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Öğe Clinical importance of lipid profile in neonatal calves with sepsis(HELLENIC VETERINARY MEDICAL SOC, 2018) Aydogdu, U.; Coskun, A.; Yildiz, R.; Guzelbektes, H.; Sen, IIn this study, it was aimed to determine of diagnostic importance of blood lipid levels in neonatal calves with sepsis. The study was carried out on a total of 70 calves, 60 with sepsis and 10 healthy calves. The calves with sepsis were included in the study, according to clinical and hematological findings. The blood samples were taken from the V. jugularis for hematological, lipid profile and biochemical analyzes after the routine clinical examinations of the calves. There were significantly (P < 0.05) decrease in body temperature, increase in respiration rate and capillary refill time in the calves with sepsis compared to control group. The levels of blood urea nitrogen, creatinine concentrations of calves with sepsis were significantly higher (P < 0.05), however, levels of total cholesterol, HDL and LDL concentrations were significantly lower (P < 0.05) than control group. In addition, blood triglyceride and VLDL concentrations of calves with sepsis were higher than control group, however there was no statistical difference. In conclusion, serum total cholesterol, HDL and LDL in neonatal calves with sepsis could be used in evaluation of the sepsis in calves.Öğe Effects of nutritional therapy or N-acetyl-cysteine (NAC) treatment on biochemical markers and liver histology in dogs with CCL4-induced hepatic necrosis(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2005) Sen, I; Turgut, K; Ok, M; Kiran, MM; Guzelbektes, H; Ortatatli, M; Birdane, FMThe purpose of this study is to evaluate the potential beneficial effects of nutritional therapy or N-acetyl Cysteine (NAC) treatment on hepatic necrosis experimentally induced by CCL4 in dogs. Eighteen healthy mixed breed dogs of both sexes were randomly divided into 3 equal groups and received a single oral dose of CCL4 (2.5 ml/kg body weight). Dogs of control group and of experimental group I were fed with maintenance diet (Hills) and with canine prescription k/d diet (Hills) respectively, once a day. Dogs of the experimental goup II were fed with maintenance diet and were treated by NAC (140 mg/kg in the first oral dose followed by 70 mg/kg 6 hours later for 30 days). Serum enzyme (ALT and ALP) activities and bilirubin concentrations (total and direct) were monitored on the 1(st), 5(th), 10(th), 20(th) and 30(th) days. Ultra-sonographies, BSP clearance and liver biopsies for histological evaluation were performed on the 10(th), 20th and 30th days. Marked increases of serum enzyme activities were noticed since the 1(st) day and persisted until the 15th - 20th days in all CCL4-intoxicated dogs. Total and unconjugated bilirubin concentrations also slightly increased in serum of control dogs and dogs of the experimental group I (nutritional therapy) from the 1(st) day to the 15th day, whereas in dogs treated by NAC, significant fluctuations have persisted until the 30(th) day. BSP retention rates were markedly extended from the 1(st) to the 20(th) days in all groups, but the BSP clearance was significantly more depressed in control dogs and in dogs treated by NAC than in those received nutritional therapy (p < 0.05). Morphological changes (hyperechogenicity of the liver parenchyma) and tissue lesions (hydropic degeneration and hepatic necrosis) were evidenced in all dogs. Nevertheless, degenerative changes were less severe (only grades 1 and 2, particularly on the 20(th) and 30(th) days) and were associated with an increase of hepatocyte regeneration in experimental group II. These results showed that the intensity of liver injure could be assessed through BSP retention test and histological analysis and that nutritional therapy, not NAC treatment. partially attenuated CCI4 - hepatotoxicity in dog.Öğe The evaluation of coagulation profiles in calves with suspected septic shock(SPRINGER, 2006) Irmak, K; Sen, I; Col, R; Birdane, FM; Guzelbektes, H; Civelek, T; Yilmaz, AThe purpose of the study reported here was to evaluate the haemostatic function in calves with suspected septic shock and to reflect the occurrence of disseminated intravascular coagulation (DIC). Twenty-six calves suspected of having septic shock (experimental group) and 10 clinically healthy calves (control group) were used. On admission, the experimental group of calves had been ill for an average of 2 days. Therapy was applied to the experimental group of calves. The packed cell volume (PCV), haemoglobin (Hb), white blood cell (WBC), red blood cell (RBC) and platelet (PLT) counts were determined. Blood smears for toxic