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Öğe Diastolic functions and myocardial performance index in obese patients with or without metabolic syndrome: A tissue Doppler study(2010) Koç F.; Tokaç M.; Kaya C.; Kayrak M.; Yazici M.; Karaba? T.; Vatankulu M.A.Objectives: This study was designed to evaluate left ventricular (LV) diastolic functions and myocardial performance index (MPI) in obese individuals with or without metabolic syndrome (MetS). Study design: The study included 44 obese subjects with MetS (16 men; 28 women; mean age 46±7 years) and 32 obese subjects without MetS (16 men, 16 women; mean age 43±9 years). Diagnosis of MetS was based on the ATP III criteria. Obesity was defined with a body mass index (BMI) of ?30 kg/m2. All the subjects underwent echocardiography and tissue Doppler imaging to determine LV diastolic functions and MPI. Clinical and echocardiographic characteristics of obese subjects were compared with those of a control group consisting of 21 healthy, nonobese individuals (10 men, 11 women; mean age 42±4 years). Results: Waist circumference, weight, and BMI were similar in the two obese groups. Control subjects and obese subjects without MetS had similar systolic and diastolic blood pressures, fasting blood glucose, triglyceride, and HDL cholesterol levels, but all these significantly differed in patients with MetS. Left ventricular mass, mass index, and diastolic parameters were similar in the two obese groups, but differed significantly from the controls (p<0.05). Body mass index was correlated with the LV mass (r=0.42, p=0.001) and mass index (r=0.33, p=0.001). Left ventricular MPI was similar in the two obese groups with (0.59±0.10) and without (0.59±0.11) MetS, but was higher compared to the control group (0.48±0.06, p<0.05). Left ventricular MPI was correlated with BMI, waist circumference, LV mass, and mass index (r=0.24, p=0.02; r=0.30, p=0.005; r=0.31, p=0.002; r=0.21, p=0.04, respectively). Conclusion: Our findings demonstrate that obesity with or without MetS affects LV MPI. In addition, LV MPI showed significant correlations with BMI, waist circumference, and LV mass.Öğe Isolated mitral valve prolapsus does not affect left ventricular function [İzole mitral kapak prolapsusu sol ventrikül fonksiyonunu etkilemez](2011) Demir K.; Koc F.; Can I.; Vatankulu M.A.; Yazici M.; Ülgen M.S.Aim: Idiopathic mitral valve prolapsus (MVP) is characterized by myxomatous degeneration of mitral valve. The most common determinant of cardiovascular mortality in patients with MVP is left ventricular (LV) dysfunction. Therefore we aimed to evaluate LV functions of cases with isolated MVP by tissue Doppler echocardiography (TDE). Method: Twenty five patients with MVP (mean age, 31±12 years) were enrolled the study as MVP group. Control group was consisted 20 age and sex matched patients (mean age, 34±9 years) were enrolled to this study. LV functions were detected by using conventional echocardiography and TDE. Myocardial peak systolic (Sm), early (Em) and late (Am) diastolic filling velocities, Em/Am, isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT) and ejection time (ET) were obtained in the basal segments of the inferior-septal and lateral wall. Myocardial performance index (MPI) was calculated. Result: Mild degree mitral regurgitation was present in 10 (40%) of patients with MVP, and moderate degree mitral regurgitation was present in 2 (8%) of patients. No difference was found between the two groups with regard to diastolic parameters. TDE-derivated MPI values were similar in all segments in two groups. There was significant difference between the two groups with regard to LV mean Sm and lateral wall Sm (11.6±2.8 vs. 9.4±1.0, p=0.001; 13.0±3.9 vs. 9.2±2.3, p=0.001 respectively). Conclusion: Isolated MVP without significant mitral regurgitation does not affect LV diastolic functions and MPI. However, Sm of late ral wall and LV mean was higher in patients with MVP than patients without MVP.Öğe Predictive value of lead aVR for lesions in the proximal portion of the left anterior descending coronary artery [Sol ön inen arter proksimal lezyonlarinin saptanmasinda aVR derivasyonunun de?eri](2006) Aygül N.; Özdemir K.; Tokaç M.; Aydin M.Ü.; Vatankulu M.A.Objectives: We aimed to investigate the predictive value of lead aVR in the evaluation of electrocardiograms (ECG) for lesions in the proximal portion of the left anterior descending (LAD) coronary artery. Study design: The study consisted of 361 patients (293 males, 68 females; mean age 58±10 years; range 24 to 84 years) with acute myocardial infarction (AMI), who presented with typical chest pain and ST elevation on ECG. All of the patients underwent coronary angiography (CAG) in order to identify the infarct-related artery (IRA) and its segments. Changes in the ST segment (i.e. elevation or depression) were evaluated in all leads including aVR. The patients were divided into two groups according to the ST elevation recorded in lead aVR, namely as positive (?0.5 mm) or negative (<0.5 mm). Results: The IRA segment was in the proximal LAD in 54% of the aVR positive group, and in 9% of the aVR negative group (p<0.001). Multiple vessel coronary artery disease was more common in the aVR positive group (p<0.001). There was a weak correlation between ST segment elevations in lead aVR and the Gensini score (r=0.21, p=0.002). In patients with anterior AMI, ST elevation in lead aVR predicted the IRA segment in the proximal LAD with 47% sensitivity, 91% specificity, 81% negative predictive value, 68% positive predictive value, and 78% diagnostic accuracy. Conclusion: In patients with anterior AMI, evaluation of aVR lead may be useful in localizing the IRA segment in the proximal LAD and predicting that an increased amount of myocardial tissue is at risk.