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Öğe The effects of chrysin in an experimental model of acute pancreatitis(Edizioni Luigi Pozzi, 2020) Alptekin H.; Calisir A.; Özturk B.; Ugurlu C.; Yormaz S.; Ece I.PURPOSE: This experimental study was conducted to evaluate the possible effects of orally administered chrysin on acute pancreatitis. MATERIAL AND METHOD: Twenty four rats were procured. The animals were randomly divided into four groups. In Group I, only vehicle solution (5% dimethylsulfoksid) was administered, and in Group II, chrysin dissolved in the vehicle solution was administered for six days. In Group III and Group IV cerulein was administered to induce acute pancreatitis. In Group III, only vehicle solution was administered, and in Group IV, chrysin dissolved in the vehicle solution was administered orally for six days. Blood samples were analyzed and the pancreatic tissue specimens were evaluated for histopathological examination. RESULTS: Group III and Group IV, exhibited markedly higher levels of serum WBC, amylase, and lipase, compared with Groups I and II. In the pancreatitis induced groups, CRP and TOS values were found to be significantly higher. In Group II and Group IV, TAS values were significantly higher. The highest calculated OSI values were observed in Group III. Group IV OSI values were significantly lower than those in Group III and even in Group I. Noticeable histopathological changes were identified in the pancreatitis induced Groups III and IV. Compared with Group III, the extent and severity of pancreatic injuries were markedly lower in Group IV. CONCLUSION: Chrysin application reduced oxidative stress and histopathological parameters. The present study shows that chrysin can be used to treat pancreatic diseases. © 2020, Edizioni Luigi Pozzi. All rights reserved.Öğe A New Approach to the Complicated Liver Hydatid Cyst--Laparoscopic Roux-en-Y Cystojejunostomy(2015) Yilmaz H.; Sahin M.; Ece I.; Yormaz S.; Alptekin H.Surgery is still the gold standard in the treatment of hepatic hydatid disease. One of the major problems associated with hydatid cyst surgery is biliary fistula. In this report, we aimed to describe a laparoscopic internal drainage method for the treatment of complicated hepatic hydatid cyst in order to prevent long-term biliary fistulas. A 44-year-old female was referred to our clinic with the complaints of flank pain. On computerized tomography of the abdomen, an 8-cm hydatid cyst was detected on the right lob of the liver. Laparoscopic exploration demonstrated a cysto-biliary communication, and laparoscopic cystojejunostomy was performed to prevent long-term bile leakage. The patient was discharged on postoperative day 5 without any problems. In 45th days, nearly complete obliteration of the cavity was observed. Laparoscopic cystojejunostomy can be an effective and safe surgical approach for the treatment of complicated hepatic hydatid cysts.Öğe Treatment of staple line leaks after laparoscopic sleeve gastrectomy with self-expandable metalic stents [Laparoskopik sleeve gastrektomi sonrası stapler hattı kaçaklarının genişleyebilen metalik stentler ile tedavisi](Turkiye Klinikleri, 2016) Ece İ.; Yilmaz H.; Alptekin H.; Acar F.; Yormaz S.; Çolak B.; Şahin M.Objective: Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric procedure on weight loss and obesity-related comorbidities. The most important complication of LSG is the staple line leaks (SLL). This study aims to report the SLL rate and its management with self-expandable stent in a series of 422 LSGs. Material and Methods: A total of 422 patients underwent LSG from January 2010 to June 2015. A retrospective study was performed to the patients who were diagnosed as staple line leak at department of obesity surgery of a university hospital. The gastric resection was started from the antrum with a distance of 4-6 cm to the pilorus, by a 60mm staples. A 36F bougie was used to calibrate the gastric tube. The staple line was routinely reinforced with running sutures. The patients who developed SLL were treated endoscopically with self-expandable metalic stent (SEMS) placement. Results: The mean age of patients were 41.8 (29-55) years, and female/male ratio was 7/5. Mean body mass index of 44.1 kg/m2 in patients, one of the cases has a gastric banding history. SLL rate was 12/422 (2.8%). Leak area was near the gastroesophageal junction in all cases. SLL was treated with self-expandable metalic stents. All patients were received medical support, including parenteral nutrition and antibiotics. The stent treatment modalities were successful in all cases. Conclusion: SLL was the most common complication of LSG accounting for half of the overall complications. Self-expandable stents combined with antibiotics and parenteral nutrition are effective for SLL and should be proposed as first-line treatment in stable patients. © 2016 by Türkiye Klinikleri.