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Öğe Amigdalin ile Zehirlenen Koyunlarda Siyanür ve Tiyosiyanatın Rumen Sıvısı ve Kandaki Bazı Toksikokinetik Parametrelerinin Araştırılması(Selçuk Üniversitesi, 1998) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Kaya, Sezai; Yarsan, Ender; Özaydın, SongülThis investigalion was carried out lo establish some toxicokineıic parameters of the eyanide in rumen liquor and eyanide and ıhiocyanate in blood ol ıhe sheep experimenıally poisoned with amygdalin. In this study , 20 sheep 40 - 50g weights were used. Amygdalin was givcn oraJly in doses ol 0.25, 0.5, 1 and 1.5 m9'k;g. The eyanide and Ihi· ocyanate levels in samples were determined. Then some toxicokinetic paramelers of the eyanide and Ihiocyanate like as the distribution half-life, the elimination half-life, mean residence times and area under Ihe curve (AUC) in rumen liquor and the blood samples laken at 0.5, 1, 2, 4, 8, 24, 48 and 72 Ih hours were eslablished. The distribution half· lifes ol eyanide levels in rumen liquor were respectively, 0.18iO.009, 0.14iO.Ol. 4.66iO.l1 and 4.82tO.17.hours; the elimination half-lifes were respectively, 17.22±O.66, 14.8O±O.43, 9.21iO.16 and 9.66iO.40 hours; AUe values ac· cording lo doses were respeclively, 30.68±O.65, 3O.04iO.24, 38.57iO.22 and 39.29±O.17 mg.hour/ml were observed. Besides mean residence times were respectively. 26.52±1.01, 23.66iO.33, 19.55iO.12 and 19.72±O.3S hours; the duration ol maximal eyanide concentration were respeclively, 2, " 8 and 8th hour; and the maximal eyanide levels ac· cording to were respeclively, 0.983. 1.025, 1.241 and 1.225 ?glml were determined. The distribution half-liles of blood eyanide levels were respectively, O. IStO.OS. 0.42±O.04, 1.4S±2.05 and 9.73±3.74 hours; the elimination hall·lifes were respectively, 59.48±4.40, 55.12±42.66, 70.77±4.10 and 48.05±19.27 hours; and AUe values according lo doses were respectively, ı8.45iO.85. 45.10±21.14, 27.45±2.02 and 2S.76±2.77 Jl9.hour/ml were established. Besides mean residence times ol eyanide levels in blood were respectively, B7.56t5.93, 86.94t54.02, 105.93t7.25 and 75.21±23.10 hours; the duraıion ol maximal concentration 1 hours; and the maximal blood levels according to doses were respeclively, 0.165, 0173, 0.166 and 0.210 mgfml were delermined. The distribution hatf-lifes of blood Ihiocyanate levels were respeclively, 2.05tl.45, O. t6iO.05. O. t7iO.04 and O.29±O.13 hours; the elimination half-liles were respectively, BB.93±2S.08, 73.21±19.44. BO.2BtıOAl and BO.81±15.26 hours; AUe values were respectively, B.60±6.42, 7.47±2.40, 7.14tl.02 and 10.67±3.55 Jlg.hour/ml; and mean residence times according to doses were respectively, 130.56t36.4B, 107.20±27.54. 1 t7.23t14.65 and 117.67±22.01 hours were calculated. Besicles, the duralion ol maximal eoneentralion " 2, 2 and 2 hours; and the maximal blood levels according to doses were respectively, 0.064,0.056, 0.066 and 0.056 mgml were determined.Öğe Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice(Selçuk Üniversitesi Veterinerlik Fakültesi, 2010) Yarsan, Ender; Altıntaş, Arif; Eşsiz, Dinç; Altıntaş, Levent; Pekcan, Mert; Çiftci, Gülay; İbrahim, Ishraga G.Amaç: Bu çalışmada, deneysel olarak cıva klorür ile böbrek hasarı oluşturulmuş farelerde 100 mg/kg dozda oral yolla uygulanan sülfametoksazolün farmakokinetiği değerlendirildi. Gereç ve Yöntem: Cıva klorür farelere 3 ve 6 mg/kg dozlarında verildi. Plazma sülfametaksazol konsantrasyonları spektrofotometre ile ölçüldü. Plazma konsantrasyon-zaman verileri dikkate alındığında ilacın 2 kompartmanlı açık modele uygun olduğu görüldü. Bulgular: Böbrek hasarı ile ilişkili olarak sülfametoksazolün emilim (AUC and t1/2a) ve eliminasyon (t1/2? and MRT) fazlarında önemli bulgular (p<0.05) gözlendi. Hasara bağlı olarak eğrinin altında kalan alan değeri düşerken, ortalama kalış zamanında artış tespit edildi (p<0.05). Öneri: Böbrek hasarlı hastalarda, sülfametoksazolün doz ve uygulama aralıklarının hasarın derecesine göre belirlenmesi çok önemlidirÖğe Pharmacokinetics of Enrofloxacin After Intravenous and Intramuscular Administration in Angora Goats(CANADIAN VET MED ASSOC, 2001) Elmas, Muammer; Traş, Bünyamin; Kaya, Sezai; Baş, Ahmet Levent; Yazar, Enver; Yarsan, EnderPharmacokinetics and bioavailability of enrofloxacin were determined after single intravenous (IV) and intramuscular (IM) administrations of 5 mg/kg body weight (BW) to 5 healthy adult Angora goats. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. Pharmacokinetics were best described by a 2-compartment open model. The elimination half-life and volume of distribution after IV and IM administrations were similar (t(1/2 beta), 4.0 to 4.7 h and V-d(ss),1.2 to 1.5 L/kg, respectively). Enrofloxacin was rapidly (t(1/2a), 0.25 h) and almost completely absorbed (F, 90%) after IM administration. Mean plasma concentrations of enrofloxacin at 24 h after IV and IM administration (0.07 and 0.09 mug/mL, respectively) were higher than the minimal inhibitory concentration (MIC) values for most pathogens. In conclusion, once-daily IV and IM administration of enrofloxacin (5 mg/kg BW) in Angora goats may be useful in treatment of infectious diseases caused by sensitive pathogens.Öğe Van Gölünde Avlanan İnci Kefali Örneklerinde Organik Klorlu İnsektisit Düzeyleri Üzerinde Araştırmalar(Selçuk Üniversitesi, 1996) Sağmanlıgil, Hülya; Bilgili, Ali; Yarsan, Ender; Türel, İdrisIn this research, total one hundred and sixty fishes (chalcalburnus tarichi) were used in 1994 and 1995 years. and heptachlore epoksite was only determined as organochlorine insecticides in these experiments. Heptachlore epoksite levels in fish meat were found as 0.0204 ppm. As a result, Van Lake and fish (chalcalburnus tarichi) was not contaminated with organochlorine insecticides, even if there are some low levels of heptachlore epoksite. This would suggest that contamination of Van Lake with organochlorine insecticides is not significant, therefore it is not life threatening.
