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  • Küçük Resim
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    Biological, phytochemical, and physico-chemical properties of two commercial Nigella sativa seed oils: A comparative analysis
    (ISTANBUL UNIV, FAC PHARMACY, 2018) Aumeeruddy, Muhammad Zakariyyah; Aumeeruddy-Elalfi, Zaahira; Neetoo, Hudaa; Zengin, Gökhan; Fibrich, Bianca; Rademan, Sunelle; van Staden, Analike Blom
    This study was designed to evaluate and correlate the biological, phytochemical, and physicochemical properties of two NSS (Nigella sativa seed) oils (N1 and N2). The biological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity. Physicochemical properties including colour, total soluble solids (TSS), and density were also investigated. N2 exhibited higher antibacterial, NO scavenging, extracellular antimelanogenic, and anticancer activity against the HeLa cell line compared to N1, which showed higher antityrosinase activity. TPC (total phenolic content) and TFC (total flavonoid content) of N1 were significantly higher than N2 while TTC (total tannin content) was higher in N2. In fact, TTC was strongly correlated (R=1.000) with the antioxidant, extracellular antimelanogenic, and HeLa cell inhibitory activity. To conclude, NSS oil may be considered as a complementary and alternative therapy in the management of infectious and chronic diseases but warrants further in vivo pharmacological validation and toxicological analysis.
  • Küçük Resim
    Öğe
    Pharmacological Activities, Chemical Profile, and Physicochemical Properties of Raw and Commercial Honey
    (ELSEVIER, 2019) Aumeeruddy, M. Z.; Elalfi, Zaahira Aumeeruddy; Neetoo, H.; Zengin, Gökhan; van Staden, Analike Blom; Fibrich, Bianca; Lambrechts, Isa A.; Rademan, Sunelle; Szuman, Karina M.; Lall, Namrita; Mahomoodally, Mohamad Fawzi
    This study was designed to evaluate and correlate the pharmacological, phytochemical, and physicochemical properties of raw unifloral Mauritian eucalyptus honey (EH) and a commercially available honey (CH). The pharmacological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity (MCF-7 and HeLa cell toxicity). The presence of phytochemicals including alkaloids, flavonoids, saponins, phenols, anthraquinones, and steroids were determined along with the total phenolic (TPC), total flavonoid (TFC), and tannin content (TC). Physicochemical properties including the pH, colour, total soluble solids, and density were also investigated. The results showed that EH displayed greater antibacterial, antioxidant, and anticancer activity against the MCF-7 cell line compared to CH, which also showed higher extracellular antimelanogenic activity. MH (IC50 = 532.75 mu g/ml) displayed significantly greater scavenging activity than CH (IC50 = 647.6 mu g/ml). To conclude, honey may be potentially exploited as complementary and alternative therapies for the management of infectious and chronic diseases.