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    677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with Spina bifida occulta [Spina bifida okkultali hastalarda metilentetrahidrofolat redüktaz (MTHFR) geninin C677T ve A1298C polimorfizmlerinin analizi ve biyokimyasal parametrelerinin de?erlendirilmesi]
    (Turkish Neurosurgical Society, 2010) Eser B.; Cosar M.; Eser O.; Erdogan M.O.; Aslan A.; Yildiz H.; Boyaci G.
    Aim: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. Material and Methods: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. Results: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x2=3.325, P=0.068; x2=1.479, P=0.224; x2=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x2=8.477, P=0.004). The frequencies of the Aand C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x2=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). Conclusion: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.
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    Inhibitory effects of Aspirin on Azaserine initiated pancreatic carcinogenesis in rat
    (2008) Yildiz H.; Koc A.; Oztas H.; Yildiz D.
    The experiment was designed to investigate the effects of aspirin on the exocrine pancreas in azaserine-rat model. In azaserine treated rats and azaserine and aspirin treated rats were observed to include acidophillic atypical acinar cell foci (AACF). The observed reduction in stereological parameters in asazerine initiated aspirin treated group (AzAsp) in comparison with azaserine treated group (AzCt) suggest that azaserine induced pancreatic carcinogenesis may be inhibited by aspirin treatment in exocrine pancreas.