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Öğe Arterial spasm following perimesencephalic nonaneurysmal subarachnoid hemorrhage in a pediatric patient(ELSEVIER SCIENCE INC, 2005) Sert, A; Aydin, K; Pirgon, O; Emlik, D; Ustun, MEPerimesencephalic nonaneurysmal hemorrhage is a benign form of subarachnoid hemorrhages. This entity is well recognized as a distinct type of subarachnoid hemorrhage in adults. However, perimesencephalic nonaneurysmal subarachnoid hemorrhage in pediatric patients is not well recognized. Angiographic changes such as vasospasm are uncommon in patients, especially in pediatric patients suffering from this type of hemorrhage. This case study reports a 12-year-old male who suffered from perimesencephalic nonaneurysmal subarachnoid hemorrhage. Cerebral carotid angiography performed on the tenth day of the posthemorrhagic period revealed severe vasospasm affecting the basilar artery. The patient, treated symptomatically, was discharged after improvement. One year later, magnetic resonance angiography revealed completely normal features. (c) 2005 by Elsevier Inc. All rights reserved.Öğe Increased cardiac troponin I concentration in diabetic ketoacidosis(FREUND PUBLISHING HOUSE LTD, 2004) Atabek, ME; Pirgon, O; Oran, L; Erkul, I; Kurtoglu, SObjective: To examine the hypothesis that diabetic ketoacidosis may be associated with some degree of induced injury to heart muscle, related either to acidosis or hyperglycemia. Methods: Nineteen diabetic patients with acute ketoacidosis and 19 healthy children were enrolled in this study. Cardiac troponin I (cTnI), creatine kinase (CK)-MB and myoglobin levels were analyzed soon after admission and after 24 h. Patients were subdivided into two groups according to blood pH. Results: At the time of admission, the diabetic patients had significantly higher values than the controls for cTnI (0.193 +/- 0.008 vs 0.176 +/- 0.006 ng/dl; p < 0.001), CK-MB (24.1 < 2.1 vs 22.7 < 1.2 U/l; p = 0.02), and myoglobin (85.5 < 7.4 vs 52.5 +/- 8.3 mug/dl; p < 0.001). The diabetic patients also had significantly higher values than the controls for CK-MB (24 2.1 vs 22.7 +/- 1.2 U/l; p = 0.02) and for myoglobin (78.5 +/- 2.5 vs 52.5 +/- 8.3 mug/dl; p < 0.001) at 24 h. cTnI had normalized in patients at 24 h. All parameters were significantly different between patients with pH greater than or equal to7.0 and patients with pH <7.0. In addition, serum cTnI levels correlated negatively. with blood pH (r = -0.57, p = 0.026) and HCO3- (r = -0.65, p = 0.008) in the patients with diabetic ketoacidosis on admission. Conclusion: Our findings suggest that diabetic ketoacidosis, particularly when severe, has a detrimental effect on the myocardium.Öğe Oral alendronate therapy for severe vitamin D intoxication of the infant with nephrocalcinosis(FREUND PUBLISHING HOUSE LTD, 2006) Atabek, ME; Pirgon, O; Sert, AVitamin D intoxication is a well-known cause of hypercalcemia in children. We report here the use of oral alendronate for the treatment of hypercalcemia due to vitamin D intoxication in a 7 month-old infant with nephrocalcinosis. The serum calcium levels were normalized without complications. Oral alendronate therapy may be safely used in hypercalcemia due to vitamin. D intoxication in pediatric patients with nephrocalcinosis resistant to hydration, diuretics or corticosteroids.Öğe Plasma homocysteine levels in children and adolescents with type 1 diabetes(INDIAN ACADEMY PEDIATRICS, 2006) Atabek, ME; Pirgon, O; Karagozoglu, EObjective: Hyperhomocysteinemia has been established as a risk factor for cardiovascular disease. The objective was to investigate total plasma homocysteine concentrations in children. and adolescents with type 1 diabetes and a control group. Method: Twenty-seven children with type 1 diabetes and 27 subjects of an age- and sex-matched control group were recruited. Fasting samples were collected for plasma total homocysteine, serum vitamin B-12, folate, and creatinine. Results: Fasting total homocysteine concentrations showed no difference between patients and controls (5.6 +/- 2.9 mu mol/L vs 5.7 +/- 2.2 mu mol/L; p > 0.05). The diabetic patients had significantly higher serum folate than the healthy controls (11.4 +/- 3.3 ng/mL vs 9.4 +/- 4.1 ng/mL; P = 0.02 and higher serum B-12 than the control group (282.8 +/- 119 pg/mL vs 228.5 +/- 50.9 pg/mL; P = 0.03). Total plasma homocysteine concentration correlated with age (r = 0.44, P = 0.02), weight (r = 0.56, P = 0.002), body mass index (r = 0.57, P = 0.002), folate (r = -0.48, P = 0.01), and creatinine (r = 0.41, P = 0.03) in diabetic patients. In stepwise multivariate regression model for diabetics, the independent correlates for total plasma homocysteine concentration was folate (P = 0.002). Conclusion: We concluded that fasting plasma total homocysteine concentrations were within normal limits in children and adolescents with type 1 diabetes who were without any clinical evidence of microvascular and macrovascular complications.