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Öğe Assessment of Macula and Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Myopia(ORTADOGU AD PRES & PUBL CO, 2012) Ozkagnici, Ahmet; Tokgoz, MineObjective: In the study, analysis of retina structure with optical coherence tomography (OCT) in emetropic and myopic cases was aimed. Material and Methods: The study group included a total of 224 cases (118 females, 106 males). Cases were divided into four groups: between 0.00/-0.75 D (first group=control group), between -1.00/-3.00 D (second group), between -3.25/-6.00 D (third group) and between -6.25/-12.00 D, according to their refractive error. Thickness of retinal nerve fiber layer (RNFL) and macula was measured using OCT. Results: While an increase was detected in foveal thickness and volume in the highly myopic group, a reduction was found in RNFL thickness of all areas except temporal area. Total macular volume, outer macular thickness and volume were also reduced. The highest thinning of RNFL in highly myopic cases was in 13.1% in superior and 18.6% in nasal thickness. There was a weak correlation between RNFL thickness, macular thickness and volume values and axial length/spheric equivalent. Conclusion: Assessment of especially nasal and superior quadrant thickness in RNFL is crucial in highly myopics. Distance between foveal pit and parafoveolar tip is inversely proportional with myopia, in other words, increase in degree of myopia causes macular area to become flatter.Öğe Ocular Changes Associated with Topiramate(TAYLOR & FRANCIS INC, 2011) Ozturk, Banu Turgut; Genc, Emine; Tokgoz, Mine; Kerimoglu, Hurkan; Genc, Bulent OguzPurpose: To determine the changes in refractive error, and the cornea, anterior chamber, and retina induced by topiramate. Methods: The study included 76 eyes of 38 patients that began to use topiramate due to migraine. Following ophthalmological examination, all of the patients underwent central corneal thickness (CCT), anterior chamber volume (ACV), anterior chamber depth (ACD), and anterior chamber angle (ACA) measurement using a Scheimpflug camera, as well as macular thickness, retinal and retinal nerve fiber layer thickness (RNFLT) measurements using optical coherence tomography (OCT). These procedures were repeated 15, 30, and 90 days after the initiation of topiramate therapy. Results: The median refractive error value showed a statistically significant increase from -0.25 diopters (D) to -0.62 D at the 90th day follow-up (P < 0.001). Mean CCT was 570.56 mu m before treatment and increased to 573.69 mu m at the 15th day follow-up, 575.31 mu m at the 30th day follow-up, and 574.56 mu m at the 90th day follow-up; however, these changes were not statistically significant. Mean ACV, ACD, and ACA did not exhibit statistically significant changes. Mean retinal thickness (RT) increased during the treatment from 263.46 mu m to 271.60 mu m, which was not statistically significant. The initial mean RNFLT was 100.56 +/- 15.36 mu m and significantly increased to 110.2 +/- 8.41 mu m and 111.03 +/- 14.59 mu m at the 30th and 90th day follow-ups, respectively (P = 0.01 and P = 0.004, respectively). Conclusions: During the 3-month follow-up of patients using topiramate 50 mg d(-1) significant myopic shift and an increase in RNFLT were observed. Further studies are warranted in order to assess the effects of topiramate when used long term and at higher doses.Öğe Topiramate-induced acute-onset myopia and central corneal thickening: Pentacam Scheimpflug imaging findings(CANADIAN OPHTHAL SOC, 2009) Kerimoglu, Hurkan; Tokgoz, Mine; Ozturk, Banu; Gonul, Saban; Pekel, Hamiyet[Abstract not Available]
