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Öğe Apoptosis [Apoptosis ve Önemi](2002) Tosun M.; Kalkan S.Nowadays, there are too many studies about apoptosis which also named as physiological cell death, going on. Apoptosis, which is one of the very important regulatory mechanism to control so many equilibrium lasting at organism, is stimulated by heat, radiation, hormonal failure, toxins and lack of growth factors. Apoptosis has three main steps and if the death signal to stimulate apoptotic pathways being cut during first step, the cell will return to normal architecture. Otherwise, mitochondrial transmembran potential decreases and apoptotic process grow up via cytochrom-C and Smac/Diablo pathways but IAP activation. There are so many question related with apoptosis to wait for explanation. Being extensive studies, give us very important data about apoptosis and its importance.Öğe Histomorphologic evaluation of the development of the esophagus between 17 and 32 weeks old human fetuses [Özofagus'un geli?şi?mi?ni?n 17 i?le 32 haftalar arasindaki? fetuslerde hi?stomorfoloji?k olarak de?erlendi?ri?lmesi?](2005) Tuncer I.; Tosun M.; Kalkan S.; Soylu R.Purpose: The embryonic development of the esophagus progresses very complexly and systematically. The aim of this study was to the histological evaluation of the esophagus in 17-32 week old human fetuses. Material and Methods: 20 human fetuses whose ages ranged between 17-32 week-old and all of which were collected by University of Selcuk Meram Faculty of Medicine Department of Anatomy via spontaneous abortus under ethic rules were included in this study. The tissue samples of the esophagus were excised and processed with routine histologic methods, embedded in paraffin, stained with Hematoxylin-Eosin and evaluated light microscopically. Results: The histologic organization of the esophagus of the 17-20 week old fetuses was poor. However, the organization was accelerated after 21 weeks and almost finished after approximately 27 weeks. Conclusion: Fetal development of the esophagus accelerates after approximately 21 weeks and ending coarsely after 27 weeks.