Yazar "Türkmen K." seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association of fetuin - A levels with carotid intima media thickness and valvular calcification in hemodialysis and peritoneal dialysis patients(2013) Solak Y.; Inal A.; Atalay H.; Kayrak M.; Biyik Z.; Türkmen K.; Yeksan M.Background: Fetuin-A is a negative acute-phase reactant which prevents vascular calcification. Coronary artery disease (CAD) is the most important cause of mortality in patients undergoing renal replacement therapy (RRT). The key element of cardiovascular disease (CVD) seen in end-stage renal disease patients who are on dialysis treatment is accelerated calcific atherosclerosis. There are a limited number of studies in which HD and PD is compared in terms of fetuin-A level. OBJECTIVE: We aimed to investigate the association of serum fetuin-A level with valvular calcification and predictors of CAD in hemodialysis (HD) and peritoneal dialysis (PD) patients. MATERIAL and METHODS: 39 HD (24 males, 15 females) and 39 PD (25 males, 14 females) patients were included in the study. We determined carotid artery intima media thickness (CIMT) and evaluated heart valve calcification via echocardiography. We also measured serum fetuin-A level, CRP, ferritin, fibrinogen and serum albumin level. According to fetuin-A level, patients were stratified into quartiles. RESULTS: Fetuin-A level was significantly lower in HD patients when compared with that of PD patients (28.6±5.934 ng/ml, 32±4.8 ng/ml respectively p<0.001). There was a significant negative correlation between CIMT and fetuin-A level. CIMT was found to be lower in PD patients than in HD patients. We found a positive correlation between fetuin-A and dialysis adequacy and albumin level. There was a negative correlation of fetuin-A with age, fibrinogen, ferritin and CRP. Fetuin-A level was lower in patients with aortic calcification. Conclusion: Fetuin-A level was found to be lower in HD patients. Fetuin-A may be a novel marker for CVD in patients undergoing RRT.Öğe The comparison of four different dialysates on QT dispersion and arrhythmias in hemodialysis patients(2012) Türkmen K.; Mil S.; Solak Y.; Türk S.OBJECTIVES: Sudden cardiac death (SCD) is common in patients with end-stage renal disease receiving hemodialysis. SCD may be caused by electrolyte imbalance or malignant arrhythmias in hemodialysis patients. We aimed to evaluate the effects of four different dialysates on QT dispersion and arrhythmia. MATERIAL and METHODS: Twenty-one patients receiving hemodialysis were enrolled. Four different dialysates were used and twelve-lead ECG measurements were recorded to determine QTc and QTc dispersion. Holter ECG was performed to assess arrhythmia. RESULTS: In group 1 (1.0 K +, 1.5 Ca++), predialytic and postdialytic QTc dispersion measurements were 52.3±11.7 and 59.2± 13.1 msec respectively and this is statistically significant (p=0.007). In group 2 (2.0 K +, 1.5 Ca++), group 3 (1.0K +, 1.75Ca++), and in group 4 (2.0 K +, 1.75Ca++), QTc dispersion measurements were 53.5±14.4 and 53.2± 15.0 msec, 53.5±14.4 and 53.2±15.0 msec, 50.8±12.0 and 52.2±13.3 msec, 51.3±12.2 and 52.1±12.3 msec, respectively, and these were not statistically significant. CONCLUSION: In group 1, patients had higher QTc dispersion. There was no statistically significant difference regarding QTc dispersion among the four groups. We also could not find an increased rate of arrhythmias in the groups. These results suggest that there may be other causative risk factors that can affect QT dispersion and arrhythmias in hemodialysis patients.