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    The effects of dimethyl sulfoxide on liver damage caused by ischemia-reperfusion
    (ELSEVIER SCIENCE INC, 2004) Sahin, M; Avsar, FM; Ozel, H; Topaloglu, S; Yilmaz, B; Pasaoglu, H; Avunduk, MC
    Introduction. The aim of this study was to investigate the effects of dimethyl sulfoxide on liver damage caused by ischemia-reperfusion after portal vein clamping. Material and methods. Forty New Zealand rabbits were divided into three groups with the portal veins of all the rabbits except the sham group clamped for 30 minutes: group I, sham procedure; group II, control group; and group III, 500 mg/kg DMSO. The drug was administered IM in the left inguinal region 30 minutes before the operation. Blood samples (5 mL) were taken from the animals at 15, 30, and 45 minutes. At the end of the experiment 1 g of liver tissue samples were obtained. Malondialdhyde (MDA), nitric oxide (NO), AST, ALT, and LDH plasma levels were measured in the blood samples. Liver tissue samples stained with hematoxylin eosin were examined under light microscopy for histopathological changes. Finding. The liver enzymes in both clamping groups increased significantly compared with the sham group (P < .01). Enzyme levels of the DMSO group decreased significantly compared to the control clamping group (P < .05). Similar to the enzyme changes, MDA and NO levels increased in the portal vein clamping versus the sham group and decreased in the drug-administered group versus the control clamped group (P < .03). The severity of histopathological changes was less in the DMSO group than in the clamped controls. Conclusion. DMSO decreased the severity of liver damage after portal vein clamping.
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    Histological examination of various tissues in rats with hypothyroidism induced by propylthiouracil or thyroidectomy
    (LIPPINCOTT WILLIAMS & WILKINS, 1999) Mogulkoc, R; Canpolat, L; Baltaci, AK; Yilmaz, B; Kelestimur, H
    Despite the common use of propylthiouracil (PTU) to induce hypothyroidism, it causes degeneration of the thyroid gland, kidney and anterior pituitary tissue. The aim of our study was to determine changes in the liver, thyroid gland, kidney and anterior pituitary from male rats treated with PTU (10 mg/kg/day; for 2 weeks) and in thyroidectomy-induced hypothyroid male rats. Histological examination was performed by light microscopy. Total T3 and T4 levels were determined by radioimmunassay. In both PTU-treated and thyroidectomized groups, plasma T3 and T4 levels were significantly lower than those in the control group. No abnormal changes were observed in the liver tis sue of the hypothyroid rats. There were significant decreases in the epithelial magnitude of degenerated follicular cells in the thyroid tissues of the PTU-treated animals. Furthermore, these were seen in the lumen, which did not contain colloid. There was mononuclear cell infiltration and haemorrhage in the kidney cortex and medulla in both the thyroidectomized and PTU groups. The anterior pituitary in the thyroidectomized and PTU-treated rats showed a diffused hyperplasia. The tissue was locally haemorrhagic, and basophilic cells were frequently localized at the side of the haemorrhage. These findings show that both PTU and thyroidectomy-induced hypothyroidism causes changes in the histology of the kidney, thyroid gland and anterior pituitary. Med Sci Res 27:801-805 (C) 1999 Lippincott Williams & Wilkins.