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    Effectiveness of corticosteroids in otitis media with effusion: an experimental study
    (CAMBRIDGE UNIV PRESS, 2008) Yaman, H.; Ozturk, K.; Uyar, Y.; Gurbilek, M.
    Objective: The aim of the present study was to investigate the dose-related effectiveness of corticosteroids in the management of otitis media with effusion, by using the objective assessment techniques of tympanometry and cytokine measurement. Materials and methods: The eustachian tubes of 42 male rats were obstructed. Thirty-six subjects with effusion were randomly divided into three equal groups: controls; 0.5 mg/kg/day corticosteroid; and 1 mg/kg/day corticosteroid. Concentrations of interleukin-1 beta and tumour necrosis factor a in the middle-ear effusions were analysed using enzyme-linked immunosorbent assay. Results: An effusion occurred on the 14th post-operative day and was present on the 30th post-operative day in the control group. Otomicroscopic examination and tympanometric measurement showed an improvement in the intervention groups. There was a significant difference between both intervention groups and the control group for both interleukin-1 beta and tumour necrosis factor alpha concentrations (p < 0.01). However, there was no significant difference between the 0.5 mg/kg and the I mg/kg corticosteroid groups (p > 0.05). Conclusion: The study confirmed a short term beneficial effect of systemic steroids on resolution of otitis media with effusion in a rat model. Our results support the theory that corticosteroids significantly decrease concentrations of both interleukin-1 beta and tumour necrosis factor alpha. In our model, the 0.5 mg/kg corticosteroid dose was as effective as the 1 mg/kg corticosteroid dose. Further studies should be carried out to determine the optimal dose and duration of corticosteroids in the treatment of otitis media with effusion.
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    Transoral Approach to Pott's Disease of Cervical Spine
    (Turkish Neurosurgical Society, 1998) Özkal, E.; Üstün, M.E.; Uyar, Y.
    A rare case of tuberculosis of the upper cervical spine managed with transoral surgery is presented.
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    an Unusual Laryngeal Hamartoma - Lipofibroleiomyoma
    (DECKER PERIODICALS INC, 1993) Cenik, Z.; Uyar, Y.; Özer, B.; Güngör, S.; Bulun, E.
    [Abstract not Available]
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    An Unusual Laryngeal Hamartoma: Lipofibroleimyoma
    (1993) Cenik, Z.; Uyar, Y.; Özer, B.; Güngör, S.; Bulun, E.
    [Abstract not Available]
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    Vasoprotection by melatonin and quercetin in rats treated with cisplatin
    (NATL INST SCIENCE COMMUNICATION-NISCAIR, 2010) Atalik, K. E.; Keles, B.; Uyar, Y.; Dundar, M. A.; Oz, M.; Esen, H. H.
    Cisplatin-based chemotherapy has a variety of vascular side effects. The aim of the present study was to evaluate the beneficial effect of melatonin and cisplatin on the alterations in vascular reactivity and structure of cisplatin-treated rats. Phenylephrine (PHE) and KCI-caused concentration-dependent contractions of rat aorta. Pretreatment with cisplatin increased the sensitivity but not the max response to PHE and KCl. In rats treated with melatonin or quercetin before cisplatin, the EC(50) values, but not the maximal response to both agents were significantly higher than cisplatin-treated group. Compared to the control group, cisplatin-treatment significantly reduced the luminal area of the aorta. In melatonin and quercetin-treated aortas the luminal area values were significantly higher than cisplatin-treated group. The results demonstrate for the first time that melatonin and quercetin treatment may protect the aorta in cisplatin-based chemotherapy.