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Öğe Disseminated intravascular coagulation in cattle with abomasal displacement(KLUWER ACADEMIC PUBL, 2005) Irmak, K; Turgut, KThe purpose of the study was to evaluate haemostatic function in cattle with abomasal displacement (AD) and to reflect the occurrence of disseminated intravascular coagulation (DIC). Ten adult cattle with left displacement of abomasum (LDA) (group I), 10 adult cattle with right displacement of abomasum with volvulus (RDA) (group II) and 10 clinically healthy adult cattle (control group) were used as material. Numbers of platelets (PLT) and coagulation tests (activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), serum fibrin/fibrinogen degradation products (FDPs), fibrinogen) were measured before the surgical treatment of cattle with LDA and RDA. APTT was prolonged only in group II compared with the control and group I (P<0.05). However, when the individual values of coagulation profiles of each cow were evaluated, two cattle in group I and three cattle in group II had at least three abnormal coagulation profiles, which reflect the occurrence of DIC. These cattle died after surgical treatment. The two cattle with LDA had abnormal APTT, FDPs and PLT values; three cattle with RDA had abnormal APTT, PT, TT, FDPs and PLT values. APTT (5 cases), FDPs (5 cases) and thrombocytopenia (5 cases) were the three most common abnormal tests on coagulation profile in the cattle with LDA and RDA. The results of the study indicate that cattle with AD had a spectrum of haemostatic dysfunction and that DIC was a significant risk factor for mortality.Öğe Effects of nutritional therapy or N-acetyl-cysteine (NAC) treatment on biochemical markers and liver histology in dogs with CCL4-induced hepatic necrosis(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2005) Sen, I; Turgut, K; Ok, M; Kiran, MM; Guzelbektes, H; Ortatatli, M; Birdane, FMThe purpose of this study is to evaluate the potential beneficial effects of nutritional therapy or N-acetyl Cysteine (NAC) treatment on hepatic necrosis experimentally induced by CCL4 in dogs. Eighteen healthy mixed breed dogs of both sexes were randomly divided into 3 equal groups and received a single oral dose of CCL4 (2.5 ml/kg body weight). Dogs of control group and of experimental group I were fed with maintenance diet (Hills) and with canine prescription k/d diet (Hills) respectively, once a day. Dogs of the experimental goup II were fed with maintenance diet and were treated by NAC (140 mg/kg in the first oral dose followed by 70 mg/kg 6 hours later for 30 days). Serum enzyme (ALT and ALP) activities and bilirubin concentrations (total and direct) were monitored on the 1(st), 5(th), 10(th), 20(th) and 30(th) days. Ultra-sonographies, BSP clearance and liver biopsies for histological evaluation were performed on the 10(th), 20th and 30th days. Marked increases of serum enzyme activities were noticed since the 1(st) day and persisted until the 15th - 20th days in all CCL4-intoxicated dogs. Total and unconjugated bilirubin concentrations also slightly increased in serum of control dogs and dogs of the experimental group I (nutritional therapy) from the 1(st) day to the 15th day, whereas in dogs treated by NAC, significant fluctuations have persisted until the 30(th) day. BSP retention rates were markedly extended from the 1(st) to the 20(th) days in all groups, but the BSP clearance was significantly more depressed in control dogs and in dogs treated by NAC than in those received nutritional therapy (p < 0.05). Morphological changes (hyperechogenicity of the liver parenchyma) and tissue lesions (hydropic degeneration and hepatic necrosis) were evidenced in all dogs. Nevertheless, degenerative changes were less severe (only grades 1 and 2, particularly on the 20(th) and 30(th) days) and were associated with an increase of hepatocyte regeneration in experimental group II. These results showed that the intensity of liver injure could be assessed through BSP retention test and histological analysis and that nutritional therapy, not NAC treatment. partially attenuated CCI4 - hepatotoxicity in dog.Öğe Renal cell carcinoma in a dog: Pathologic and cytologic findings(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2004) Birdane, FM; Hatipoglu, F; Ortatatli, M; Koc, Y; Turgut, KThis study presents a dog with a history of anorexia, vomiting and abdominal distention of one week duration. Abdominal palpation revealed a mass in the right abdominal quadrant. Laboratory abnormalities included slight anaemia, leukocytosis, thrombocytosis, hypoalbuminaemia, hypokalaemia, hypocalcaemia and metabolic acidosis. Urine was reddish in color with 3+ protein and blood reaction, 2+ leukocyte, and 2+ glucose. Erythrocytes and leukocytes casts and innumerous renal and transitional epithelial were present. Ultrasonographic examination revealed a solitary mass taking the place of right kidney. Urine sediment cytology revealed large clusters of markedly pleomorphic cells. Mitotic figures in some cells were observed. A large tumour mass was found at laparotomy. The right kidney was replaced by this massive ball shaped tumour. Unilateral nephrectomy was performed and renal cell carcinoma was diagnosed by microscopic examination.Öğe Serum GGT and ALP enzyme activities in calves with failure of passive transfer of antibody(INDIAN VETERINARY JOURNAL, 2003) Sevinc, M; Sen, I; Irmak, K; Turgut, K[Abstract not Available]
