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Öğe ADMA and total oxidant status in saliva(WILEY-BLACKWELL, 2013) Unlu, A.; Taner, A.; Unlu, N.; Ure, Z.; Korucu, E. N.[Abstract not Available]Öğe Antithrombin-III, MPV and plasma total homocysteine levels in Behcet's disease(WILEY-BLACKWELL, 2016) Akyürek, F.; Akyürek, Fatma Tuncez; Özdemir, M.; Vatansev, H.; Unlu, A.[Abstract not Available]Öğe Association between TSH status and genotypes of E23K polymorphism in KCNJ11 with gestational diabetic individuals(WILEY-BLACKWELL, 2016) Tok, M.; Menevse, E.; Arikoglu, H.; Unlu, A.; Kaya, D. Erkoc[Abstract not Available]Öğe Brefeldin A exerts differential effects on various phenotypes of breast cancer cell lines(WILEY-BLACKWELL, 2016) Tekin, G.; Ozturk, B.; Ozer, E. K.; Bariskaner, H.; Unlu, A.[Abstract not Available]Öğe CLINICAL IMPORTANCE OF B2 GLYCOPROTEIN I ANTIBODIES IN BCR-ABL NEGATIVE MYELOPROLIFERATIVE NEOPLASMS(FERRATA STORTI FOUNDATION, 2016) Kocak, M. Z.; Dagli, M.; Kutlucan, A.; Basturk, A.; Unlu, A.; Acar, H.; Kutlucan, L.[Abstract not Available]Öğe The Effect of Diazepam on the Development of Neural Tube Defects in Early Chick Embryos(Turkish Neurosurgical Society, 1999) Guney, O.; Selcuki, M.; Unlu, A.; Bagdatoglu, C.This study reveals the effects of diazepam on the development of neural tube defects in the chick based on light microscopy and histopathological study. Thirty fertile Hubbard Broil eggs were divided into two equal groups. Group 1 embryos (n:15) at Stage 8 (the four-somite stage) of development were explanted and grown for 18 hours in nutrient medium (thin albumin). Group 2 embryos (n:15) at Stage 8 (four-somite stage) of development were explanted and grown for 18 hours in nutrient medium containing 400 ?g/ml Diazepam. After the incubation period, 86.6% of the control embryos (Group 1) had intact neural tubes, and 80% of the Group 2 embryos showed neural tube defects. The results of this study suggest that Diazepam causes neural tube defects.Öğe Integrated miRNA profiling of estrogen receptor-positive breast cancer cell MCF-7(WILEY-BLACKWELL, 2015) Bozkurt, S. B.; Ozturk; Kocak, N.; Unlu, A.[Abstract not Available]Öğe Levels of arginine and its products in dialysis patients(VERDUCI PUBLISHER, 2014) Ugurcu, V.; Vatansev, H.; Unlu, A.; Sivrikaya, A.; Akyurek, F.; Ozturk, B.; Kiyici, A.OBJECTIVES: Chronic renal failure is among significant public health problems all over the world. Despite advances in diagnosis and treatment approaches, cardiovascular morbidity and mortality is still high in chronic renal failure patients on dialysis. The aim this study is to investigate the importance of arginine, asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in the pathophysiology of cardiovascular morbidity and mortality in patients with dialysis treatment program. PATIENTS AND METHODS: 53 patients with chronic renal failure receiving hemodialysis treatment and 34 healthy persons were participated to the study. Arginine and ADMA levels were measured by high-performance liquid chromatography (HPLC) fluorescence detector. NO levels were assessed by a colorimetric method. Albumin, urea, creatinine levels was performed using the spectrophotometric method. RESULTS: Arginine levels were similar in dialysis patients when compared to the control group. Similarly NO levels did not show any difference between patient group and the control group. ADMA levels were found to be significantly high in dialysis patients compared to the control group (p < 0.005). Arginine/ADMA ratio was lower in the patient group compared to the control group (p < 0.001). Dialysis patients who have diagnosed coronary artery disease had low levels of albumin and creatinine. Arginine levels, ADMA levels and NO levels did not show any difference in the patients with coronary artery disease or not (p > 0.05). Arginine levels were significantly higher in men compared to women. Pearson correlation analysis showed that there was a correlation between NO and arginine levels. Arginine and Arginine/ADMA showed a positive correlation while ADMA and arginine/ADMA levels showed a negative correlation. CONCLUSIONS: As a result, our data showed that ADMA clearance was impaired in hemodialysis patients. Increase in ADMA levels may play a role in atherosclerosis dependent morbidity and mortality.