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    Comparison of Different Doses of Sufentanil for Control of Hemodynamic Response to Tracheal Intubation [trakeal Entübasyonda Oluşan Hemodinamik Yanitin Kontrolünde Sufentanilin Farkli Dozlarinin Karşilaştirilmasi]
    (2003) Tuncer S.; Reisli, Ruhiye; Yosunkaya, Alper; Tavlan, Aybars; Uzun S.; Ökesli S.
    In our study, we aimed to determine the most appropriate, sufficient, and safe dose of sufentanil in the hemodynamic response to laringoscopy and intubation. This study was performed on 45 ASA I-II physical status, without cardiovascular illness, normotansive patients planned for elective surgery. Patients were randomized into three equal groups. All patients received an intravenous midazolam premedication (0.03 mg kg-1. Ten minutes after, 0,1 ?g kg-1 sufentanil in Group I (GI), 0.15 ?g kg-1 sufentanil in Group II (GII) and 0.2 ?g kg-1 sufentanil in Group III (GIII) were administrated intravenously. About two minutes after, all patients received 2 mg kg-1 propofol and 1.5 mg k-1 succinylcholine. The patients were intubated under direct laringoscopy. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP) and heat rate (HR) were measured: at the beginning (10 min. qfter midazolam applicati-on) (tO), before propofol (tl), before laryngoscopy (t2), 1 and 3 minutes after the tracheal intubation (t3,t4). When the group parameter values were evaluated, it was observed that there was an significant increase in HR after the intubation (t3,t4) in G I (p>0.05). In G II SAP was significantly decrease after induction (t2) when compared with tO (p<0.05). All hemodyaamic parameter values (SAP, DAP, MAP, HR) were found significantly decrease at t2, t3, t4 in G III (p<0.05). When the groups were compared, there were no differences in all measurement times in the aspect of hemodynamic parameter values between G I and G IIH (p>0.05). SAP, MAP, HR values at t3 and SAP, DAP, MAP, HR at t4 were found significantly lower in G III than in G I (p<0.05) and HR values at t3, t4 were found significantly lower in G III than G II (p<0.05). Bradycardia occurred in seven patients in G III. As a result; We think that 0.15 ?g kg-1 sufentanil was safe and satisfactory to suppress the response after laryngoscopy and tracheal intubation in healthy normotensive patients without cardiovascular disease.