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Öğe Calixarenes in organo and biomimetic catalysis(Springer, 2016) Yilmaz M.; Sayin S.Organocatalysis and biocatalysis have emerged as new and powerful tools especially in asymmetric synthesis. This survey is focused to have an overview of calixarene based organo- and biomimetic catalysis. Calix[n]arenes constitute a fascinating class of macrocycles that have found a broad spectrum of applications in supramolecular chemistry and molecular recognition. The scope of the present review is to provide an overview of applications of calixarene-based materials in asymmetric catalysis and biomimetic catalysis. © Springer International Publishing Switzerland 2016.Öğe Effects of some humidity and IBA hormone dose applicatıons on rooting of M9 apple clonal rootstock softwood top cuttings(Academic Journals, 2010) Ersoy N.; Kalyoncu I.H.; Aydin M.; Yilmaz M.In this study, softwood cuttings were taken from M9 dwarf apple rootstocks in early June. Different indole-3-butyric acid (IBA) concentrations [0 (control), 500, 1500, 2500 and 3500 ppm], different air humidity levels (85 - 90%, 95-100%) and rooting media of perlite effects on rooting capability and root formation of M9 apple rootstock cuttings were examined. All the cuttings remained alive. The highest ratio of cutting callus formation was found in control group (58%) in 95 - 100% humidity level and 2500 ppm IBA hormone dose application in 85 - 90% humidity level. The highest rooting ratio was obtained from control group (46%) in 95 - 100% humidity level; the lowest one was 3500 ppm IBA dose application (17%) in 85 - 90% relative humidity level. The highest rooting surface lenght was found in 1500 ppm hormone dose (0.53 cm) in 95 - 100% and 2500 ppm IBA dose application (0.42 cm) in 85 - 90% humidity level. With respect to root numbers, the highest value was from 1500 ppm IBA application (1.29 number/cutting) in 95 -100% relative humidity, and 500 and 2500 ppm IBA doses (1.04 number/cutting) in 85 - 90% relative humidity level. The longest root was obtained from control group (2.03 cm) in 95 - 100% humidity level and 500 ppm IBA hormone dose (1.80 cm) in 85 - 90% humidity level. The shortest root was obtained from 1500 ppm IBA hormone application (0.79 cm) and control group (0.88 cm) in 95 - 100% humidity level. The highest root branching value was obtained from 1500 ppm hormone dose application (0.88 number/cutting) in 95 - 100% humidity level. © 2010 Academic Journals.Öğe Inclusion of Quercetin in Gold Nanoparticles Decorated with Supramolecular Hosts Amplifies Its Tumor Targeting Properties(American Chemical Society, 2019) Yilmaz M.; Karanastasis A.A.; Chatziathanasiadou M.V.; Oguz M.; Kougioumtzi A.; Clemente N.; Kellici T.F.Despite the anticancer potential of natural products (NPs), their limited bioavailability necessitates laborious derivatization or covalent conjugation to delivery vehicles. To unleash their potential, we developed a nanohybrid delivery platform with a noncovalently tunable surface. Initially, the active compound was encapsulated in a macrocycle, p-sulfonatocalix[4]arene, enabling a 62â000-fold aqueous solubility amplification as also a 2.9-fold enhancement in its cytotoxicity with respect to the parent compound in SW-620 colon cancer cells. A pH stimuli responsive behavior was recorded for this formulate, where a programmable release of quercetin from the macrocycle was monitored in an acidic environment. Then, a nanoparticle gold core was decorated with calixarene hosts to accommodate noncovalently NPs. The loaded nanocarrier with the NP quercetin dramatically enhanced the cytotoxicity (>50-fold) of the parent NP in colon cancer and altered its cell membrane transport mode. In vivo experiments in a mouse 4T1 tumor model showed a reduction of tumor volume in mice treated with quercetin-loaded nanoparticles without apparent toxic effects. Further analysis of the tumor-derived RNA highlighted that treatment with quercetin-loaded nanoparticles altered the expression of 27 genes related to apoptosis. © 2019 American Chemical Society.Öğe Kinetics of mercury (II) transport through a bulk liquid membrane using macrocyclic compound as carrier(2006) Koyuncu H.; Ersoz M.; Yilmaz M.