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Öğe Biochemical typing of Enterobacter isolated from several clinical materials [De?işik klinik örneklerden üretilen enterobacter'lerin biyokimyasal tip tayini.](1988) Tuncer I.; Ozsan K.A total of 74 Enterobacter species have been isolated from the patients applying to the department of Microbiology, University of Ankara, Studying several biochemical test systems their strains have been found. 37 of these Enterobacter species have been found to be Enterobacter cloacae, 10 Enterobacter agglomerans, 13 Enterobacter aerogenes, 3 Enterobacter hafniae (Hafnia alvei), 1 Enterobacter sakazakii. 2 of the strains couldn't be classified. In conclusion most of the strains were found to be Enterobacter cloacae.Öğe Developmental variations and clinical importance of the fetal thyroid gland: A morphometric study(2007) Cicekcibasi A.E.; Salbacak A.; Seker M.; Ziylan T.; Tuncer I.; Buyukmumcu M.Objetives: To investigate the morphologic structures and developmental anomalies of the thyroid gland in human fetuses. Methods: This study performed in the Department of Anatomy, Meram Faculty of Medicine between February and April in 2002. Fetuses were obtained from the Gynecology Department of the Meram Faculty of Medicine, Selçuk University, and Dr. Faruk Sukan Maternity Hospital (Konya, Turkey), Sixty spontaneously aborted fetuses (30 boys and 30 girls) between the ages of 13.5th and 32.5th weeks, which had no detectable anomalies, were evaluated. The gland was dissected under the microscope. The location of the gland was determined according to the tracheal ring levels and laryngeal cartilage levels. The length, width and thickness of both lobes and isthmus of the gland were measured and then, the developmental anomalies were noted. The obtained data were statistically analyzed by Least Squares in variant analysis. Results: Although there was no significant difference regarding to the gender for all parameters except in width of the right lobe (p<0.05), difference in the length and width of lobes and the length of isthmus between trimesters was significant (p<0.05). All measured parameters were increasing with advancing gestational age. The pyramidal lobe was observed in 18.3% of the cases. Conclusion: Normal dimensions and developmental anomalies of the fetal thyroid, which was shown in this study, may provide useful information for the prenatal diagnosis and in-utero treatment of thyroid dysfunctions.Öğe Genotype distribution of extended spectrum ?-lactamase producing Escherichia coli and Klebsiella pneumoniae(Scientific Publishers of India, 2015) Dagi H.T.; Al Dulaimi, Dhay Ali Azeez; Kuş, H.; Seyhan T.; Fındık, D.; Tuncer I.; Arslan U.Extended-spectrum beta-lactamase (ESBL) production is the most important cause of betalactam resistance in Gram-negative bacteria. Although it may also be found in other Gramnegative bacteria, ESBL is most commonly produced by Escherichia coli and Klebsiella pneumoniae strains. In this study, we aimed to investigate the distribution of ?-lactamase genes in ESBL-producing E. coli and K. pneumoniae strains. One hundred and twenty isolates of E. coli and K. pneumoniae isolated from clinical samples were used in this study. The identification and the antibiotic susceptibility tests were performed by VITEK 2 system in accordance with the manufacturer’s instructions. ESBL production was determined accoring to Clinical and Laboratory Standards Institute guidelines. The DNA isolation was performed with a commercial kit following company recommendations.blaTEM,blaSHV andblaCTX-M genes were amplified by multiplex PCR with specific primers. Of the 120 isolates collected, 84 isolates were of E. coli and 36 isolates were of K. pneumoniae.blaTEM gene was the most prevalent type (85.8%) followed byblaCTX-M (83.3%) andblaSHV (24.2%). NoblaSHV gene was detected in the E. coli strains. Among 120 ESBL-producing strains, 10.8% were susceptible to cefepime, 10.0% to ceftazidime, while 5.0% to ceftriaxone. In conclusion,blaTEM gene was the most frequently encountered ESBL of E. coli and K. pneumonia in our hospital. Further molecular surveillance and epidemiological studies of such resistant bacteria are recommended for monitoring and controlling the spread of ESBL producing strains. © 2015, Scientific Publishers of India. All rights reserved.Öğe Histomorphologic evaluation of the development of the esophagus between 17 and 32 weeks old human fetuses [Özofagus'un geli?