Öğe The role of cord blood IGF-I levels in preterm osteopenia(FREUND PUBLISHING HOUSE LTD, 2006) Atabek, ME; Pirgon, O; Yorulmaz, A; Kurtoglu, SObjective: Osteopenia is a frequent condition in preterm infants. This prospective study was designed to assess the relationship between cord blood insulin-like growth factor-I (IGF-I) levels and bone mineralization in healthy premature infants. Methods: Twenty preterm infants (ten males and ten females) were studied. We determined the bone mineral density (BMD) and bone mineral content (BMC) of healthy premature infants by dual-energy X-ray absorptiometry and also studied the correlation between IGF-I and other parameters and the influence of cord blood IGF-I concentrations on bone mineralization in these infants. Results: The mean concentration of IGF-I was 13.6 +/- 16.9 ng/ml and BMD and BMC were 0.249 +/- 0.06 g/cm(2) and 3.09 +/- 1.18 g, respectively. Cord serum levels of IGF-I had significantly positive correlations with BMD (r = 0.605, p = 0.008), but not BMC (r = 0.242, p = 0.367). In stepwise regression analysis, IGF-I emerged as a significant predictor of BMD (beta = 0.595, p 0.015) contributing to 35.4% of its variability. Conclusion: We found a relationship between cord blood IGF-I and BMD in preterm neonates, suggesting that even within an unremarkable population, IGF-I might be important to ensuring bone health.Öğe Serum magnesium concentrations in type 1 diabetic patients: Relation to early atherosclerosis(ELSEVIER IRELAND LTD, 2006) Atabek, ME; Kurtoglu, S; Pirgon, O; Baykara, MHypomagnesemia and sub-clinical atherosclerosis are common in type 1 diabetic patients, and are especially common in poorly controlled and chronically treated diabetics. The aim of this study was to evaluate the relationships between serum magnesium (Mg) and intima-media thickness (IMT), and functions, of common carotid artery (CCA), accepted as markers of early carotid atherosclerosis in type I diabetic patients. Serum magnesium levels were measured in 51 diabetic patients (26 girls and 25 boys). Age, duration of diabetes as well as major cardiovascular risk factors, including anthropometric and metabolic parameters were matched between girls and boys. CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance (CSC), cross-sectional distensibility (CSD), diastolic wall stress (DWS), and incremental elastic modulus (IEM). The difference for serum Mg was significant between diabetic girls and boys (0.75 +/- 0.09 mmol/l versus 0.86 +/- 0.14 mmol/l; p = 0.02). Mg levels were correlated with IMT (r = -0.58, p = 0.004) and DWS (r = -0.49, p = 0.01) in girls and with IMT (r = -0.55, p = 0.007) and DWS (r = -0.46, p = 0.03) in boys. In a multivariate regression model, Mg, systolic blood pressure and waist-hip ratio emerged as independent correlates for mean IMT in girls with the total variance explained being 63%, and Mg and triglycerides emerged as independent correlates for mean IMT in boys with the total variance explained being 68%. Mg did not emerge as independent correlates for mean DWS in both girls and boys. Serum magnesium levels in children and adolescent patients with type I diabetes are associated with early atherosclerosis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.Öğe Tetanus in a fully immunized child(ELSEVIER SCIENCE INC, 2005) Atabek, ME; Pirgon, O[Abstract not Available]Öğe Zimmermann-Laband syndrome in an infant with an atypical histologic finding(SPRINGER, 2005) Atabek, ME; Pirgon, O; Sert, A; Toy, HZimmermann-Laband syndrome is an inherited disorder that is characterized by abnormalities of the head, face, hands, and feet. Most children with this disorder have generalized hypertrichosis, large gingivae, and hypoplasia of the fingernails and toenails. We report a male infant who exhibited typical features of Zimmermann-Laband syndrome with an unusual histopathologic finding. Excised tissue from the infant's gingivae showed papillary projections that were composed of hyperplastic stratified squamous epithelium with different amounts of keratinization.
