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Öğe Combined usage of testosterone and nandrolone may cause heart damage(ACADEMIC JOURNALS, 2011) Tasgin, Erdal; Lok, Sefa; Demir, NagehanThe aim of this study is to determine the effects of combined application of testosterone and nandrolone on male rabbits during adolescence period for biochemical values which are indicators of damage to heart, liver and kidney. Seven male New Zealand white rabbits, 60-days old, were used in this study. Testosterone (10 mg/kg) + nandrolone deconoate (10 mg/kg) were injected simultaneously to the rabbits in an intramuscular manner once in 1 week for a period of 12 weeks. Blood samples were taken in 0, 4, 8 and 12 weeks. Serum creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl-transferase, creatinine and blood urea nitrogen were measured with an auto-analyzer. Combined use of testosterone and nandrolone caused (p < 0.05) increase in serum creatine kinase-MB activity, but no statistical changes (p > 0.05) were determined in other parameters. As a result, it can be concluded that the use of testosterone plus nandrolone simultaneously during early ages may cause heart damage.Öğe Effect of peanut oil and nandrolone on serum cytokines in pubertal term rats(AGRICULTURAL RESEARCH COMMUNICATION CENTRE, 2018) Tasgin, Erdal; Haliloglu, SeyfullahThe purpose of this study was to determine the effect of nandrolone on cytokine levels in pubertal term female and male rats. Totally 60 pubertal term Spraque Dawley rat (30/30 female/male) were divided into 3 equal groups. Control group received no treatment. PO group received intraperitoneally peanut oil every 5 days with an intervening gap of 2 days where no treatment was given. ND group received intraperitoneally nandrolone decanoate (10 mg/kg) within peanut oil like PO group. At the end of the four weeks, blood samples were obtained. Serum cytokine levels were measured by ELISA. Peanut oil significantly (P<0.05) increased serum levels of interleukin-1 beta and interleukin-6 in pubertal term male rats, while nandrolone decanoate had no any effect on the cytokine levels compared to experimental groups. It may be stated that nandrolone decanoate has no excessive inducer effect on the cytokine synthesis in pubertal male and female term.Öğe Effects of single dose administered nandrolone decanoate on serum cytokine levels and some biochemical parameters in male and female rats.(SCIENTIFIC PUBLISHERS INDIA, 2017) Tasgin, Erdal; Lok, Sefa; Haliloglu, Seyfullah; Demir, Nagehan; Ergin, HaleThe aim this this study was to determine that administration of single higher dose nandrolone decanoate (40 mg/kg) on serum IL-1 beta, TNF-alpha, IL-10 and IL-6 levels and some biochemical parameters during 24 h in male and female rats. The blood samples were taken from 5 male and female rats to obtain their starting values. Then the blood samples were taken from 6 rats in sampling time at 1st, 2nd, 4th, 8th, 12th and 24th h following the nandrolone decanoate administration. There were significant increases determined in the serum IL-1 beta levels, numerical increases in the TNF-alpha levels whereas decreased IL-6 levels were determined. IL-10 levels did not change during experimental period. While serum GGT and BUN levels increased towards the last h of the study, increased ALP levels were observed only female rats. There was no any significance changes were determined in the other biochemical (ALT, AST, CK-MB and LDH) values. As a result, increased IL-1 beta and TNF-alpha levels, proinflammatory cytokines, and some biochemical parameters may be reflect that long term used nandrolone decanoate causes organ damages and effect immune system function. However, effects of long term used nandrolone decanoate on the immune system and organ functions should be detailed evaluated.Öğe Morphometric effects of the combined usage of anabolic androgenic steroids on humerus(SILA SCIENCE, 2012) Lok, Sefa; Tasgin, Erdal; Yalcin, HakanThis study has carried out to examine the effect of the combined usage of anabolic androgenic steroids consumed by athletes on humerus. In this study, twenty-four New Zeland white rabbits were used. Male and female rabbits were separated into two groups. Control group (male n: 6, female n: 6) was fed during 12 weeks without being made any application. 10 mg/kg if testosterone plus 10 mg/kg of nandrolone deaconate were intramuscularly applied on experimental group (male n: 6, female n: 6) one day in a week during 12 weeks. Front extremity bones of materials were revealed by making diseke and were subjected to maceration operation. Upon examining the lengths of humerus bones, growth of the humerus bone has evidently suspended among the subject males that are consumed the drug and the difference has been found significant (p < 0.05). Among males the growth of the length of humerus bones has suspended significantly but among females the same effect has not examined. In conclusion, combined usage of these two steroids may enhance the effects of the testosterone, and thus the relative results are found significant among males comparing to females.
