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  • Küçük Resim
    Öğe
    Akut gastroenterit tanılı hastalarda Campylobacter ve Salmonella türlerinin yeri ve antimikrobiklere duyarlılıkları
    (AVES, 2019) Çiftçi, Nurullah.; Türk-Dağı, Hatice.; Tuncer, İnci.
    Objective: Altough there are many microogranisms that might be the agents of gastroenteritis, routine laboratory tests can not determine all of them with our current techniques. This situation leads to failure of empirical treatment and to economical losses due to incorrect usage of antibiotics. In this study, we aim to investigate prevalence and antimicrobial susceptibility of Campylobacter and Salmonella from patients with acute gastroenteritis. Methods: Between 1 June 2015 and 31 May 2016, stool samples were inoculated on Campylosel agar (bioMerieux, Marcy l'Etoile, France) and GN enrichment broth (Merck, Darmstad, Germany). Campylosel agar incubated at 42 degrees C for 48-72 hours in microaerophilic atmosphere. After 6-8 hours incubation at 37 degrees C, GN enrichment broth was subcultured to EMB agar (Merck, Darmstad, Germany) and Hektoen enteric agar (Merck, Darmstad, Germany). In addition to conventional tests, matrixassisted laser desorption/ionization time-of-flight mass spectrometry confirmed the identification of Campylobacter- or Salmonella-suspected colonies. Antibiotic suscebtibility testing of Campylobacterspecies was carried out with gradient test (Etest 6 , bioMerieux, Marcy l'Etoile, France), and results were evaluated according to EUCAST criteria. Results: Pathogenic microorganisms were isolated in 67 (17.7%) of 379 stool cultures. 42 (62.7%) of them were identified as Campylobacter and 25 (37.3%) of them were identified as Salmonella. Of 42 Campylobacter strains, 41 were identified as C. jejuni, and one was identified as C. coll. 40 (95.2%) of Campylobacter strains were susceptible to erythromycin, 28 (66.7%) were susceptible to tetracycline, and 16 (38.1%) were susceptible to ciprofloxacin. Conclusions: Campylobacter species were the most commonly isolated bacteria as a causative agent of gastroenteritis and according to the antibiotic susceptibility test results erythromycin treatment is recommended for the patients.
  • Küçük Resim
    Öğe
    Klinik örneklerden soyutlanan Klebsiella pneumoniae suşlarında tigesikliğinin in-vitro aktivitesi
    (2006) Arslan, Uğur.; Işık, Ferhat.; Tuncer, İnci.
    Yeni bir glisilsiklin antibiyotik olan tigesiklin (GAR-936), çoğul ilaç dirençli türlerin de bulunduğu bir çok yaygın patojene karşı in-vitro etkili görünmektedir. Bu çalışmada, klinik örneklerden soyutlanan 50’si genişlemiş spektrumlu beta-laktamaz pozitif, 50’si negatif olan 100 Klebsiella pneumoniae suşuna karşı tigesiklinin in-vitro aktivitesi araştırılmıştır. Tigesiklin için MİK değerleri E-test metodu ile belirlenmiştir. Genişlemiş spektrumlu beta-laktamaz pozitif ve negatif K.pneumoniae suşları için tigesiklinin MİK50 ve MİK90 değerleri sırası ile 0.38-1 µg/ml ve 0.25-0.5 µg/ml olarak saptanmıştır. Suşların tümü tigesikline duyarlı bulunmuştur.