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    Benzimidazole schiff bases microwave assisted synthesis and the effect on leukemia cells with flow cytometry
    (EDITURA ACAD ROMANE, 2019) Celik, Seyma Celikbilek.; Vatansev, Husamettin.; Koc, Ziya Erdem.
    The present paper introduces a simple and efficient method for the synthesis of a 2-aryl-substituted benzimidazole by heterocyclization of 1,2-phenylenediamine and 5-aminoisophthalic acid in the presence of polyphosphoric acid as catalyst under solvent-less conditions, which produced good yield of corresponding benzimidazoles in a short reaction time. Two new bisbenzimidazoles and tetrakisbenzimidazole Schiff bases were synthesized by reaction between 3,5-di(1H-benzo[d]imidazol-2-yl)aniline (BIMA) and terephthalaldehyde or 4-formylbenzoic acid. The condensations proceed in short time to give products which, in certain instances, are not readily attainable by conventional condensation techniques. Due to its good performance, the microwave device used in household was preferred. The structures of the compounds were assigned by FT-IR, H-1 NMR, C-13 NMR and elemental analysis. The effects of benzimidazoles and Schiff bases on the cancerous cells have been known. Synthesized by bisbenzimidazole and bisbenzimidazole/tetrakisbenzimidazole-Schiff bases derivatives 3,5-di(1H-benzo[d]imidazol-2-yl)aniline (BIMA), N, N'-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(3,5-di(1H-benzo[d]imidazol-2-yl)aniline) (PM-BIMA), (E)-4-((3,5-di(1H-benzo[d]imidazol-2-yl)phenylimino)methyl)benzoic acid (BIM-PMBA) with flow cytometric analysis was performed, blastic cells containing 90%. We measured rates of cell death in cells blast on the matter.