[Abstract not Available]Öğe A novel colorimetric/fluorometric dual-channel sensor based on phenolphthalein and Bodipy for Sn (II) and Al (III) ions in half-aqueous medium and its applications in bioimaging(Elsevier Ltd, 2020) Gul A.; Oguz M.; Kursunlu A.N.; Yilmaz M.The aim of this study was to develop a new colorimetric and fluorometric chemosensor for Sn (II) & Al(III) detection in half aqueous medium. A new probe containing Bodipys, appended on phenolphthalein (PP-B) was synthesized with multi-step reactions. The structure of intermediate products and target compound was characterized with spectroscopic techniques. The absorption and emission properties of the synthesized PP-B probe were investigated in detail and it was deduced that PP-B probe possesses a specifically real-time, fluorometric and colorimetric response to Sn(II) and Al(III) in H2O/acetone (v/v: 1:1). The selectivity of the probe was checked in the presence of competing metal ions [Al(III), Zn(II), Cu(II), Cd(II), Fe(II), Sn(II), Hg(II), Co(II), Pb(II), Ga(III), Cr(III)]. It was found that there was a marginal difference in fluorescence response of PP-B towards Sn (II) and Al (III) in the presence of competing metal ions. Under the optimized conditions, 1:2 (ligand:metal) stoichiometries were obtained by Job's plot for Sn(II) and Al(III) complexes, respectively. Cell viability study was carried out to check the applicability of probe in human cancer cell lines. Fluorescence images of the probe (PP-B) in human lung cancer cell lines with XTT (sodium 3?-[1-[(phenylamino)-carbony]-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene-sulfonic acid hydrate) test to detect the presence of Sn (II) and Al (III) were acquired by using a confocal laser scanning microscope. © 2020 Elsevier LtdÖğe Organic based magnetic nanoparticles-polymers and various calixarene based magnetic nanoparticles(Nova Science Publishers, Inc., 2012) Yilmaz M.; Sayin S.Magnetic nanoparticles have been attracting much interest in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying as well as in the fields of separation science. Although, the most suitable matrix will always depend on the future application of the material, organic polymers have been often a suitable choice owing to their high process ability and versatility. The in situ precipitation of the magnetic particles in a polymeric matrix is an excellent method to control the mean size and size dispersion of a nanoparticles population. The organic based magnetic nanoparticles have been recently used many applications such as separation chemistry which is depend on removal of heavy metal ion and toxic oxyanions from aqueous solute, quantitative pharmacokinetic analysis of the uptake of nanoparticles in the vasculature, brain, and glioma and tumor uptake etc. This review describes synthesis of organic based-iron oxide magnetic nanoparticles with coated silica based materials or some organic compounds and the preparation of different substituted calixarene-based magnetic nanoparticles. It has been also discussed about their characterization. Besides, we have described exhaustive some of the possible applications of both organic-based magnetic nanoparticles and various calixarene based magnetic nanoparticles in the different fields, especially in the separation science. Finally, we have addressed some relevant findings on the importance of having well-defined synthetic routes to produce materials. © 2012 by Nova Science Publishers, Inc. All rights reserved.Öğe Surface coating of magnetite nanoparticles with fluorescence derivative for the detection of mercury in water environments(Elsevier B.V., 2020) Oguz M.; Bhatti A.A.; Yilmaz M.In this study, we report synthesis of new fluorescent compound integrated with Fe3O4 nanoparticles for the detection of mercury ion (Hg2+) in aqueous environment. Fluorescent compound synthesized by reacting dansyl chloride with isonipecotic acid in one simple step reaction. The synthesized compound, dansyl-isonipecotic acid (DIA) was coated on Fe3O4 nanoparticles. Fe3O4-DIA nanoparticles have average size of 20 nm and pore size 0.3 nm as confirmed from Transmission Electron Microscope (TEM). Fluorescence study shows the quenching in intensity after addition of Hg2+ ion in Fe3O4-DIA nanoparticles solution, which is due to energy transfer from excited state of ligand to low-lying empty d-orbital of Hg2+. The quenching effect was also confirmed from confocal microscope images of Fe3O4-DIA nanoparticles. © 2020 Elsevier B.V.