Öğe Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome(ELSEVIER SCIENCE BV, 2014) Yilmaz, S. A.; Kerimoglu, O. S.; Pekin, A. T.; Incesu, F.; Dogan, N. U.; Celik, C.; Unlu, A.Objective: The aim of the present study was to evaluate serum concentrations of metastin in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS). Study design: The study was a clinical study. Eighty-three women with PCOS and 66 body mass index (BMI) matched controls were divided into two groups, based on BMI: overweight and obese (BMI >= 25 kg/m(2)) and normal weight. (BMI < 25 kg/m(2)) Hirsutism scores, hormonal and metabolic profile as well as metastin levels were evaluated in each subject. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 AM, after an overnight fast. Circulating levels of LH, FSH, PRL, TSH, T, fT, DHEAS, 17-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, lipid profile and metastin were measured. Results: Metastin levels were significantly higher in the PCOS group compared to controls (2.02 ng/ml versus 1.16 ng/ml, p < 0.001). Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman-Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p < 0.05). When overweight or obese (BMI >= 25 kg/m(2)) and normal weight (BMI < 25 kg/m(2)) women with PCOS were compared to body mass index (BMI) matched controls, higher metastin levels were also found in PCOS groups (1.94 ng/ml versus 1.18 ng/ml, and 2.06 ng/ml versus 1.08 ng/ml, p < 0.05, respectively). Conclusions: These findings suggest that metastin levels were higher in women with PCOS as compared to controls regardless of BMI. Furthermore, metastin levels can be used as a specific marker for androgenic profile and this marker might play a role in the pathogenesis of PCOS. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Öğe Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome -- 2(OXFORD UNIV PRESS, 2014) Yilmaz, S. A.; Kerimoglu, O. Secilmis; Pekin, A.; Incesu, F.; Dogan, N. U.; Celik, C.; Unlu, A.[Abstract not Available]Öğe MMP-9 and TIMP-1 levels in the sputum of patients with chronic obstructive pulmonary disease and asthma(BLACKWELL PUBLISHING, 2006) Unlu, A.; Calikoglu, M.; Gun, D.; Ayaz, L.; Tamer, L.[Abstract not Available]Öğe Protective effects of grape seed proanthocyanidin extract in experimental obstructive jaundice(WILEY-BLACKWELL, 2013) Vatansev, H.; Savda, M.; Akyurek, F.; Cakir, M.; Ozturk, B.; Unlu, A.[Abstract not Available]Öğe Relationship Between ADMA Levels and chronic obstructive pulmonary disease progression(BLACKWELL PUBLISHING, 2007) Erdem, S.; Unlu, A.; Kanat, F.[Abstract not Available]Öğe Serum cytokine and chemokine profiles in patients with alopecia areata(TAYLOR & FRANCIS LTD, 2016) Bilgic, O.; Sivrikaya, A.; Unlu, A.; Altinyazar, H. C.Background: Most evidence supports the role of altered T cell-mediated immunity in the pathogenesis of alopecia areata (AA). Tough cytokines and chemokines play an important role in the immune process of AA, their expressions have been examined in limited studies. Objective: To determine serum cytokine levels of TNF-alpha, IL-6, and IL-23, and some of the Th1-(CXCL9), Th2-(CCL17), and Th17-associated (CCL20 and CCL27) chemokines in patients with AA. Methods: Forty patients with AA and 40 healthy controls were enrolled in the study. Serum concentrations of cytokines and chemokines were measured using enzyme-linked immunoassay techniques. Results: The mean serum levels of TNF-alpha, IL-6, IL-23, CXCL9, CCL17, CCL20, and CCL27 in AA patients were significantly higher than in the controls. However, with logistic regression analyses, only CCL17 and CCL27 levels showed a positive relationship, and IL-23 levels showed a negative relationship, with the presence of AA. Furthermore, serum CCL27 levels were positively correlated with AA severity. Conclusion: This study suggests that CCL17 and CCL27 may have an aggravating effect, whereas IL-23 may have a protective effect for the development of AA. Additionally, serum CCL27 levels may be useful as marker of disease severity.Öğe Vitamin D serum levels in children with allergic rhinitis(WILEY-BLACKWELL, 2015) Artac, H.; Ozdemir, H.; Unlu, A.; Bozkurt, M. K.; Bozkurt, B.[Abstract not Available]