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Öğe Anaphylaxis in pediatric patients: a multi-center, retrospective, case study(WILEY, 2009) Orhan, F.; Boz, Bingol A.; Yilmaz, O.; Reisli, I; Cakir, M.; Karakas, T.; Yuksel, H.[Abstract not Available]Öğe Anaphylaxis in Turkish children: a multi-centre, retrospective, case study(WILEY, 2011) Orhan, F.; Canitez, Y.; Bakirtas, A.; Yilmaz, O.; Boz, A. B.; Can, D.; Kuyucu, S.Background Anaphylaxis is a serious and potentially lethal systemic reaction affecting more than one organ or system. Objective We aimed to describe the demographic characteristics, clinical features, causes, settings, and administered therapy in Turkish children. Methods This retrospective, case note study included all children referred to the outpatient clinics of the Pediatric Allergy Departments of the participating study centres from 1 July 1999 to 30 June 2009 for investigation of anaphylaxis or who were seen by us at the moment of the reaction during the same period and who met the clinical criteria of anaphylaxis. Results Two hundred and twenty-four cases of anaphylaxis were reported in 137 children (88 boys, P = 0.0001). The mean +/- SD age at the referral was 7.7 +/- 4.2 years (range: 4 months-17 years). Ninety-eight episodes (43.8%) occurred at home. The symptoms were cutaneous in 222 (99.1%) episodes, respiratory in 217 (96.9%), neuro-psychiatric in 118 (52.7%), cardiovascular in 92 (41.1%), and gastrointestinal in 88 (39.3%). Biphasic reaction was reported in seven episodes (3.1%, 95% CI: 1.5-6.3). Death occurred in one case (0.4%, 95% CI: 0.08-2.4). Treatment was available in 158 episodes (70.5%). Of them, 148 (93.7%) received antihistamines, 132 (83.5%) corticosteroids, 51 (32.3%) epinephrine, and 17 (10.8%) beta-2-mimetics. The causative agents were foods in 86 (38.4%) episodes, hymenoptera venom in 84 (37.5%), drugs and medications in 47 (21.0%), and latex in 5 (2.2%). In two episodes (0.9%), the causative agent was unidentified. Allergy to the trigger was known prior to anaphylaxis in 116 (51.8%) episodes. An epinephrine autoinjector had been prescribed for 70 children (51.1%). Conclusions and Clinical Relevance Anaphylaxis was seen significantly more in boys. Most of the reactions occurred at home. Foods were the most frequent cause. Epinephrine, the first-line treatment of anaphylaxis, was administered in only a third of the children.Öğe A comparison of liquid-based cytology with conventional cytology(ELSEVIER IRELAND LTD, 2008) Celik, C.; Gezginc, K.; Toy, H.; Findik, S.; Yilmaz, O.Objective: To evaluate the 2 methods of cytologic screening to detect abnormalities of the cervical epithelium. Methods: This study with 3 groups of women was performed at Selcuk University Meram Medical School between January 2004 and March 2006. In one group (paired sample for specimen collection) women were screened with conventional cytology; in another group (paired sample for specimen collection) they were screened with liquid-based cytology; and in the third group (split sample for specimen collection) they were screened by both methods. Results: The rate of unsatisfactory results was lower in the liquid-based than in the conventional cytology group (6.1% vs. 2.6%; P < 0.05). More smears containing atypical squamous cells of undetermined significance were detected by the liquid-based method, but the difference was not statistically significant. Also, no statistically significant differences between liquid-based and conventional cytology were observed in the detection of other epithelial abnormalities (P > 0.05). Conclusion: The liquid-based and conventional cytology methods were found to be equivalent in the detection of cervical epithelial abnormalities. (c) 2007 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.Öğe EFFECT OF ESTRUS SYNCHRONIZATION PROTOCOLS INCLUDING PGF(2 alpha) AND GnRH ON FERTILITY PARAMETERS IN HAIR GOATS DURING BREEDING SEASON(PAKISTAN AGRICULTURAL SCIENTISTS FORUM, 2017) Cinar, M.; Ceyhan, A.; Yilmaz, O.; Erdem, H.The present study was performed to determine the effect of PGF(2 alpha) and GnRH injections in different time intervals on fertility in Hair goats during breeding season. Totally, 80 primiparous Hair goats were divided into four groups (n=20 in each) according to the body condition scores of the animals. The animals in groups were treated as follows; first group (Ovsynch), GnRH on day 0, PGF(2 alpha) on day 7 and GnRH on day 9; second group (2PG-G), PGF(2 alpha) on day 0, PGF(2 alpha) on day 7 and GnRH on day 9; third group (PG-G), PGF(2 alpha) on day 7 and GnRH on day 9; fourth group (G), GnRH on day 9. Bucks were included into the groups on day 10-14 and insemination was performed during standing heat. Blood samples were collected to determine possible embryonic losses on day 21 for further analysis of serum progesterone concentrations. Transabdominal ultrasonography was performed to detect pregnancy on day 40-45. It was determined that in Ovsynch, 2PG-G, PG-G and G groups, estrous rate was 100%, 95%, 95% and 85%; pregnancy rate was 85%, 95%, 95% and 85%; kidding rate was 100%, 78.9%, 94.7% and 88.2%; twinning rate was 41.2%, 40%, 22.2%, 20%; litter size was 1.41, 1.40, 1.22, 1.20, respectively. However, these parameters did not show any significant difference between groups (P> 0.05). In conclusion, it is suggested that all treatment procedures may be used for estrous synchronization in Hair goats during breeding season due to the satisfactory results.