Öğe Relationship between fetuin-A, inflammation, coronary artery calcification in hemodialysis and peritoneal dialysis patients(2012) Türkmen K.; Kayikçio?lu H.; Özbek O.; Gaipov A.; Yerlikaya F.H.; Toker A.; Tonbul H.Z.OBJECTIVE: Vascular calcification is commonly seen in patients with end-stage renal disease (ESRD). Fetuin-A has been found to be a vascular calcification inhibitor and its level is significantly low in ESRD patients. The aim of our study was to investigate the relation between coronary artery calcification, inflammation and fetuin-A levels in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL and METHODS: 46 PD (M/F=28/18) and 34 (M/F=20/14) HD patients were included in the study. Coronary artery calcification scoring was made by multi slice computed tomography. PD and HD patients were divided into 2 groups according to their median CACS values Serum levels of fetuin-A, CRP, IL-6 and TNF-a are studied. RESULTS: There were no differences in demographic features of PD and HD patients. There was a correlation between CACS, advanced age, dialysis vintage and fetuin-A. We could not find any correlation between infiammatory markers and CACS. There was a statistically significant difference between fetuin-A and CACS groups. CONCLUSION: Age, duration of dialysis, fetuin-A levels were found to be related to CACS in PD and HD patients. Fetuin-A may play a role in increased mortality in this population via facilitating CACS.Öğe A retrospective analysis of five year data of end-stage renal disease patients: A single center experience(2011) Türkmen K.; Tunç A.; Solak Y.; Türk S.OBJECTIVES: CKD is a worldwide threat to public health. Approximately 1.8 million people are currently being treated with renal replacement therapy including hemodialysis, peritoneal dialysis and transplantation. The etiology and factors affecting the progression of chronic kidney disease to endstage renal disease (ESRD) differ in industrialized and underdeveloped countries. STUDY DESIGN: The aim of the study was to investigate the etiologies of ESRD, factors affecting progression to ESRD and mortality rates of patients between 2000-2004, in Konya, a city in the Middle Anatolian region of Turkey. MATERIAL and METHODS: We included 417 end-stage renal disease patients (207 female and 210 male) between 16-90 years old receiving RRT for the first time in the study. CKD was diagnosed by GFR measurement that was calculated by MDRD formula. Co-morbidity was expressed using Wright-Khan index. RESULTS: We showed that there was an increased rate of diabetic nephropathy between 2003 and 2004. The increased rate of diabetic nephropathy was found to be statistically significant in the last two years (p<0.005). There was also significant negative correlation between mortality and diastolic BP (r: -0.143, p: 0.05) and the education level of the patients (r: -0.159, p: 0.0002). There was a positive correlation between mortality and serum urea levels (r: 0.193, p: 0.0001), HD through a catheter for the first time (r: 0.140, p: 0.0006), and receiving HD by a continuous RRT modality (r: 0.163, p: 0.0001). CONCLISION: Our study showed that advanced age, increased mean arterial BP before the first RRT, having CVD or DM as an etiology of ESRD, increased erythrocyte sedimentation rate (ESR), decreased serum albumin levels and the presence of co-morbid diseases were the main factors that affected survival of the patients.Öğe Utility of double filtration plasmapheresis in acute antibody mediated renal allograft rejection: Report of three cases(2011) Solak Y.; Atalay H.; Polat I.; Anil M.; Türkmen K.; Biyik Z.; Yeksan M.Plasmapheresis is an extracorporeal procedure, which is often employed to rapidly lower circulating titers of autoantibodies, immune complexes or toxins. There are two types of plasmapheresis namely, regular plasmapheresis (RPP) by centrifugation and membrane filtration, and double filtration plasmapheresis (DFPP) which is a special form of membrane filtration in which two membranes called as plasma separator and plasma fractionator are employed to filter macromolecules more selectively. DFPP have several advantages over RP. Despite widespread utilization of DFPP in the setting of ABO blood group incompatible kidney transplantation, there is no report regarding DFPP in patients with antibody mediated acute renal allograft rejection who are good candidates for beneficial effects of DFPP. Here we report three renal transplant recipients in whom DFPP was applied as a component of anti-rejection treatment regimen.
