Yazar "Uney, K" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Effect of pentoxifylline on antioxidant status of healthy and endotoxemic New Zealand white rabbits(VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2005) Keskin, E; Oztekin, E; Col, R; Sivrikaya, A; Uney, K; Yazar, EIn this study, effect of pentoxifylline on antioxidant status of healthy and endotoxemic rabbits was investigated. Endotoxemia was induced with E. coli lipopolysaccharide in New Zealand white rabbits. Forty rabbits were randomly divided into four equal groups. Group 1 served as control. Animals in Group 2 were given lipopolysaccharide (400 mu g/kg) intravenously, in Group 3 pentoxifylline (50 mg/kg) was injected intraperitoneally. In Group 4; pentoxifylline (50 mg/kg intraperitoneally) and lipopolysaccharide (400 mu g/kg, intravenously) were injected simultaneously. Animals were killed, and liver, heart and kidney samples were taken at 6 hours after administrations. Malondialdehyde, superoxide dismutase, glutathione peroxidase and reduced glutathione levels of heart, liver and kidney tissues were measured. Lipopolysaccharide caused significant increases (p < 0.05) in hepatic malondialdehyde, and cardiac, hepatic and renal glutathione peroxidase activities. It however, caused significant (P < 0.05) decrease in hepatic superoxide dismutase activity when compared to control group. Pentoxifylline caused significant (p < 0.05) increases of cardiac and hepatic malondialdehyde levels, cardiac superoxide dismutase and renal glutathione peroxidase activities, and cardiac, hepatic and renal reduced glutathione levels when compared to control group. As a result, pentoxifylline has no exactly beneficial effect on the antioxidant status of healthy and endotoxaemic New Zealand white rabbits at the administered dose and route. Although it was stated that pentoxifylline may be beneficial in endotoxaemia, its antioxidant effect may be dependent on dose, administration route and animal species. For this reason, when pentoxifylline is used in endotoxaemia, a treatment protocol should be done for each animal species.Öğe Effect of pentoxifylline on biochemical parameters in endotoxaemic New Zealand white rabbits(NATL VETERINARY RESEARCH INST, 2004) Yazar, E; Col, R; Uney, K; Atalay, B; Elmas, M; Tras, BEffect of pentoxifylline on biochemical values in endotoxaemic rabbits was investigated. Forty rabbits were divided into four equal groups. Group 1, served as a control group, group 2: lipopolysaccharide was injected intravenously, group 3: pentoxifylline was injected intraperitoneally, group 4: lipopolysaccharide and pentoxifylline were injected simultaneously. Serum samples were collected 6 h after the treatments. Serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, total bilirubin, creatinine, urea, glucose, total protein, albumin, triglyceride, cholesterol, sodium, potassium, chloride, phosphorus and magnesium levels were measured. Pentoxifylline induced protective effect on the liver and kidney in endotoxaemia, but did not show any protective effect on lipid metabolism.Öğe Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits(SPRINGER, 2006) Elmas, M; Yazar, E; Uney, K; Karabacak, AThe pharmacokinetics of flunixin were determined after intravenous bolus injection at a single dose (2.2 mg/kg) in healthy rabbits and diseased rabbits with Escherichia coli lipopolysaccharide-induced septic shock. Six adult New Zealand White rabbits were used. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were best described by a two-compartment open model. In healthy rabbits, there was a high plasma clearance (0.62 L/(h kg)), and a relatively short elimination half-life (1.19 h). In endotoxaemic rabbits, total plasma clearance (0.43 L/(h kg)) was significantly lower (p < 0.05), and elimination half-life (1.90 h) and AUC(0-infinity) (5.29 (mu g h)/ml) were significantly higher (p < 0.05) than in healthy animals. The changes of pharmacokinetics of flunixin in rabbits with septic shock could be of clinical significance, and may require monitoring of plasma flunixin levels in endotoxaemic status.Öğe Pharmacokinetics of flunixin-meglumin following intravenous administration in Angora rabbits(NATL VETERINARY RESEARCH INST, 2005) Elmas, M; Uney, K; Karabacak, A; Yazar, EThe pharmacokinetics of flunixin-meglumin were determined after intravenous bolus injection at two different doses (1.1 and 2.2 mg/kg body weight) in rabbits. Six healthy adult Angora rabbits were used in the experiment. Blood samples were collected at 10, 20, 30, 45 and 60 min, 2, 4, 6, and 8 h after injection. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were described by a two-compartment open model. The area under the curve, contrary to other pharmacokinetic parameters, showed statistically significant differences between the two doses used (P < 0.05). The data obtained for the low and high doses were as follows: the elimination half-lives were 1.4 and 1.7 h, the volume of distribution - 0.6 and 0.8 L/kg, and total body clearance - 0.32 and 037 mL/h/kg body weight, respectively. The present study has shown that the pharmacokinetic variables of fluxin-meglumin in Angora rabbits are dose independent in the dose range of 1.1-2.2 mg/kg body weight.