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    Effects of Prednisolone, l-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas
    (LIPPINCOTT WILLIAMS & WILKINS, 2016) Kose, Dogan; Tarakci, Nuriye; Celik, Zeliha Esin; Vatansev, Husamettin; Cimbek, Emine Ayca; Ugras, Serdar; Sen, Yasar
    The aim of this study is to determine the effects of l-asparaginase (l-ASP), corticosteroids (CSs), and antilipidemics, separately and in combination, on the lipid profiles and the liver and pancreas histology in mice. This study included 8 groups of 7 mice each. Before any drug administration, serum samples were taken from all of the mice. Then, normal saline was applied to the control group, and a medication or combination of medications was applied to the other groups. Levels of triglycerides, cholesterol (COL), and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined, and the livers and pancreases were evaluated histologically at the end of the study. Triglycerides increased significantly in the CS-only and the l-ASP-only groups, COL increased significantly in the CS-only group, and HDL increased significantly in the CS-only and the antilipidemic-only groups. LDL was significantly lower in the CS-only and the l-ASP-only groups. CSs and l-ASP were significantly effective in liver necrosis, l-ASP was significantly effective in liver balloon degeneration, and CS were significantly effective in pancreas vacuolization. Triglyceride measurement is recommended before/during CS and/or l-ASP treatment. Starting with an antilipidemic agent can be considered to avoid possible complications in patients with significantly high rates. Indicators of a possible liver or pancreas injury should also be considered.
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    Neonatal septicemia in tertiary hospitals in Konya, Turkey
    (DERMAN MEDICAL PUBL, 2018) Tarakci, Nuriye; Konak, Murat
    Aim: Neonatal sepsis is one of the leading causes of mortality and morbidity in the developing world. The present study aims to determine the incidence and risk factors of neonatal sepsis in a single center over a four-year period. Material and Method: This is a retrospective study of all cases of culture-proven neonatal sepsis admitted in the neonatal intensive care unit of a single center between January 2013 and December 2016. Clinical features, risk factors, microbiological and biochemical results, and mortality rates were recorded. Associations between risk factors and mortality were investigated. Results: The prevalence rate of neonatal sepsis was 2.7 per 1000 live births (94/30545) and 9.3 per 1000 neonatal admissions (94/10133). Low birth weight (<= 2500g) was recorded in 79 (84%) neonates with sepsis. There was at least one risk factor in all cases. Gram-negative bacteria were more frequently isolated than gram-positive bacteria (63.8% (60/94) vs. 29.7% (28/94)). Klebsiella pneumonia was predominant in both early-onset sepsis and late-onset sepsis (53% (16/30), 29.7% (19/64) respectively). Late-onset sepsis episodes attributed to Klebsiella pneumonia were associated with the highest sepsis-related mortality (41.7%). Discussion: Klebsiella pneumonia was found to be the most common agent in neonatal sepsis and responsible for sepsis-related mortality in this study. Prevalence of neonatal sepsis, its pathogens and risk factors differ in different parts of the world. Region-specific strategies to prevent new infections should be encouraged.