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Öğe ACUTE ANTERIOR MYOCARDIAL INFARCTION DUE TO CORONARY ARTERY SPASM TRIGGERED BY PSYCHOSOCIAL TRAUMA IN A YOUNG ADULT PATIENT(ELSEVIER IRELAND LTD, 2011) Arıbaş, Alpay; Tekinalp, M.; Akıllı, Hakan; Alihanoğlu, Yusuf İzzettin; Özdemir, Kurtuluş[Abstract not Available]Öğe APICAL BALLOONING SYNDROME (TAKOTSUBO CARDIOMYOPATHY): A CASE REPORT(ELSEVIER IRELAND LTD, 2011) Tekinalp, M.; Akıllı, Hakan; Arıbaş, Alpay; Duman, C.; Alihanoğlu, Yusuf İzzettin[Abstract not Available]Öğe ASSOCIATION OF VENTRICULAR SEPTAL RUPTURE, INFECTIVE ENDOCARDITIS AND INTRACARDIAC THROMBUS FOLLOWING MYOCARDIAL INFARCTION: FIRST CASE REPORT(ELSEVIER IRELAND LTD, 2011) Tekinalp, M.; Dogan, U.; Duman, C.; Soylu, A.[Abstract not Available]Öğe Evaluation of the acute effect of palonosetron on transmural dispersion of myocardial repolarization(VERDUCI PUBLISHER, 2012) Dogan, U.; Yavas, G.; Tekinalp, M.; Yavas, C.; Ata, O. Y.; Ozdemir, K.Background: 5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) and regarded to have a high safety profile. However, several electrocardiographic changes and cardiac arrhythmias have been reported due to administration of 5-HT3 antagonists. Only prolongation of QT interval has been investigated as an index of potential for life-threatening arrhythmias in adult patients using 5-HT3 antagonists. Recently, increase in transmural dispersion of repolarization (TDR) has been proposed as a more reliable determinant of arrhythmogenic potential. Aim: To assess the effects of palonosetron, a second-generation 5-HT3 antagonist, on the T-wave peak to T-wave end (TpTe) interval which has been proposed as a reliable index of spatial TDR. Patients and Methods: A total of 50 consecutive cancer patients (aged: 57 +/- 12 years) who were scheduled to receive emetogenic chemotherapy were included to the study. Baseline12-lead electrocardiography (ECG) recordings were obtained. Then, all patients received 8 mg intravenous dexamethasone followed by a single dose of 0.25 mg intravenous palonosetron administered over 30 seconds. A second ECG was performed 30 minutes after the administration of palonosetron. Indices of cardiac repolarization and TOR before and after the administration of palonosetron were compared. Results: In comparison with baseline there was no statistically significant change in any of the heart rate-corrected parameters, including QT(c) (lead V-5), QT(maxc), QT(minc), QT(cd), TpTe (V-5), TpTe(max), TpTe(min), TpTe(d) and TpTe/QT (V-5). Conclusions: Palonosetron does not have any significant effect on QT(c) and TpTe intervals. It might be the drug of choice for prophylaxis of CINV in cancer patients receiving chemotherapy with known cardiotoxic potential or who have pre-existing cardiac disease that predispose them to drug-induced arrhythmias.Öğe PERICARDIAL EFFUSION IN A PATIENT WITH ULCERATIVE COLITIS: A CASE REPORT(ELSEVIER IRELAND LTD, 2011) Tekinalp, M.; Akıllı, Hakan; Arı, H.; Erdoğan, H. I.; Yazıcı, M.; Güngör, G.[Abstract not Available]Öğe TPE, TPE DISPERSION AND TPE/QT RATIO AS RISK MARKERS OF MALIGN VENTRICULAR ARRHYTMIA IN PATIENTS WITH RHEUMATOID ARTHRITIS(ELSEVIER IRELAND LTD, 2011) Tekinalp, M.; Kayrak, M.; Salli, A.; Bacaksız, A.; Arıbaş, Alpay; Akıllı, Hakan; Küçükşen, S.[Abstract not Available]Öğe AN UNUSUAL ELECTROCARDIOGRAPHIC PRESENTATION OF OCCLUSION OF THE LEFT ANTERIOR DESCENDING ARTERY: INFEROLATERAL ST SEGMENT ELEVATION(ELSEVIER IRELAND LTD, 2011) Dogan, U.; Tekinalp, M.; Can, I.; Aribas, A.[Abstract not Available]Öğe VENTRICULAR SEPTAL RUPTURE COMPLICATION OF ACUTE MYOCARDIAL INFARCTION SECONDARY TO CORONARY ARTERY EMBOLISM IN A PATIENT WITH ATRIAL FIBRILLATION(ELSEVIER IRELAND LTD, 2011) Akıllı, Hakan; Tekinalp, M.; Arıbaş, Alpay; Duman, C.[Abstract not Available]