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    Evaluation of Serum, Saliva and GCF Visfatin Levels in Chronic Periodontitis Patients with Uncontrolled /Controlled Type2 Diabetes Mellitus
    (Selçuk Üniversitesi, 2021) Yavuz, Mustafa Cihan; Çanakçı, Cenk Fatih
    Background: The aim of this study is to investigate visfatin levels in serum, saliva and GCF samples of non-diabetic CP patients, CP patients with t2DM and ut2DM, and to evaluate of the relationship with clinical and biochemical parameters of CP. Methods: Study protocol, 5 groups which each one were consisted of 15 subjects were planned: patients with both periodontal and systemic health (DM-P-); CP patients with systemic health (DM-P+), periodontally healthy patients with diabetes (DM+P-), patients with diabetes and CP (DM+P+), patients with uncontrolled diabetes and CP (uDM+P+). Serum, saliva and GCF samples were collected and levels of visfatin, TNF-? and IL-1? were determined by ELISA. Results: The highest levels of visfatin, TNF-? and IL-1? were seen in (uDM+P+) group (p>0.001). Significant positive correlations between GCF visfatin levels and GCF TNF-? and IL-1? levels were detected in (uDM+P+) group (p<0.001). Conclusion: Serum, saliva and GCF visfatin levels were highest in the uncontrolled diabetes group. Different studies are needed to clarify the effect of visfatin on glycemic control in patients with diabetes and its relationship with periodontal disease.