the association of serum vitamin D levels with exfoliation syndrome (XFS) and evaluate its impact on co-associated systemic diseases. Methods: Forty patients with XFS and 40 control subjects without XFS were recruited for this study Serum concentrations of 25-hydroxy vitamin D [25(OH) D] were measured by high-performance liquid chromatography Vitamin D deficiency was defined as a serum 25(OH) D concentration of <20 ng/mL. A detailed medical history including hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular stroke, autoimmune disease, and neurologic disorders such as Parkinson disease and Alzheimer disease was recorded. Student t test and chi-square test was used for statistical evaluations. Results: The mean age of patients with XFS and control subjects was 69.6 +/- 8.1 years (range 58-90 years) and 67.1 +/- 6.3 years (range 60-86 years), respectively (p>0.05). Mean 25(OH) D levels did not differ between XFS (19.8 +/- 8.3 ng/mL) and control (19.9 +/- 10.3 ng/mL) groups (p = 0.978). Patients with XFS had higher prevalence of cerebrovascular (p = 0.026) and cardiovascular disease (p = 0.001). There was no association between the systemic disease status and serum vitamin D levels of patients with XFS. Conclusions: Although vitamin D levels were similar between XFS and control subjects, the levels were found to be decreased in both groups. Patients with XFS had a significantly higher prevalence of cerebrovascular and cardiovascular disease as compared to controls independent of their serum 25(OH) D levels. Low vitamin D level does not appear to be linked to XFS in the studied population.