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Öğe Acute-phase response after radioiodine treatment in hyperthyroidism(LIPPINCOTT WILLIAMS & WILKINS, 2007) Sari, Oktay; Tunc, Recep; Kisakol, Gurcan; Dostbil, Zeki; Serdengecti, MustafaPurpose: Acute-phase response is an innate body defense seen during acute illnesses and involving the increased production of certain blood proteins termed acute-phase proteins. There are limited data about acute-phase response after radioiodine therapy. This study is designed to determine whether acute-phase response changes after radioiodine therapy. Materials and Methods: Twenty-six hyperthyroid patients were included in this study, aged between 25 and 69 years (mean, 47.7 +/- 10.5, 18 females and 8 males). All patients were given radioiodine therapy (8-15 mCi). Leukocyte, hemoglobin, platelet, erythrocyte sedimentation rate, and C-reactive protein (CRP) were measured before radioiodine therapy and after 24 hours, 72 hours, 1 week, 1 month, and 3 months. Free T3, free T4, TSH, thyroglobulin (Tg), antithyroid antibody, and antimicrosomal antibody (AMA) were measured before radioiodine therapy and after 1 and 3 months. Results: Mean CRP levels were 3.74, 3.90, 4.29, 5.71, 3.85, and 5.41 mg/L, respectively. There was a significant difference between the initial and the first-week results. Mean Tg levels were 68.15, 143.90, and 77.00 ng/mL, respectively, with a significant difference between the initial and the first-month and third-month results. Mean AMA levels were 158.80, 178.85, and 636.25 IU/mL, respectively, demonstrating a significant difference between the initial and the third-month and first- and third-month results. Conclusion: We have shown that radioiodine therapy causes an increase in CRP, Tg, and AMA levels. We conclude that radioiodine treatment is a cause of the increase in the CRP, Tg, and AMA levels in hyperthyroid patients.Öğe Comparison of Ventilation-Perfusion Scintigraphy With MR Angiography in Patients With Swyer-James Syndrome(LIPPINCOTT WILLIAMS & WILKINS, 2013) Serdengecti, Mustafa; Sakarya, Mehmet E.; Ilerisoy, Zeynep Y.; Odev, KemalPurpose: The aim of this study was to establish the value of magnetic resonance angiography (MRA) in diagnosing) Swyer-James syndrome (SJS) and to compare MRA and ventilation-perfusion (V/Q) scan results in patients with established SJS. Methods: The V/Q scans and the MRA findings of 22 lungs of 11 patients with SJS (6 males, 5 females; age range: 17-69 years, mean: 38.4 years) were retrospectively studied. The perfusion scan was performed after the injection of Tc-99m macroaggregated albumin. After 2 days, the ventilation scan was performed by using Tc-99m diethylene triamine penta-acetic acid aerosol. The MRA was performed with a 1.5 T magnetic resonance unit. We compared the MRA and V/Q scan findings of the lungs of the patients. Results: The V/Q scans showed the characteristic pattern of a matched V/Q defect on the affected lungs. The MRA displayed a smaller pulmonary artery and markedly poor peripheral vasculature on the affected side in all patients. The MRA had a sensitivity of 84.6%, a specificity of 100% for the detection SJS. Interobserver variability was minimum as indicated by a weighted kappa statistic of 0.818. Conclusion: This study indicates that the MRA is a fast, accurate, without radiation, and noninvasive technique for supporting the diagnosis of SJS. But, V/Q scans showed additional segmental perfusion/ventilation abnormalities on contralateral lung to reveal the segmental involvement of SJS. As a result, the MRA has no more any extra advantages for patient management.Öğe The outcome of I-131 therapy with fixed doses for Graves disease and toxic nodular/multinodular goiter in endemic region(SOC NUCLEAR MEDICINE INC, 2011) Serdengecti, Mustafa; Sari, Oktay[Abstract not Available]Öğe Thyroid Hemiagenesis and Graves' Disease in a Child(LIPPINCOTT WILLIAMS & WILKINS, 2009) Serdengecti, Mustafa; Ayan, Asli; Sari, OktayHemiagenesis of the thyroid is a rare malformation and Graves' disease with ophthalmopathy is reported quite rarely in adult patients but is not seen in children, This is a report of an 8-year-old girl with congenital absence of the left thyroid lobe, or hemiagenesis.
