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Öğe Histological effects of zinc and melatonin on rat testes(COMENIUS UNIV, 2011) Tuncer, I; Sunar, F.; Toy, H.; Baltaci, A. K.; Mogulkoc, R.Background: The objective of this study is to examine the histological effects of zinc and melatonin, alone or in combination, on rat testes. Methods: For this purpose four study groups of ten Sprague-Dawley male rats were formed and treated for one month as follows: (1) Controls; (2) Rats injected with 3 mg/kg/day zinc, as zinc sulfate; (3) Rats injected with 3 mg/kg/day melatonin and (4) Rats injected with 3 mg/kg/day each zinc and melatonin. Results: After four weeks the rats treated with melatonin showed inhibited spermatogenesis, testicular tubular degeneration and necrosis, obstruction of tubular lumen and lymphocytic infiltration. The two zinc-treated groups showed no histological differences to controls but the melatonin-only group showed inhibited spermatogenetic activity, tubular degeneration and necrosis, as well as obstruction of tubule lumens and lymphocytic infiltration. Conclusion: The obtained results suggest that 4-week treatment with melatonin leads to histological and physiological impairments of testis and that zinc supplementation might offset these damaging effects (Tab. 2, Fig. 4, Ref. 12). Full Text in free PDF www.bmj.sk.Öğe Hyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: Protective role of melatonin(MAGHIRA & MAAS PUBLICATIONS, 2005) Mogulkoc, R; Baltaci, AK; Oztekin, E; Aydin, L; Tuncer, IOBJECTIVE: The present study aimed at determining how 3-weeks intraperitoneal melatonin administration affected oxidative stress caused by experimental hyperthyroidism. MATERIALS AND METHODS: The study was conducted on 30 male rats of Spraque-Dawley species. The experimental animals were divided to 3 groups (control, hyperthyroidism and hyperthyroidism+melatonin). The supplementation was continued for 3 weeks after which the animals were sacrified and tissue malondyaldehyde (MDA) and glutathione (GSH) levels were determined. RESULTS: MDA levels in kidney and testis tissues in hyperthyroidism group were higher than those in control and hyperthyroidism+melatonin administered groups (p < 0.001) and levels in hyperthyroidism + melatonin administered group were higher than those in the control group (p < 0.001). The highest GSH levels were obtained in hyperthyroidism + melatonin-administered group (p < 0.001) and GSH levels in hyperthyroidism group were higher than those in the control group (p < 0.001). CONCLUSION: Results of the study demonstrate that hyperthyroidism induced by 3-weeks L-thyroxine administration increased oxidative stress in kidney and testis tissues and that although melatonin administration inhibited this stress to a certain extent, it could not bring the stress down to the level in controls.Öğe Investigation of the bifurcation level of the common carotid artery and variations of the branches of the external carotid artery in human fetuses(ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2005) Zumre, O; Salbacak, A; Cicekcibasi, AE; Tuncer, I; Seker, MVariations in the position of the bifurcation of the common carotid artery (CCA) and the origin or branching pattern of the external. carotid artery (ECA) are well known and documented. In this study, the bifurcation levels of the CCA and origin variations of the branches of the ECA have been extensively investigated in human fetuses. Bilaterally, 40 carotid bifurcations and 40 ECA and their branches have been examined. A latex solution, which had been diluted with water at a ratio of 25% and colored with red India ink, was injected into the aortic arch. Fetuses were kept at room temperature for 24 h before the ECA and its branches were dissected under the microsurgery microscope. Cases of variation were determined and photographed. The bifurcation level of the CCA was determined to be 55% at the C-3 level, 35% at the C-4 level., 10% at the C-5 level on the right side and 60% at the C-3 Level., 40% at the C-4 level on left side. The distribution of the ECA trunks was determined as follows: A linguofacial trunk was present in 20% of the cases, a thyrolingual trunk in 2.5%, a thyrolinguofacial trunk in 2.5% and an occipitoauricular trunk in 12.5%. Beyond this the ascending pharyngeal artery (APA) was observed in one fetus to originate from the internal carotid artery (ICA). Knowledge of variations in the origin and course of the ECA and its branches is of great importance in surgery and radiological examinations. (c) 2005 Elsevier GmbH. All rights reserved.Öğe An investigation of the origin, location and variations of the renal arteries in human fetuses and their clinical relevance(URBAN & FISCHER VERLAG, 2005) Cicekcibasi, AE; Ziylan, T; Salbacak, A; Seker, M; Buyukmumcu, M; Tuncer, IWe investigated the origin, localizations and anatomic variations of the renal artery (RA) in human fetuses with the aim of determining the distribution of these variations according to lateralization and gender. In total, 90 fetuses of spontaneous abortion (45 mates, 45 females) with no congenital malformations were included to the study. The abdominal aorta and its branches were dissected after latex solution colored with red ink had been injected into the vessels from the thoracic aorta. In all., 180 RA dissections were performed bilaterally in 90 cases and the anatomic variations were photographed. Right and left RAs were found to originate from the following levels according