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Öğe Haptoglobin and SAA Concentrations and Enzyme Activities in Bronchoalveolar Lavage Fluids From Calves With Bronchopneumonia(Ecole Nationale Veterinaire Toulouse, 2012) Coskun, A.; Guzelbektes, H.; Simsek, A.; Aydogdu, U.; Sayin, Z.; Sen, I.The aim of this study was to evidence acute phase response in bronchoalveolar lavage fluids (BALF) from calves with bronchopneumonia by measuring Haptoglobin and Serum Amyloid A (SAA) concentrations and some enzyme activities. For that, 30 calves with bronchopneumonia and 8 clinically healthy calves were selected on the basis of the clinical signs and examination and laboratory analysis. Haematological analysis (White Blood Cell counts) was performed using an automated haematology cell counter. In blood and BALF samples, gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) activities and the total protein concentrations were measured using an automatic analyzer, whereas Haptoglobin and SAA concentrations were measured with commercially available ELISA kits. Proteinemia, GGT activity, haptoglobin and SAA concentrations in sera from diseased calves were significantly and dramatically increased compared to the healthy controls, while increases in other parameters (leukocyte count, ALP and LDH activities) were not statistically significant. Significant increases in LDH and GGT activities and in concentrations of the 2 acute phase proteins were also evidenced in BALF samples from calves with bronchopneumonia compared to the controls. In addition, except in 2 diseased animals, haptoglobin and SAA concentrations in BALF samples were above 250 and 25 mu g/L, respectively, whereas they have remained below the threshold values in all clinically healthy calves. These results show that BALF haptoglobin and SAA concentrations are useful acute phase proteins (APPs) for the determination of pulmonary inflammation in calves and future studies are needed to determine the importance of local acute phase response in the respiratory system.Öğe An investigation of equine infectious anaemia infection in the Central Anatolia region of Turkey(SOUTH AFRICAN VET ASSOC, 2007) Yapkic, O.; Yavru, S.; Kale, M.; Bulut, O.; Simsek, A.; Sahna, K. C.In this study, 162 horses, 80 donkeys and 51 mule serum samples were collected in Konya city. Additionally, 64 horse serum samples from Ankara and 49 samples from Kayseri city were included in the study. A total of 406 serum samples were examined by agar gel immunodiffusion (AGID) and enzyme-linked immunosorbent assay (ELISA) for antibody to equine infectious anaemia virus (EIAV) and no positive result was detected.Öğe Serological and virological investigation of bovine viral diarrhea virus (BVDV) infection in cattle with abortion problem(WILEY-BLACKWELL, 2012) Bulut, O.; Avci, O.; Yapici, O.; Yavru, S.; Simsek, A.[Abstract not Available]Öğe Use of aluminium hydroxide and calcium phosphate as delivery molecules for TGF-beta(1)(INDIAN VETERINARY JOURNAL, 2007) Ucan, U. S.; Yildirim, S.; Simsek, A.; Ortatatli, M.; Erganis, O.Transforming Growth Factor-beta(1) (TGF - beta(1))'s mitogenic activities have been documented to some extent in dentinogenesis and wound healing. However, TGF as a therapeutical agent has not been considered neither in veterinary nor in medical dentistry so far. In order to examine this, it is first necessary. to incorporate the cytokine to a slow delivery system and then to show its various effects on different types of cells. The present study was designed to evaluate the properties of two different adjuvants, aluminium hydroxide (AH) and calcium phosphate (CP), as delivery substances for recombinate human TGF-beta(1).