şi?mi?ni?n 17 i?le 32 haftalar arasindaki? fetuslerde hi?stomorfoloji?k olarak de?erlendi?ri?lmesi?](2005) Tuncer I.; Tosun M.; Kalkan S.; Soylu R.Purpose: The embryonic development of the esophagus progresses very complexly and systematically. The aim of this study was to the histological evaluation of the esophagus in 17-32 week old human fetuses. Material and Methods: 20 human fetuses whose ages ranged between 17-32 week-old and all of which were collected by University of Selcuk Meram Faculty of Medicine Department of Anatomy via spontaneous abortus under ethic rules were included in this study. The tissue samples of the esophagus were excised and processed with routine histologic methods, embedded in paraffin, stained with Hematoxylin-Eosin and evaluated light microscopically. Results: The histologic organization of the esophagus of the 17-20 week old fetuses was poor. However, the organization was accelerated after 21 weeks and almost finished after approximately 27 weeks. Conclusion: Fetal development of the esophagus accelerates after approximately 21 weeks and ending coarsely after 27 weeks.Öğe Iliac horn [İli?ak boynuz](2003) Yensel U.; Mutlu M.; Özdemir H.M.; Tuncer I.Iliac horns are very rare bone variations. This variation confused with benign and malign disease of the bone in both clinical and radiological point of view. The majority of the iliac horns are associated with hereditery Nail-patella syndrome. Three iliac horn were found in anatomic bone survey. And we evaluated anatomomorphologic characteristics of the iliac horns and its orthopaedic associations.Öğe Late-onset Streptococcus pasteurianus sepsis in a preterm baby in a neonatal intensive care unit [Yenido?an yo?un bakım birimindeki erken do?muş bir bebekte geç başlangıçlı streptococcus pasteurianus sepsisi](Kare Publishing, 2014) Tarakçi N.; Da?i H.T.; U?ur A.R.; Tuncer I.; Taştekin A.Apnea, cyanosis, lethargy and prolongation in capillary filling time developed on the postnatal 37th day in a preterm baby who was born at the 30th gestational week with a birth weight of 1 300 g. Acute phase reactants and immature/total neutrophil count ratio were found to be high. The patient who was diagnosed with sepsis was successfully treated with meropenem which was started empirically. In his blood culture Streptococcus pasteurianus grew. S. pasteurianus is in the subgroup of streptococcus bovis which is one of the D group streptococci and its previous name is S. bovis type II/2. In the literature, there are very few cases of neonatal infection related with this bacterium. As far as we know, this is first case of neonatal sepsis caused by S. pasteurianus in Turkey. In addition, we tried to determine the clinical properties of neonatal infections arising from S. pasteurianus by reviewing the literature. © 2014 by Turkish Pediatric Association.Öğe Microbiologic analysis of some cosmetics on the market(1987) Ergun H.; Tuncer I.; Sengil A.Z.; Kirca N.K.[Abstract not Available]Öğe Microorganisms and their antibiotic resistances that isolated from the urine of urinary infection suspected patients(1988) Tuncer I.; Sengil A.Z.; Findik D.; Ergun H.; Gunaydin M.[Abstract not Available]Öğe MLST types of vancomycin-resistant enterococcus faecium strains isolated from blood cultures [Kan Kültürlerinden ízole Edilen Vankomisine Dirençli Enterococcus faecium Suşlarinin MLST Tipien](Ankara Microbiology Society, 2013) Arslan U.; DEMlR E.; ORYAŞlN E.; Da?i H.T.; Tuncer I.; Findik D.; Bozdo?an B.Enterococci, particularly vancomycin-resistant enterococci (VRE), are important nosocomial pathogens with limited treatment options. Enterococci have low-level resistance to penicillins and aminoglycosides and are intrinsically resistant to cephalosporins. In addition, they can acquire high-level resistance to beta-lactam antibiotics, aminoglycosides and glycopeptides. The aim of this study was to determine glycopeptide resistance mechanisms and genetic relationships of vancomycin-resistant EJaecium strains isolated from blood cultures between 2003-2009 years by molecular epidemiologic methods. A total of 38 VRE strains isolated from blood cultures were included in this study. The isolates were identified by conventional methods and Phoenix 100 BD automated system (Becton Dickinson Diagnostic Systems, USA) and confirmed by sequence analysis of 16S rRNA amplicons. Antibiotic susceptibility tests were performed by the Kirby-Bauer disk diffusion method accor-ding to the CLSI standards. MIC values of vancomycin were determined in vancomycin resistant strains by E-test (AB Biodisk, Sweden) method. Vancomycin resistance genes included vanA, vanB, vanC, and vanD were investigated by polymerase chain reaction (PCR) method. Clonal relationship between strains was determined by pulsed-field gel electrophoresis (PFGE). Sequence analysis was performed for examples selected for multilocus sequence typing (MLST) of each pulsotype and subtype. Thirty eight strains of enterococci isolated from blood cultures were defined as EJaecium by phenotypic methods and confirmed by 16S rRNA sequence analysis. Vancomycin MIC values of strains were determined as > 256 ?g/ml by E test. The vanA gene was detected in all isolates. Clonal relationship of 38 isolates E.Faecium carrying the vanA gene was determined by PFGE and MLST methods. PFGE detected four pulsotypes (A-D) and one sporadic isolate. Twenty nine strains belonged to A pulsotype, three