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    Assessment of In vitro Antibacterial Activity and Cytotoxicity Effect of Nigella sativa Oil
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) Ugur, Ayse Ruveyda; Dagi, Hatice Turk; Ozturk, Bahadir; Tekin, Gulsum; Findik, Duygu
    Background: Methicillin resistance is a serious health concern since it has spread among Staphylococcus aureus and coagulase-negative Staphylococci (CoNS) that are frequent community and nosocomial pathogens worldwide. Methicillin-resistant strains are often resistant to other classes of antibiotics, making their treatment difficult. Nigella sativa oil is known to be active against Gram-positive cocci, yet its in vitro cytotoxicity is rarely investigated, is a proper and powerful candidate for treatment of methicillin-resistant isolates. Objectives: The aim of this study is to evaluate the in vitro antibacterial activity and cytotoxicity effect of N. sativa oil. Materials and Methods: The minimal inhibitory concentrations (MICs) of N. sativa oil were determined by broth microdilution method against four different American Type Culture Collection strains, 45 clinical isolates of methicillin-resistant S. aureus (MRSA), and 77 methicillin-resistant CoNS (MRCoNS). The effects of different dilutions (0.25 mu g/mL, 0.5 mu g/mL, and 1 mu g/mL) of N. sativa oil on the proliferation of gingival fibroblasts were evaluated. Results: The MIC values of N. sativa oil against clinical isolates of Staphylococci were between < 0.25 mu g/mL and 1.0 mu g/mL. Compared to the control group, there was no cytotoxic effect on the proliferation of the gingival fibroblasts. Conclusion: In the present study, the oil of N. sativa was very active against MRSA and MRCoNS and had no in vitro cytotoxicity at relevant concentrations. These findings emphasize that there is a requirement for further clinical trials on N. sativa oil for "safe" medical management of infections caused by methicillin-resistant Staphylococci.
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    Enterococcus avium Peritonitis in a Child on Continuous Ambulatory Peritoneal Dialysis
    (MULTIMED INC, 2014) Ugur, Ayse Ruveyda; Findik, Duygu; Dagi, Hatice Turk; Tuncer, Inci; Peru, Harun
    [Abstract not Available]
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    Identification of bacterial vaginosis-associated bacteria in male urethra: Co-occurrence of Atopobium vaginae and Gardnerella vaginalis
    (MALAYSIAN SOC MICROBIOLOGY, 2019) Ugur, Ayse Ruveyda; Tuncer, Emine Inci; Findik, Duygu
    Aims: Bacterial vaginosis (BV) is characterized by a transition in vaginal microflora from lactobacilli to anaerobic bacteria. Gardnerella vaginalis and Atopobium vaginae are considered the most responsible pathogens for the etiology of BV. Colonization of male urethra with BV-associated bacteria has been rarely investigated. The aim of this study was to investigate the differences in the presence of BV-associated bacteria in the healthy male urethra in regard to sexual exposure. Methodology and results: The first-catch urine specimens, representative of urethral swabs, from 114 healthy male volunteers, were included in this study. Lactobacillus spp., L. crispatus, L. jensenii, L. gasseri, L. iners, G. vaginalis, A. vaginae, Peptoniphilus spp., P. lacrimalis, BVAB2, Mageeibacillus indolicus, Megasphaera type I, Mobiluncus mulieris, Leptotrichia/Sneathia, Corynebacterium spp., and Prevotella spp. were investigated using a PCR assay. The most frequently identified BV-associated bacteria were Lactobacillus spp., Peptoniphilus spp., and G. vaginalis. There was no association between any BV-associated bacteria and sexual exposure. There was statistically significant co-occurrence of A. vaginae and G. vaginalis in the MU of subjects independently of sexual exposure (p = 0.025). Also, there was a significant association between G. vaginalis and smoking (p = 0.023). Conclusion, significance and impact of study: To the best of our knowledge, this is the first study reporting the co-occurrence of G. vaginalis and A. vaginae in the male urethra independently of sexual exposure.