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    The evaluation of coagulation profiles in spontaneous premature calves with respiratory distress syndrome
    (KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2011) Irmak, Kemal; Turgut, Kursat
    The aim of this study was to determine coagulation profiles of spontaneous premature calves with respiratory distress syndrome. The study involved spontaneous premature calves with respiratory distress syndrome (n= 20) and clinically healthy newborn calves (n= 10). Blood samples were collected from all calves within the period between 2nd and 12th h of delivery to determine platelets (PLT), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), serum fibrin/fibrinogen degradation products (FDPs), and fibrinogen. Premature calves had prolonged APTT (P < 0.001) and PT (P < 0.01), decreased fibrinogen concentration (P < 0.001) and decreased platelet counts (P < 0.001) when compared to controls. An insignificant prolondation of TT was observed in 8 premature calves and two of which had also FDPs when compared to control calves. Abnormal, but insignificant findings of FDPs were noted in six premature calves with respiratory distress syndrome when compared to healthy calves. As a result, premature calves with respiratory distress syndrome had abnormal coagulation profile and seven of these died despite intensive therapy. The veterinarian should take these results in consideration when dealing with premature calves with respiratory distress syndrome and constitute an appropriate treatment. Additionally, these findings may be of value in forming bases for future studies.
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    Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs
    (ELSEVIER SCIENCE BV, 2007) Sevinc, Ferda; Turgut, Kursat; Sevinc, Mutlu; Ekici, Ozlem Derinbay; Coskun, Alparslan; Koc, Yilmaz; Erol, Muharrem
    The objective of this study was to evaluate the therapeutic and prophylactic efficacy of imidocarb dipropionate (IMDP) against babesiosis and to determine specific antibodies against Babesia ovis in experimentally infected lambs. Thirty-six 6-month-old splenectomized lambs were used. The lambs were randomly divided into six groups with six animals each, and were intravenously inoculated with 50 mL B. ovis-infected erythrocytes as follows: group I (therapy group) was treated with IMDP (1.2 mg/kg body weight) starting on the day of onset of clinical signs of babesiosis after the inoculation; group II (untreated control animals) was not treated with any therapeutic treatment after the inoculation; groups III, IV, V and VI (prophylaxis groups) were administered IMDP (2.4 mg/kg body weight) 1, 2, 3 and 4 weeks before the inoculation, respectively. The animals were housed in a tick-proof room with water and food ad libitum up to the 30th day post-inoculation (PI). The lambs were monitored from the first day PI by recording the manifestation of clinical disease, rectal temperature, and the degree of parasitaemia. All the lambs became infected with B. ovis, except five animals from group III, which were treated I week prior to experimental infection. Other animals showed signs of acute clinical babesiosis. The animals treated with IMDP (group I) were able to clear the parasite from the blood circulation after 48 h post-treatment. The recrudescence of B. ovis was observed in two lambs 7 days after treatment, and they were treated with the second similar dose of the drug. Six lambs (1, 1, 2 and 2 lambs in group III, IV, V and VI, respectively) from the prophylaxis groups died within 7-17 days after showing high parasitaemia and clinical symptoms of the disease. Regardless of the clinical symptoms, 83.30% and 66.66% of the lambs which were administered IMDP 1-2 and 3-4 weeks before, were determined to be protected against the virulent field strain of B. ovis. (C) 2007 Elsevier B.V. All rights reserved.