strains belonged to B pulsotype, two strains belonged to C pulsotype and three strains belonged to D pulsotype. Out of 29 isolates, eight strains were type Al, nine strains were type A2, six strains were type A3, two strains were type A4 and four strains were type A5. MLST identified four different sequence types (STs). Twenty nine A pulsotype and its subtypes belonged to ST117 (76.3%), three B pulsotype belonged to ST280 (7.9%), two C pulsotype belonged to ST18 (5.2%) and three D pulsotype belonged to STI7 (7.9%). In conclusion, bloodstream infections caused by VRE in our hospital arose from a dominant strain belonged to ST117. However, presence of different pulsotypes of this strain indicated that the strain had been present in the hospital for a long time and had accumulated genetic variations. In addition, infections caused by minor pulsotypes were also detected. Therefore for prevention and control of the spread of nosocomial infections caused by VRE, it is crucial to identify resistance patterns and clonal relationship of these organisms.Öğe A Morphometric Evaluation of Some Important Bony Landmarks on the Skull Base Related to Sexes(2004) Çiçekcibaşi A.E.; Murshed K.A.; Ziylan T.; Şeker M.; Tuncer I.The purpose of this study is to evaluate the morphometric measurements of some important bony landmarks on the cranial base and to determine their relationships between the sexes and their bilateral differences. In this study, 60 (34 male and 26 female) skulls were obtained from the teaching skeletal collections at the Anatomy Department of Meram Medical School, Selçuk University. The axial length of the occipital condyles (ALOC), the anterior intercondylar distance (AICD), the sagittal intercondylar angle (OICA), the transverse and sagittal diameters of the jugular foramen (TDJF) and (SDJF), the distance from the apex of the mastoid process to the outer border of the jugular foramen (MJ), the distance from the apex of the mastoid process to the outermost lateral point of the foramen magnum (MFM) and the distance from the apex of the mastoid process to the center of the external opening of the carotid canal (MCF) were measured by using a millimetric sliding caliper and a goniometer. Student's t-test was used to compare the male-female and right-left measurements. To determine the relationships between the studied parameters, Pearson correlation coefficients were calculated. The results showed that the ALOC of both sides and the AICD parameters were significantly longer in males than in females (P < 0.01). Bilateral differences in the studied parameters showed that the measurements on the right side were significantly greater than those on the left in the MCF, MFM, SDJF and TDJF. Significant associations were found among some of the studied measurements. We believe that the results of this study may be useful in cases of cranial base surgery, moreover a knowledge of the anatomical relationships and features of this region is very important for surgical approaches.Öğe Short communication: Extended-spectrum beta-lactamase production in Klebsiella pneumoniae strains isolated from bloodcultures and their antibiotic susceptibilities [Kisa bildiri: Kan kültürlerinden izole edilen Klebsiella pneumoniae suşlar?nda genişlemiş spektrumlu beta-laktamaz varl??? ve antibiyotik duyarl?l?klar?](2008) Işik F.; Arslan U.; Tuncer I.This study was carried out to detect the extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae strains isolated from blood cultures of hospitalized patients, and to determine their antimicrobial susceptibilities. A total of 102 K.pneumoniae strains isolated from blood samples were taken in the study, and ESBL production and susceptibilities to amikacin, gentamicin, imipenem, ciprofloxacin, amoxicillin/clavulonate (AMY/CA), ceftazidime, ceftriaxone, trimethoprim/ sulphametoxazole (TMP-SMX), piperacilin-tazobactam (PIP/TAZ) and chloramphenicol were investigated by using E-test (AB Biodisk, Sweden). ESBL positivity was observed in 65 (63.7%) of the isolates, and all of the strains were found susceptible to imipenem. The resistance rates of ESBL-producing isolates were detected as 27.7% for amikacin, 41.5% for chloramphenicol, 49.2% for TMP-SMX, 55.4% for ciprofloxacin and 60% for PIP/TAZ; whereas these rates for ESBL non-producers were 2.7%, 5.4%, 5.4%, 2.7%, and 13.5%, respectively. Both the resistance rates and MIC values (MIC50 and MIC90) of the tested antimicrobial agents except imipenem, were found higher in ESBL positive strains than the ESBL negative strains (p<0.05). The results of this study, in accordance with the previous national and international reports, indicated high rate of ESBL positive K.pneumoniae and also increased rate of antimicrobial resistance in such strains. Clinical microbiology laboratories should put ESBL detection tests into practice and each hospital should determine their antibiotic treatment policies according to their data.
