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    Calcified intracranial hydatid cyst: case report
    (2011) Köktekir E.; Erdem Y.; Gökçek C.; Karatay M.; Yilmaz A.; Bayar M.A.; Sümer S.
    We present a 26-year-old patient who did farming related work had an asymptomatic intracranial hydatid cyst. A calcified intracranial cystic mass was found on radiological investigations and the patient underwent surgery. The mass was totally excised. The histopathology result reported a hydatid cyst. There were no postoperative complications. Calcification is quite rare in cerebral hydatid cyst. The computed tomography and magnetic resonance imaging provide information that is especially useful for preoperative diagnosis. Observing membrane detachment and daughter cysts during these investigations is pathognomonic. The presence of calcification in the cyst wall and intracystic membranes indicated hydatid cyst.
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    A case of Sjogren's syndrome accompanied by signs of non-cardiac pulmonary edema and infection [Non-kardiyak akci?er ödemi ve enfeksiyon bulgularinin eşlik etti?i Sjögren sendromu olgusu]
    (2013) Sümer S.; Efe P.B.; Ural O.; Yilmaz S.
    At first presentation connective tissue diseases may mimic infectious diseases. But recurrent non-cadiac pulmonary edema accompanied by serious infectious signs is observed rarely. This patient presented with signs of pneumonia, and developed recurrent non-cadiac pulmonary edema, and had to be intubated despite appropriate treatment and Sjögren's syndrome was diagnosed after examinations and detailed history which were warranted by lack of treatment response. She was treated with hydroxychloroquine. This patient's problem was thought to be due to both findings of systemic involvement of connective tissue disease and increased frequency of infectious diseases in these patients.
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    Evaluation of one year response of treatment naive chronic hepatitis B patients to 245 mg/day tenofovir disoproxil fumarate [Naif kronik hepatit B hastalarinin bir yillik 245 mg/gün tenofovir disoproksil fumarate tedavi sonuçlarinin de?erlendirilmesi]
    (2013) Demir N.A.; Kölgelier S.; Demir L.S.; Sümer S.; Dikici N.; Özçimen S.; Inkaya A.C.
    Objective: In this study treatment response of 201 chronic hepatitis B (CHB) patients to 245 mg/day tenofovir disoproxil fumarate (TDF) was evaluated upon 48th week of treatment. Material and Method: This retrospective study included 201 treatment naive chronic hepatitis B patients who admitted to infectious diseases clinics of Adiyaman State Hospital, Adiyaman 82nd Year State Hospital and Selçuk University Selçuklu Medical Faculty between 01-Jan-2010 and 31-Dec-2011. Indication for biopsy was defined using American Association for the Study of Liver Disease (AASLD) criteria. Patient charts were retrospectively reviewed. Data were entered to SPSS 16.0 package program. Regarding statistical evaluation chi square test was used for cathegorical variables, and T test, Mann Whitney U test was used for continous variables. For analysis of repeated measurements variance analysis for repeated measures was used and significant groups were tested by signed rank test. p<0.05 was considered statistically significant. Results: One hundred thirty eight (68.7%) patients were males, 63 (31.3%) were females, and mean age was 39.9±12.5. HBeAg was positive in 88 (43.8%) and anti-HBe was positive in 113 (56.2%) patients. Median value for HBV DNA was 52920000 (6032800-34x109) IU/mL, ALT was 98.0 (14.0-665.0) u/L. At 24th week HBV DNA level was below 400 copy/ml in 57% of HBeAg positive and 69.5% of HBeAg negative patients and at 48th week in 81.3% of HBeAg positive and 89% of HBeAg negative patients. At 24th week of treatment ALT level normalized in 64.4% of HBeAg positive and 67.3% of HBeAg negative patients and at 48th week in 83% of HBeAg positive and 79% of HBeAg negative patients. ALT, and HBV DNA values significantly decreased relative to controls. Follow up did not reveal any significant change in creatinine, phosphor, calcium and ALP values. Conclusion: We conclude that TDF treatment was effective and safe during follow up. Because long term treatment is needed for CHB, more long term studies with big sample sizes are needed to determine effectiveness and side effects of tenofovir treatment.
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    The importance of soluble urokinase plasminogen activator receptor in patients with acute brucellosis [Solubl ürokinaz plazminojen aktivatör reseptörü’nün akut brusellozlu hastalardaki önemi]
    (Nobelmedicus, 2014) Demir N.A.; Daği H.T.; Fındık D.; Sümer S.; Ural O.; Kölgelier S.
    Objective: Brucellosis is a common zoonotic infectious disease especially in Mediterranean countries. Inflammatory markers are elevated during the course of acute brucellosis. C-reactive protein (CRP) is the most commonly used biochemical marker in clinical practice. Soluble urokinase type plasminogen activator receptor (suPAR) is an interesting biomarker which has drawn attention recently. Purpose of this study is to examine correlation between suPAR and CRP levels as markers of infectious disease in patients diagnosed with acute brucellosis. Material and Method: This study included 125 acute brucellosis patients and 50 healthy controls. Pretreatment blood samples were taken from the patients. suPAR levels were measured using ELISA and CRP levels were measured with nephelometry. Results: There was a positive correlation between suPAR levels and CRP, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (p=0.045, 0.039, 0.040; respectively). When we compared patient and control groups, CRP and suPAR levels were significantly higher than controls (p=0.001, 0.001; respectively). Growth in blood culture was detected in 14 (11.2%) patients. There was not a significant difference between patients who have or did not have growth in blood cultures (p=0.117). In the ROC curve analysis performed for suPAR, area under the curve (AUC) was 93.6% (p=0.001). Sensitivity and specificity were calculated as 84.8% and 86.0%, respectively, when suPAR’s cut-off value was taken as 3.85 ng/mL according to the ROC curve. Conclusion: Results of this study suggest that suPAR, like CRP, is a promising biomarker in acute brucellosis. © 2015, Nobelmedicus. All Rights Reserved.