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  • Küçük Resim
    Öğe
    Effect of Pedunculated Seromuscular Flap on Bursting Strength of Intestinal Anastomosis After Corticosteroid Treatment
    (Lippincott Williams & Wilkins, 2000) Yol, Serdar; Yol, Sinan; Tavlı, Şakir; Şahin, Mustafa; Özer, Şükrü
    PURPOSE: This study was designed to investigate the protective effect of a pedunculated seromuscular flap on intestinal anastomosis after corticosteroid treatment. METHODS: Forty male Sprague-Dawley rats were divided into four groups, and all animals underwent intestinal anastomosis. Two groups, with or without seromuscular flap wrapping, received 5 mg cortisone acetate, and two groups received placebo (saline) preoperatively for 16 days. Anastomotic strength was defined as bursting pressure (in millimeters of mercury). The pedunculated seromuscular flap was prepared from a segment of intestine next to the anastomosis. intestinal bursting strength at the anastomotic site was measured at Postoperative Day 8. RESULTS: The anastomotic bursting strength was significantly lower in the steroid groups at Postoperative Day 8 (P < 0.01). The pedunculated seromuscular flap increased the strength of the anastomosis both in the steroid and control groups (P < 0.05). CONCLUSION: The adverse effect of corticosteroids on intestinal anastomoses may be prevented by a pedunculated seromuscular flap.
  • Küçük Resim
    Öğe
    Ratlarda Kronik Perioperatif Steroid ve İmuran Kullanımının Kolon Anastamoz İyileşmesi ve Patlama Basıncına Etkileri
    (1999) Yol, Sinan; Yol, Serdar; Beck, David E.
    The alm of present study was to compare the effects of long term chronic preoperative steroids and azathioprine on colonic anastomotic healing and tissue strength. One hundred male Sprague-Dawley rats weighing 260-330 grams were divided into four groups, each of which had 25 animals. Group I received two placebo tablets. Group II received a time release drug pellet(200 mg cortisone acetate in a 60 day release form) and a placebo pellet placed in the subcutaneous tissue of the posterior neck for an average daily dose of 3.3 mg cortisone. Group III received a time release drug pellet (50 mg azathioprine in a 60 day release form) and a placebo pellet for an average daily dose of 0.83 mg azathioprine. Group IV received two time release drug pellets(200 mg cortisone acetate and 50 mg azathioprine each in a 60 a day release form). After 6 weeks all animals underwent division and anastomosis of their midtransverse colon. One and two weeks after anastomosis, colonic bursting pressures were determined at the anastomotic site and in the normal left colon by measuring intraluminal pressures at which leakage/rupture occurred. Blood cortisol levels and histopathologic changes were also compared. There was no significant difference in bursting pressures(anastomosis and normal left colon) between treated and control animals at 7 and 14 days. Bursting pressure at the anastomotic site was significantly lower then left colonic site at 7 and 14 days (p<0.05). The increase in pressure at the anastomotic site by 14 days was statistically significant for each group (p<0.05). There was no significant difference at left colon for first and second week. In conclusion, bursting pressure of the colonic anastomosis was not affected by long term administration of cortisone acetate and azathioprine at seventh and 14(th) days of anastomosis in this rat model.