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    Effects of caffeic acid phenethyl ester (CAPE) on sepsis in rats
    (SPRINGER/PLENUM PUBLISHERS, 2008) Tekin, Ahmet; Kuecuekkartallar, Tevfik; Tuerkyilmaz, Serdar; Dinckan, Ayhan; Esen, Hasan; Ates, Burhan; Yilmaz, Hueseyin
    Sepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related histopathological changes in the lung, liver and kidney in an experimental sepsis model. Forty Sprague Dawley rats were used in this study, and were divided into four groups of ten rats each, as follows: Group I was given intraperitoneal saline infusion treatment. Group II was given intraperitoneal CAPE infusion treatment. Sepsis was induced in the animals in Group III (sepsis with saline infusion), while Group IV rats underwent induced sepsis plus CAPE infusion treatment (sepsis with CAPE infusion). Sampling was performed 48 h after treatment. The induction of sepsis resulted in a significant increase in serum glucose, leukocytes, urea, creatinine, LDH levels in BAL, plasma MDA, AST and ALT levels in the sepsis+saline group. The use of CAPE significantly decreased these parameters. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the sepsis+CAPE group than in the other groups. These results support that CAPE may be used for the treatment of organ failure during sepsis.
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    Evaluation of the first 100 liver transplantations
    (TURKISH SOC GASTROENTEROLOGY, 2008) Dinckan, Ayhan; Tuerkyilmaz, Serdar; Tekin, Ahmet; Duman, Adil; Yilmaz, Aygen; Mesci, Ayhan; Ertug, Zeki
    Background/aims: We aimed to present the experience of the first 100 liver transplantations carried out at Akdeniz University. Methods: The data of 100 patients in pediatric and adult age groups who underwent liver transplantation at Akdeniz University Organ Transplantation Center between January 2000 and January 2007 were examined retrospectively. The cases between January 2000 and December 2003 were evaluated as the first term and those between January 2004 and January 2007 as the second term. Results: The mean age of the 100 patients (52M, 48F) was 38.6 +/- 17.3 (1-68) years. One-year and three-year survival rates of the patients were determined as 67.3% and 54.3% in the first term and 88.7% and 79.3% in the second term, respectively. Conclusions: With better comprehension of recipient and donor surgery technique, in addition to accumulation of knowledge and experience, the results in liver transplantation might be improved.