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    Clomipramine Versus Sertraline in the Treatment of Obsessive Compulsive Disorder
    (1999) Askin, R.; Turan, M.; Cilli, A. S.; Kaya, N.
    Objective: The aim of this study was to compare the efficacy, safety, and tolerability of sertraline and clomipramine in the treatment of obsessive-compulsive disorder (OCD). Method: Outpatients met the DSM-IV criteria for OCD for 1 year or longer and scores of ? 20 on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and ? 4 on the Clinical Global Impression Severity Scale (CGI-S) were included in the study. Patients who had significant concomitant physical disease, suicidal tendency, a history of seizure or organic brain disorder, substance abuse within the previous sixth months, DSM-IV axis I diagnoses other than OCD and who had had medication for 1 month were not included in the study. Patients were randomized to receive 8-week of single-blind treatment with either fixed dose of sertraline (n=20) 50 mg/day or clomipramine (n=22) initially 50 mg/day and 150 mg/day after 1 week. No additional medication was given to patients. Clinical evaluations were conducted before the treatment and on two-week schedule throughout the 8-week trial using the Y-BOCS and theCGI-S. Results: Four of clomipramine (18.2%) and 2 of sertraline (10.0%) patients dropped out because of adverse events or lack of effectiveness. Thirty six patients completed the trial (sertraline n=18; clomipramine n=18). The mean baseline Y-BOCS and CGI-S scores were 24.95 and 4.75 respectively for sertraline and 23.54 and 4.85 for clomipramine (p>0.05). A significant reduction in OCD symptoms from baseline to the end of 8 th week of the trial was found in both sertraline and clomipramine treated groups (p<0.05). Mean baseline to final visit changes were -69.06% (Y-OBCS) and -65.75% (CGI-S) for sertraline and -69.26% (Y-OBCS) and -53.78% (CGI-S) for clomipramine (p>0.05). The number of patients withdrawn because of adverse events was substantially greater for clomipramine (22.2%) than sertraline (11.1%). The incidence of side effects was significantly higher in clomipramine-treated patients versus sertraline-treated patients. The most frequent adverse events with sertraline were headache (38.8%), nausea (33.3%), irritability (11.1%) and tremor (11.1%), while clomipramine was most commonly associated with dry mouth (50%), weight gain (50%), constipation (27.7%), yawning (27.7%), sedation (22.2%) and dizziness (11.1%). Conclusions: At fixed doses, both clomipramine and sertraline showed a similar therapeutic efficacy in the treatment of OCD. Clomipramine produced more side effects and dropout rate. The results indicate that sertraline is as effective as clomipramine in the treatment of OCD and is better tolerated.
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    Effect of Duration of Macular Detachment on Early Visual Acuity Results in Macula of Rhegmatogenous Retinal Detachments
    (2009) Kerimoğlu, H.; Adam, M.; Turan, M.; Öztürk, B.; Pekel, H.; Okudan, S.
    Purpose: To evaluate the effect of the duration of macular detachment on best corrected visual acuity in eyes with rhegmatogenous retinal detachment treated with pneumatic retinopexy. Materials and Methods: The charts of patients with rhegmatogenous retinal detachment who had macular detachment within 2 weeks period and treated succesfully with pneumatic retinopexy between May 2006 and May 2009 in our clinic were reviewed retrospectively. 47 eyes were grouped according to their duration of macular detachment as eyes treated within 1-5 days (21 eyes), 6-10 days (14 eyes) and 11-14 days (12 eyes) and also grouped as eyes treated within first week (26 eyes) and second week (21 eyes) and the best corrected visual acuity 3 months after the operation was compared among the groups. Results: There was a significant difference between visual acuities of the 3 groups divided as 1-5, 6-10 and 11-14 days according to duration of macular detachment (p<0.001, Kruskal Wallis test). The difference between visual acuities of eyes treated within first week (0.56±0.19) and second week (0.32±0.13) was also significant (p<0.001, Mann-Whitney test). Conclusion: Postoperative visual acuity decreases while the duration of macular detachment increases in eyes treated with pneumatic retinopexy assessed in 3 and 2 time periods. Duration of macular detachment is an important prognostic factor for the prediction of postoperative visual acuity.