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Öğe Biocompatible thermoresponsive PEGMA nanoparticles crosslinked with cleavable disulfide based crosslinker for dual drug release(AMER CHEMICAL SOC, 2014) Ulasan, Mehmet; Yavuz, Emine; Bagriacik, Emin Umit; Cengeloglu, Yunus; Yavuz, Mustafa Selman[Abstract not Available]Öğe Biocompatible thermoresponsive PEGMA nanoparticles crosslinked with cleavable disulfide-based crosslinker for dual drug release(WILEY, 2015) Ulasan, Mehmet; Yavuz, Emine; Bagriacik, Emin Umit; Cengeloglu, Yunus; Yavuz, Mustafa SelmanSmart materials have been attracting much attention because of their stimuli responsive nature. We have synthesized biocompatible thermoresponsive crosslinked poly(ethylene glycol) methyl ether methacrylate (PEGMA)-co-vinyl pyrrolidone nanoparticles (PEGMA NPs) using disulfide-based crosslinker by surfactant-free emulsion polymerization method. Particle characterization studies were carried out by dynamic light scattering, and scanning electron microscopy. Polymerization kinetics, effect of crosslinker and initiator concentrations on both average hydrodynamic diameter and polydispersity index were investigated. Hydrodynamic diameters of thermoresponsive PEGMA NPs were decreased from 210 nm to 90 nm upon heating over the lowest critical solution temperature (LCST). Disulfide crosslinked PEGMA NPs were demonstrated as a dual delivery system. Rhodamine B, a model of small-sized drug molecule, and poly(ethylene glycol) (PEG)-alizarin yellow, a model of large drug molecule, were loaded into PEGMA NPs where LCST of these NPs was tuned to 37 degrees C, the body temperature. The rhodamine B was released from PEGMA NPs upon heating to 39 degrees C. Then, PEG-alizarin content was released by subsequent degradation of nanoparticles using dithiothreitol (DTT), which reduces disulfide bonds to thiols. Furthermore, cytotoxicity studies of PEGMA NPs were carried out in 3T3 cells, which resulted in no toxic effect on the cells. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 243-251, 2015.Öğe Evaluation of the interaction of gold nanocages with macrophages in raw 264.7 cell line-HBsAg model in vitro(ELSEVIER SCIENCE BV, 2017) Yavuz, Emine; Bagriacik, Emin Umit[Abstract not Available]Öğe Facile synthesis of boronic acid-functionalized nanocarriers for glucose-triggered caffeic acid release(SPRINGER, 2015) Ulasan, Mehmet; Yavuz, Emine; Cengeloglu, Yunus; Yavuz, Mustafa SelmanIn this study, boronic acid-functionalized methacrylate-based nanoparticles were synthesized via surfactant-free emulsion polymerization in one pot. Uniform (polydispersity index < 0.05) sub-100 nm nanoparticles were obtained. The changes of average hydrodynamic diameter and polydispersity index of nanoparticles against boronic acid content in total monomer and acetone percentage in the solvent mixture were investigated. Polymerization kinetics in terms of monomer conversion rate was monitored by gravimetric method. The nanoparticles were characterized by scanning electron microscopy and dynamic light scattering. The boron content in the nanoparticles was confirmed by electron-dispersive X-ray spectroscopy. Further, the nanoparticles were combined with caffeic acid. Caffeic acid carrying nanoparticles were titrated against glucose or fructose in which caffeic acid is released by the displacement reaction in a controlled manner. The displacement of caffeic acid and glucose was monitored by UV-visible spectral change. Furthermore, in vitro biocompatibility of nanoparticles was tested in NIH-3T3 cells, which resulted no significant toxicity effect on the cells.Öğe Novel method based on photothermal cleavage of thermolabile molecules on Au nanoparticles for controlled release(AMER CHEMICAL SOC, 2016) Goren, Ekrem; Cavusoglu, Halit; Yavuz, Emine; Usta, Hakan; Citir, Murat; Yavuz, Mustafa Selman[Abstract not Available]Öğe Novel photothermal-based release mechanism for controlled release on Au nanoparticles through light(AMER CHEMICAL SOC, 2015) Goren, Ekrem; Cavusoglu, Halit; Yavuz, Emine; Usta, Hakan; Yavuz, Mustafa Selman[Abstract not Available]Öğe One-pot synthesis of biocompatible boronic acid-functionalized poly(methyl methacrylate) nanoparticles at sub-100 nm scale for glucose sensing(SPRINGER, 2014) Sakalak, Huseyin; Ulasan, Mehmet; Yavuz, Emine; Camli, Sevket Tolga; Yavuz, Mustafa SelmanPoly(methyl methacrylate) nanoparticles containing 4-vinylphenyl boronic acid were synthesized in one pot by surfactant-free emulsion polymerization. The nanoparticles were characterized by scanning electron microscopy and dynamic light scattering. Boron content in the nanoparticles was confirmed by electron-dispersive X-ray spectroscopy. In polymerization process, several co-monomer ratios were studied in order to obtain optimum nanoparticle size. Average hydrodynamic diameter and polydispersity index of nanoparticles versus variation of acetone percentage in the solvent mixture and total monomer concentration were investigated. The effect of boronic acid concentration in the monomer mixture on nanoparticle size and size distribution was also reported. Without further functionalization to the nanoparticles, the catechol dye, alizarin red S, was bound to boronic acid-containing nanoparticles. These nanoparticles behave as a nanosensor by which glucose or fructose can be easily detected. Dye-containing nanoparticles were undertaken displacement reaction by glucose or fructose. The glucose or fructose content was also monitored by UV-Visible spectrophotometer. Furthermore, cytotoxicity studies of boronic acid-carrying poly(methyl methacrylate) nanoparticles were carried out in 3T3 cells, which showed no toxicity effect on the cells.Öğe Synthesis of biocompatible thermoresponsive PEGMA nanoparticles for dual release(AMER CHEMICAL SOC, 2015) Yavuz, Emine; Ulasan, Mehmet; Cavusoglu, Halit; Cengeloglu, Yunus; Yavuz, Mustafa Selman[Abstract not Available]
