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    PLASMA DISPOSITION OF CEFOPERAZONE AFTER SINGLE INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATIONS IN CAMELS (CAMELUS DROMEDARIUS)
    (AKADEMIAI KIADO ZRT, 2018) Aboubakr, Mohamed; Soliman, Ahmed; Uney, Kamil; Elmas, Muammer
    The plasma disposition of cefoperazone was investigated after intravenous (IV) and intramuscular (IM) administrations of 20 mg/kg as a single dose in six camels (Camelus dromedarius) in a crossover design. Blood plasma samples were analysed by high-performance liquid chromatography (HPLC). After IV administration, elimination half-life (t(1/2 beta)), volume of distribution at steady state (V-dss), total body clearance (Cl-tot) and mean residence time (MRT) of cefoperazone were 1.95 h, 0.38 L/kg, 0.17 L/h/kg and 2.16 h, respectively. After IM administration of cefoperazone, peak plasma concentration (C-max) was 21.95 mu g/mL and it was obtained at (t(max)) 1.23 h. Absorption half-life (t(1/2ab)), elimination half-life and mean absorption time were 0.45 h, 2.84 h and 2.07 h, respectively. The bioavailability of cefoperazone was 89.42%. The lack of local reaction or any other adverse effects and the very good bioavailability following IM administration indicate that cefoperazone might be a promising alternative treatment for a variety of infectious diseases in camels.