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Öğe Disability, depression and quality of life among elderly hemodialysis patients(OXFORD UNIV PRESS, 2005) Altıntepe, Lütfullah; Levendoğlu, F; Turk, S; Ugurlu, H; Guney, I; Atalay, H; Tonbul, Halil Zeki[Abstract not Available]Öğe Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury(LIPPINCOTT WILLIAMS & WILKINS, 2004) Levendoglu, F; Ogun, CO; Ozerbil, O; Ogun, TC; Ugurlu, HStudy Design. Prospective, randomized, double blind, placebo-controlled, crossover clinical trial. Objectives. To determine the efficacy of gabapentin in the treatment of neuropathic pain related to spinal cord injury. Summary of Background Data. Neuropathic pain is initiated or caused by a primary lesion or dysfunction in the nervous system. Neuropathic pain associated with spinal cord injury is quite refractory, and current treatments are not effective. Gabapentin, an anticonvulsant, has become the first choice in the treatment of neuropathic pain. The place of gabapentin in the treatment of spinal cord injury-related neuropathic pain was questioned in only a few recent reports; however, they are retrospectively designed, nonstandardized, and uncontrolled studies, or involve a very small series of patients using less than optimum doses. Methods. A total of 18-week study period included a 4-week medication/ placebo titration period. This was followed by a 4-week stable dosing period when the patients continued to receive maximum tolerated doses, a 2-week washout period, then a crossover of 4 weeks of medication/ placebo titration, and another 4 weeks of stable dosing period. Twenty paraplegic patients (female/male: 7/13) with complete spinal cord injury at the thoracic and lumbar level, aged between 20 and 65 years, with neuropathic pain for more than 6 months were recruited for the study. Results. All patients completed the study. Gabapentin reduced the intensity as well as the frequency of pain, relieved all neuropathic pain descriptors except the itchy, sensitive, dull, and cold types, and improved the quality of life ( P < 0.05). Conclusions. Gabapentin can be added to the list of first-line medications for the treatment of chronic neuropathic pain in spinal cord injury patients. It is a promising new agent and offers advantages over currently available treatments.Öğe Urethral cultures in patients with spinal cord injury(NATURE PUBLISHING GROUP, 2004) Levendoglu, F; Ugurlu, H; Ozerbil, OM; Tuncer, I; Ural, OStudy design: Prospective analysis. Objectives: To investigate the colonization of the distal urethra and bladder during the initial stages of rehabilitation in acute spinal-cord injury(SCI) and to examine the association between bacteriuria and colonization of the distal urethra. Setting: Selcuk University Meram Faculty of Medicine, Konya, Turkey. Methods: A total of 27 patients with SCI (13 females and 14 males) and 40 controls without evidence of disease of the urinary tract were studied. Cultures were taken from the patients who applied clean intermittent catheterization and compared with normal subjects. Results: Escherichia coli was predominantly isolated from the urine and urethral cultures of both female and male SCI patients. Colonization of other bacteria in the urine and urethral cultures was similar in both female and male patients, except for Pseudomonas, which was colonized in male patients. In all, 72% of patients who had E. coli positive urethral cultures also had E. coli colonization in their simultaneous urine cultures. There was concordance between urethra and urine cultures concerning the growth of E. coli (P=0.82). When urethral cultures collected 1 week before were evaluated in patients with E. coli positive urine cultures (n=24 cultures), 15 of these urethral cultures also had E. coli colonization. There was concordance between urethra and urine cultures concerning the growth of E. coli (P=0.66). Conclusions: Our study suggested that urethral. ora was a significant source for the development of urinary infection in spinal cord-injured patients.Öğe Ventricular function abnormalities in active rheumatoid arthritis: a Doppler echocardiographic study(SPRINGER HEIDELBERG, 2004) Levendoglu, F; Temizhan, A; Ugurlu, H; Ozdemir, A; Yazici, MObjective: The aim of the present study was to evaluate cardiac involvement in patients with active rheumatoid arthritis (RA). Methods: Forty patients with active RA participated. All were submitted to standard Doppler echocardiography and myocardial performance index (MPI) grading. Results: There were left and right ventricular diastolic function abnormalities in RA patients. Left ventricular MPI was also significantly higher than in controls (P < 0.05). A relationship was found between left ventricular early diastolic (E)/atrial (A) flow velocities (E/A ratio), isovolumic relaxation time (IRT), and disease duration (r = -0.47 and P = 0.002, r = 0.618 and P = 0.000, respectively). Conclusion: Diastolic function was impaired in both ventricles in patients with active RA. There was a direct relationship between some of the parameters of left ventricular diastolic function and disease duration as well. These findings suggest a subclinical myocardial involvement in RA patients.
