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  • Küçük Resim
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    Experimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesis
    (W B Saunders Co-elsevier Inc, 2006) Pampu, A. Alper; Dolanmaz, Doğan; Tüz, Hakan H.; Karabacakoğlu, Aydın
    Purpose: The aim of this study was to evaluate the effects of systemically administered zoledronic acid (ZA) on the bone mineral density (BMD) and bone mineral content (BMC) at mandibular distraction sites in rabbits. Materials and Methods: Eighteen New Zealand white rabbits were randomly divided into 2 groups. Bone lengthening was performed in the left portion of the mandible through distraction osteogenesis at a rate of 0.5 mm every 12 hours for 5 days. While the experimental group rabbits were administered intravenous 0.1 mg/kg ZA, control group rabbits were given only saline infusion during operation. All animals were sacrificed at the end of the consolidation period of 28 days. The mandibles of all animals were removed and both the anterior and posterior pin regions of the regenerate and regenerate region were evaluated by dual energy x-ray absorptiometry (DEXA). BMD and BMC data were statistically analyzed. Results: Except for 1 rabbit from the experimental group that had an infection at the external pin region, all animals showed complete clinical healing. When the values in the group receiving ZA were compared with those of the control group, it was observed that the BMD values of the anterior pin region of regenerate, regenerate region, and posterior pin region increased by 23%, 20%, and 31%, respectively; and BMC values increased by 22%, 24%, and 32%, respectively. When data of these regions were compared, both BMD and BMC were found statistically different in all regions (P <.05). Conclusion: Results of this study showed that ZA had positive effects on new bone formation at and around the distraction gaps of the lengthened rabbit mandibles by distraction osteogenesis.
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    Reconstruction of Temporomandibular Joint Using Distraction Osteogenesis: A Case Report
    (2001) Kişnişci, Reha Ş.; Dolanmaz, Doğan; Tüz, Hakan H.
    Temporomandibular joint (TMJ) ankylosis is one of the major complications following trauma and local or systemic infections and is rarely associated with systemic diseases such as ankylosing spondylitis and rheumatoid arthritis (1.2). The reconstruction of mandibular deformities in a patient with long-term TMJ ankylosis is challenging. The multiple requirements include reconstruction of the TMJ, reconstruction of mandibular asymmetry and soft tissue facial augmentation. Distraction osteogenesis (DO) has become a popular method for the management of the congenital and acquired mandibular deformities. After McCarthy introduced the first clinical application in a human mandible in 1992, many successful results have been reported with distraction osteogenesis for mandibular lengthening and widening and alveolar ridge augmentation (3-6). In recent years, papers involving TMJ reconstruction with distraction osteogenesis have been published (7.8). In this article, a patient with long-term TMJ ankylosis treated with distraction osteogenesis is described.