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  • Küçük Resim Yok
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    The effect of extracoporeal schock waves on intestinal anastomosis
    (2011) Pekin C.; Tekin S.; Kucukkartallar T.; Cakir M.; Tekin A.; Kartal A.
    Background and Objectives: To investigate the effect of extracorporeal shock waves on the healing of intestinal anastomosis. Materials and Methods: Thirty Wistar rats were randomly divided into three groups of ten each comprising of Group I (only laparotomy), Group II (right colon segment resection and end to end anastomosis) and Group III (right colon segment resection and end to end anastomosis). Group III animals a total of 1200 impulse 0.12 mj/mm 2 shock waves on the post-operative 3 rd, 5 th and 7 th days in three session each of which included 400 impulse with 14KV. On the 10 th post operative day, the rats were sacrificed and postmortem examination was done. The explosion pressures were measured using a sphygmomanometer specially designed for this purpose. In the study groups 4 cm intestine segments which include anastomose line was taken out. The segments which include anastomosis of the study group and the control group pieces were histopathologically examined. The fibroblast, collagen, angiogenesis and inflammatory cells were studied. Results: The mean anastomoses explosion pressure for group III was 272±7.895 and the average anastomose explosion pressure was 220±6.831. The difference between the pressure means was significant (P < 0.05). Histological fibroblast/collagen ratio were 14.50±5.66, 274±66.21 and 416±52.44 for Group I, Group II and Group III, respectively. The vein amount was 5.80±3.19, 51.20±10.76 and 75.10±13.80, respectively. In Group III, fibroblast/collagen and vein ratio was significantly higher compared to Group I and II (3.19, 51.20±10.76 and 75.10±13.80, respectively. In Group III, fibroblast/collagen and vein ratio was significantly higher compared to Group I and II (P < 0.05). Conclusion: From the results of our study, extracorporeal shock waves treatment (ESWT) increase the intestinal tensile strength and may be useful to enhance the mechanical strength of anastomosis of the colon during healing.
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    Evaluation of phagocytic function of the spleen after splenic artery ligation in secondary hypersplenism
    (2003) Vatansev C.; Tekin S.; Şahin M.; Serdengeçti M.; Avunduk M.C.
    The aim of this study was to investigate the effects of splenic artery ligation on the phagocytic functions and morphology of the spleen in rabbits in which secondary hypersplenism was induced by splenic vein ligation (SVL). Thirty New Zealand-type rabbits were included in this study. The rabbits were separated into three groups of 10 subjects each. The first group underwent laparotomy, and the second and third groups underwent laparotomy + splenic vein ligation. At the end of the fourth week, the first and second groups underwent laparotomy while the third group underwent laparotomy + splenic artery ligation. At the end of the eighth week, 1 cc of blood was taken from all rabbits to determine hematological parameters. The rabbits were administered with 0.1 mCi/kg of Tc-99m sulfur colloid, and retention rates in the liver and spleen were determined. The spleens of the rabbits were removed and examined histopathologically. Median liver/spleen retention rates were found to be 26.2 count/pixel in the sham group, 29.1 count/pixel in group II and 55 count/pixel in group III. The retention rate in the spleen was significantly lower in group III (p = 0.0001). Leukocyte levels were similar among the groups while erythrocyte and thrombocyte levels were significantly lower in group II than in the other two groups (p = 0,0001). Histopathologically, wide congestion was observed in group II while extended fibrosis and necrosis were observed in the spleens of group III. Although the application of SAL in secondary hypersplenism cases reduces the severity of hypersplenism, it fails to improve the phagocytic function of the spleen.