neutrophil and schistocyte intensity were evaluated. For the coagulation profile, plasma activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen and fibrin/fibrinogen degradation products (FDPs) values were determined. Toxic neutrophils in blood smears were observed in 12 calves of the experimental group. APTT was prolonged in the experimental group compared with the control group (p < 0.05). Fibrinogen concentration was found to be higher in the experimental group than in the control group (p < 0.001). Total leukocyte counts were higher in the experimental group compared with the control group (p < 0.01). Platelet counts in the experimental group were lower than the control group (p < 0.001). However, when the individual values of coagulation profiles of each calf were evaluated, 8 calves had at least three abnormal coagulation profiles (APTT > 72 s, PT > 34.5 s, TT > 33.7 s, FDPs > 5 mu g/ml, PLT <= 150 x 10(3)/mm(3)) and abnormal erythrocyte morphology (schistocytes >= 1). The most common abnormal tests in the coagulation profile were APTT and PT (7 cases), FDPs (6 cases), thrombocytopenia (4 cases), and schistocytes in blood smears (8 cases) in these 8 calves. The results of this study indicate that DIC might be a significant risk factor for mortality in calves with suspected septic shock.Öğe The Role of Ultrasonography in the Diagnosis of Bacterial Prostatitis in Dogs(INDIAN VETERINARY JOURNAL, 2000) Maden, M; Birdane, F. M; Sen, I; Hadimli, H HThis report describes a paraprostatic cyst in a sexually intact 7 years old Boxer. The clinical history of the dog revealed dysuria, hematuria, constipation and lameness in the right hind leg. An abdominal mass were discovered on clinical examination of the dog. Transabdominal ultrasonographic examination showed an abdominal mass with a cavernous pattern and a hyperechoic wall. The mass was filled with anechoic fluid and was observed to be related to the prostate and adjacent to the urinary bladder. It was decided to remove the mass surgically, Microscopic evaluation of the cystic mass revealed necrotic debris in the lumen along with fibrin, the cyst wall was rich in fibrous tissue and contained bony structures. The prostatic cyst described in this study was identified as an osseous metaplastic paraprostatic cyst on the basis of the clinical, laboratory, ultrasonographic and microscopic findings.Öğe Sensitivity of the Urine Amylase-creatine Ratio and Amylase-creatinine Clearance Ratio in the Diagnosis of Acute Pancreatitis in Dogs.(INDIAN VETERINARY JOURNAL, 2001) Turgut, Kürşat; Çankaya, H; Sen, I; Kiran, Metin Münir[Abstract not Available]Öğe Serum concentrations of tumor necrosis factor-alpha in neonatal calves with presumed septicemia(AMER COLL VETERINARY INTERNAL MEDICINE, 2004) Basoglu, A; Sen, I; Sevinc, M; Simsek, AThis study was performed to determine the concentrations of tumor necrosis factor (TNF) in the serum of neonatal calves with presumed sepsis and determine the correlation between serum concentrations of TNF and the severity and outcome of disease. Thirty-five sick calves <30 days old that suffered from enteritis, respiratory disease, or both were considered suitable for inclusion in this study by satisfying clinical and laboratory criteria suggestive of septicemia. At admission, blood samples were collected from all calves to determine the prevalence of high concentrations of TNF. The clinical course and outcome of disease then were recorded. Of the 35 calves with presumed sepsis, 10 had high serum TNF concentrations. Scleral injection, weak or absent suckling reflex, sternal or lateral recumbency, unresponsive or comatose state, and death rate of calves with high serum TNF concentration were greater than those values for calves without high serum TNF concentration. Calves with high serum TNF concentration had significantly lower mean IgG (P < .001), globulin (P < .0001), and calcium (P < .0001) concentrations; greater serum creatinine concentrations (P < .0001); and greater than or equal to2+ toxic changes in neutrophils than did calves without high serum TNF concentrations. Mean values for packed cell volume, band neutrophil count, and venous P-CO2 were significantly (P < .007) higher in the group of calves with high serum TNF concentration. Results of this study indicate that serum TNF concentration is correlated with clinical criteria of sepsis in neonatal calves. A close association was apparent between disease severity and serum TNF concentrations in this group of calves with presumed septicemia.Öğe Serum GGT and ALP enzyme activities in calves with failure of passive transfer of antibody(INDIAN VETERINARY JOURNAL, 2003) Sevinc, M; Sen, I; Irmak, K; Turgut, K[Abstract not Available]
