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    Effect on body weight of botilinum type-A toxin injection into submandibular salivary glands: An experimental study in the rabbit model
    (2013) Şahin, Mustafa; Erenoğlu, B.; Yılmaz, Hüseyin; Esen, H.; Tolu, A.; Acar, F.; Alptekin, Hüsnü
    Background: In this study, we investigated the effects of Botulinum type A toxin (Btx-A) injection into salivary glands on body weight at rabbits. Material and Methods: Forty five rabbits were used in this study, and were divided into three groups of 15 rabbits each, as follows: Group I: Control group , Group II: Btx-A was injected with a dosage of 50 IU into left submandibular gland., Group III: Btx-A was injected with a dosage of 50 IU into each of submandibular glands. The rabbits were weighed monthly. At the end of the 6 months, all animals were sacrificed. Small intestine and submandibular salivary glands were excised. The tissue sections was stained with hematoxylin-eosin and immunostained with primary antibodies for epidermal growth factor receptor (EGFR). The length of villi was measured, and the immunostained cells were counted. Results: Body weights measurement showed an increase of 65.2 % over the initial weight in group I, a decrease of 12.1 % in group II and a decrease of 30.6 % in group III (P<0.001). The villi length was 893±63 ? in group I, 712±30 ? in group II and 621±41 ? in group III (P<0.001). The mean immunostained cells count of submandibular glands was 527±90.7 in group I, 267.8±71.1 in group II and 260.2±76.4 in group III (P<0.001). The mean immunostained cells count of intestinal villi was 906.2±45.7 in group I, 786.4±75.6 in group II and 658±84.3 in group III (P<0.001). Conclusion: In this experimental study, Btx-A injection into submandibular salivary glands lead to intestinal villi atrophy and weight loss in rabbit model.
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    The Effects of Botox Injection to Salivary Glands on Weight Loss
    (John Wiley & Sons Ltd, 2010) Şahin, Mert; Erenoğlu, B.; Yılmaz, H.; Esen, H.; Tolu, A.; Acar, F.; Alptekin, Hüsnü
    [Abstract not Available]