Öğe Effects of PCR-confirmed subclinical paratuberculosis on retinol and beta-carotene levels in dairy cattle(UNIV AUSTRAL CHILE, FAC CIENCIAS VETERINARIAS, 2009) Civelek, T.; Celik, H. A.; Ozenc, E.; Avci, G.; Kav, K.; Cingi, C. C.; Yilmaz, O.In the present study, the effects of IS900 PCR-confirmed subclinical paratuberculosis on serum beta-carotene and retinol concentrations in dairy cattle were investigated. A total of 30 multiparous, clinically normal, paratuberculosis non-vaccinated Holstein dairy cows, ages 3 to 9 years old were tested. Fifteen of the 30 cows were diagnosed as having subclinical paratuberculosis by IS900 PCR on faecal samples (Group 1). The remaining 15 cows, negative to three independent tests for paratuberculosis, were classified as the healthy control group (Group 2). Serum retinol and beta-carotene levels were analyzed by colorimetric assays on serum samples from all 30 cows. There were no differences regarding the serum retinol and beta-carotene concentrations between cows with and without paratuberculosis.Öğe THE EFFECTS OF RALOXIFENE ON OSTEOCALCIN, AS A BONE TURNOVER MARKER IN ORCHIECTOMIZED RATS(EDITURA ACAD ROMANE, 2014) Saklamaz, A.; Uyulgan, B.; Sevin, G.; Kebapcilar, L.; Yilmaz, O.; Cimrin, D.; Kumanlioglu, K.Background. The aim of the present study was to measure the effects of raloxifene on bone metabolism and strength in orchiectomized male rats. Materials/Methods. Forty-three 4-month-old Wistar albino male rats were used and divided into 3 groups as orchiectomy (ORCX; n=23), sham (n=15), and control (n=5). Raloxifene (10 mg/kg/day) and methylcellulose (0.5 mL/day, as a vehicle treatment) treatments were initiated 2 months after ORCX for 2 months, then the rats were sacrificed. The left femur and fourth lumbar vertebrae (LV4) were measured to assess the effects of the orchiectomy and the raloxifene treatment and maintenance regimens. Bone strength was assessed using a compression test for the vertebrae and a three-point bending test for the femurs (N/mm). Results. Raloxifene increased femoral and vertebral bone strength in osteoporotic rats, but this increase was not statistically significant. Bone strength was found to be 267.44 +/- 18.03 in the femurs of the ORCX-raloxifene group and 246.32 +/- 49.37 in the femurs of the ORCX-C group (p>0.05). Vertebral bone strength was 147.78 +/- 09.51 in the ORCX-raloxifene group and 114.61 +/- 05.93 in ORCX-C group (p=0.488). Raloxifene also increased the femoral and vertebral bone density compared with the control group, but the change was not significant. While raloxifene significantly decreased the serum osteocalcin levels (p=0.007), it did not decrease the carboxyterminal cross-linking telopeptide of bone collagen (CTX) levels significantly (p=0.066). Conclusions. Raloxifene caused a statistically significant decrease in serum osteocalcin levels and a non-significant reduction in NTX levels in orchiectomized rats.Öğe The "extreme" errors in inhaler device use: data from the INTEDA-1 study(WILEY-BLACKWELL, 2011) Caliskaner, Z.; Ozturk, C.; Pekcan, S.; Yilmaz, O.; Ozturk, S.; Ceylan, E.; Can, C.[Abstract not Available]Öğe Influence of education on primary care physicians' knowledge on childhood allergy as a systemic disease and the atopic march(ELSEVIER DOYMA SL, 2011) Yilmaz, O.; Reisli, I.; Tahan, F.; Orhan, F.; Boz, A. B.; Yuksel, H.Background: There are many educational events for physicians in different countries covering one or some of the allergic diseases. Most of these educational events have been reported to improve care by the physicians. The aim of this study was to determine the baseline knowledge of general practitioners (GP) regarding the systemic nature of childhood allergy and atopic march, and to assess the influence of an educational event on this baseline knowledge. Methods: Two hundred and two GPs from five different cities in Turkey who attended education seminars were enrolled. All GPs were received the questionnaire both before and after the seminar. The questionnaire had statements about the systemic nature of childhood allergies and the atopic march, and GPs were asked to mark their degree of agreement as (completely true, partially true, wrong). Results: Mean age of GPs was 38.6 +/- 6.0 years. Mean duration after graduation from medical faculty was 13.9 +/- 6.5 years. There was significant improvement in answers after education. The statement "Frequency of allergic rhinitis and asthma is not as high as expected in children with atopic dermatitis" was regarded "wrong" by 60.9% but increased to 94.3% after the education (p < 0.001). Systemic nature of allergy was approved by 72.8%, which increased to 99% after the education (p < 0.001). Adrenalin as first line treatment in anaphylaxis treatment was appreciated by a higher number of GPs with the education (p<0.001). Conclusion: Many GPs lack updated information about the systemic nature of paediatric allergic diseases and a single educational event may improve their knowledge significantly. (C) 2010 SEICAR Published by Elsevier Espana, S.L. All rights reserved.Öğe Influence of postgraduate education on the knowledge of primary care physicians on childhood allergy and the allergic march as a systemic disease(WILEY-BLACKWELL PUBLISHING, INC, 2009) Yilmaz, O.; Reisli, I; Tahan, F.; Orhan, F.; Boz, Bingol A.; Yuksel, H.[Abstract not Available]Öğe Physicians' knowledge of and opinions about inhaler treatments in asthma and COPD: the INTEDA-1 study(WILEY-BLACKWELL, 2011) Caliskaner, Z.; Ozturk, C.; Pekcan, S.; Yilmaz, O.; Ozturk, S.; Ceylan, E.; Can, C.[Abstract not Available]