to the columna vertebratis, respectively: 3.8% and 1.9% tower T-12, 67.3% and 25.0% upper L-1, 9.6% and 28.8% mid L-1, 15.3% and 40.3 lower L-1, 3.8% and 3.8% upper 1/3 part of L-2 vertebra. The right RA originated from the lateral part and anterolateral wall of the abdominal aorta in 73.0% and 26.9% of cases white the lateral. and anterolateral watt origin percentages of left RA were 90.3% and 9.6%, respectively. The origin site of the right RA from the abdominal aorta was superior to, at the same level with, and inferior to that of the left RA in 53.8%, 34.6% and 11.5% of the cases, respectively. There were no variations in 75% of the cases whereas the remaining 25% had several variation patterns. The presented morphological results are as follows: A single hilar artery in 75% of the cases, double hilar arteries in 11.1%, an inferior polar artery in 10.5%, and a superior polar artery in 3.3% of specimens studied. Anatomical variations were observed more frequently among mate fetuses and on the right side. Knowledge of RA variations is important for surgeons in performing many procedures and may help to avoid clinical. complications, especially, during radiological examination and/or surgical approaches in the abdominal. region. (c) 2005 Elsevier GmbH. All rights reserved.Öğe A rare variation of the coeliac trunk(URBAN & FISCHER VERLAG, 2005) Cicekcibasi, AE; Uysal, II; Seker, M; Tuncer, I; Buyukmumcu, M; Salbacak, AThe hepatic, splenic and left gastric arteries are considered as the "main classic branches" of the coeliac trunk. During the routine dissections in the laboratory of the Anatomy Department in a 62-year-old mate cadaver, a rare variation, a coeliacomesenteric trunk was observed. This trunk gave rise to the left gastric, the common hepatic, the splenic, the left gastro-epiploic, the right and Left inferior phrenic arteries. The developmental and clinical significance of this anomalous vessel is discussed. (c) 2005 Elsevier GmbH. All rights reserved.Öğe Urethral cultures in patients with spinal cord injury(NATURE PUBLISHING GROUP, 2004) Levendoglu, F; Ugurlu, H; Ozerbil, OM; Tuncer, I; Ural, OStudy design: Prospective analysis. Objectives: To investigate the colonization of the distal urethra and bladder during the initial stages of rehabilitation in acute spinal-cord injury(SCI) and to examine the association between bacteriuria and colonization of the distal urethra. Setting: Selcuk University Meram Faculty of Medicine, Konya, Turkey. Methods: A total of 27 patients with SCI (13 females and 14 males) and 40 controls without evidence of disease of the urinary tract were studied. Cultures were taken from the patients who applied clean intermittent catheterization and compared with normal subjects. Results: Escherichia coli was predominantly isolated from the urine and urethral cultures of both female and male SCI patients. Colonization of other bacteria in the urine and urethral cultures was similar in both female and male patients, except for Pseudomonas, which was colonized in male patients. In all, 72% of patients who had E. coli positive urethral cultures also had E. coli colonization in their simultaneous urine cultures. There was concordance between urethra and urine cultures concerning the growth of E. coli (P=0.82). When urethral cultures collected 1 week before were evaluated in patients with E. coli positive urine cultures (n=24 cultures), 15 of these urethral cultures also had E. coli colonization. There was concordance between urethra and urine cultures concerning the growth of E. coli (P=0.66). Conclusions: Our study suggested that urethral. ora was a significant source for the development of urinary infection in spinal cord-injured patients.Öğe The use of different levels of common vetch seed (Vicia sativa L.) in diets for fattening rabbits(ELSEVIER SCIENCE BV, 2003) Yalcin, S; Tuncer, I; Yalcin, S; Onbasilar, EEAn experiment was conducted to study the effects of various levels of common vetch seed (Vicia sativa L.) in the diet on the growth performance and some carcass characteristics of rabbits. In the experiment a total of 96 weaned New Zealand White rabbits aged 35 days and weighing on average 800 g were equally divided into four groups of 24 (six replicates of two male and two female rabbits each). Four levels (0, 10, 20 or 30%) of common vetch seed were included in isonitrogenous and isocaloric diets. The experimental period lasted 6 weeks. The average values of total live weight gain for control group. the first, second and third treatment groups were 950, 945, 826 and 848 g (P > 0.05), feed consumption values per kg live weight gain were 3.65, 3.63, 3.91 and 3.92 kg (P > 0.05), respectively. At the end of the experiment, there were no significant differences among the groups in live weight, live weight gain, feed consumption, feed efficiency, carcass yield and the percentages of liver, kidney, heart and lung. However the inclusion of 20 and 30% vetch seed in the diets decreased the weight gain by 13.04 and 10.76% and increased the feed consumption per kg weight gain by 7.12 and 7.40% compared to control group, respectively. The percentage values of head, skin and limbs, forelegs, hindlegs, breast and fibs, loin and abdominal wall were also not affected by these levels of vetch seed. It is concluded that common vetch seed can be given to the rabbits at the levels up to 10% of the diet without adverse effects on growth performance and carcass characteristics. (C) 2003 Elsevier B.V. All rights reserved.
