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    Serum apolipoprotein B100 concentrations in dairy cows with left sided displaced abomasum
    (ECOLE NATIONALE VETERINAIRE TOULOUSE, 2006) Civelek, T.; Sevinc, M.; Boydak, M.; Basoglu, A.
    The purpose of this study was to examine the alteration in serum apolipoprotein B100 (apo B100) concentrations and to evaluate the liver steatosis in dairy cows with left sided displaced abomasum (LSDA). A total of 33 Holstein cows (9 clinically healthy and 24 with LSDA) were used. Serum concentrations of apo B100 were assayed by single radial immunodiffusion method. Serum total bilirubin, glucose, cholesterol, triglyceride, total protein, albumin and high density lipoprotein (HDL) concentrations and aspartate amino transferase (AST) and gamma glutamyl transferase (GGT) activities were measured colorimetric methods. Biopsy samples were obtained from liver under local anesthesia with percutaneous biopsy needle for histopathological examination. Serum apo B100 concentrations were significantly decreased in cows with LSDA (p < 0.001) and were associated to abnormal lipid biochemistry (marked decreases of triglyceride, cholesterol and lipoprotein concentrations, p < 0.001), and to cholestasis (significant inceases of total bilirubin concentrations (p < 0.001) and of serum GGT activities (p < 0.01)) leading to liver injury (marked increases of AST activities (p < 0.001), and decreases of total protein (p < 0.01) and albumin (p < 0.05) concentrations). Liver biopsies revealed a severe fat infiltration (41.5 +/- 2.5%) in cows with LSDA, and the degree of hepatic lipidosis was negatively correlated to apo B 100 concentrations (r = -0.591). These results suggest that the apo 13100 would be a marker for hepatic steatosis and would provide a non invasive alternative to liver biopsy for FL (fatty liver) diagnosis.