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Öğe A case with distal trisomy 10q24(SPRINGER, 2005) Tasdemir, P.; Zamani, A. G.; Demirel, S. S.; Acar, A.[Abstract not Available]Öğe Determination of whole genome expression differences in larynx cancers and clinical significance(NATURE PUBLISHING GROUP, 2018) Goktas, E.; Yildirim, M. S.; Ozturk, K.; Zamani, A. G.[Abstract not Available]Öğe Effect of Mobile Phone Station on Micronucleus Frequency and Chromosomal Aberrations in Human Blood Cells(MEDECINE ET HYGIENE, 2010) Yıldırım, M. S.; Yıldırım, A.; Zamani, A. G.; Okudan, N.Effect of mobile phone station on micronucleus frequency and chromosomal aberrations in human blood cells: The use of mobile telephones has rapidly increased worldwide as well as the number of mobile phone base stations that lead to rise low level radiofrequency emissions which may in turn have possible harm for human health. The national radiation protection board has published the known effects of radio waves exposure on humans living close to mobile phone base stations. However, several studies have claimed that the base station has detrimental effects on different tissues. In this study, we aimed to evaluate the effects of mobile phone base stations on the micronucleus (MN) frequency and chromosomal aberrations on blood in people who were living around mobile phone base stations and healthy controls. Frequency of MN and chromosomal aberrations in study and control groups was 8.96 +/- 3.51 and 6.97 +/- 1.52 (p: 0.16); 0.36 +/- 0.31 and 0.75 +/- 0.61 (p: 0.07), respectively. Our results show that there was not a significant difference of MN frequency and chromosomal aberrations between the two study groups. The results claim that cellular phones and their base stations do not produce important carcinogenic changes.Öğe The effects of smoking on aneuploidy and aneuploidy frequency in infertile males: a five-colour FISH study(SPRINGER, 2005) Durakbasi-Dursun, H. G.; Zamani, A. G.; Kutlu, R.; Gorkemli, H.; Bahce, M.; Acar, A.[Abstract not Available]Öğe Evaluation of death pathway genes FAS and FASL polymorphisms in chronic HBV infection(WILEY-BLACKWELL, 2013) Zamani, A. G.; Barlas, I. O.; Durakbasi-Dursun, G.; Ural, O.; Erdal, E.; Yildirim, M. S.This study was designed to determine the possible asssociation between selected FAS and FASLG polymorphisms and Hepatitis B virus (HBV) infection. FAS-670 G/A, FAS-1377 G/A, FASLG-844 T/C and FASLGIVS2nt-124 A/G polymorphisms were genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). A total of age and sex matched 108 controls and a hundred chronic HBV patients were recruited to conduct a case-control study. FAS-670 polymorphism was associated with chronic HBV infection (P=0.03) FAS-1377 GG, GA and AA genotypes among the cases (90%, 5% and 5%, respectively) were significantly different from those among the controls (68%, 31.5% and 5.6%; P=0.00). FASLG-844 allele distribution was similar between the groups (P=0.17) but TC genotype (67.3%) was frequent in chronic HBV patients, while CC genotype was found significantly higher (29.6%) in controls. No association between FASLGIVS2nt-124 polymorphism and chronic HBV infection could be identified (P=0.55). FAS-670 polymorphism is associated with chronic HBV infection, while FASLGIVS2nt-124 A/G polymorphism is not. The FAS-1377G/A and FASLG-844 T/C genotypes are likely to play a substantial role in HBV infection. Further studies evaluating polymorphisms in other genes related with apoptosis are needed to elucidate the role of genetic variation in HBV infection.Öğe Evaluation of smoking genotoxicity in Turkish young adults(2011) Zamani, A. G.; Durakbaşı, Hatice Gül Dursun; Demirel, S.; Acar, A.BACKGROUND: For the past few decades, it has been widely known in developed countries that tobacco is dangerous, but it is still insufficiently realized how big these dangers really are. AIMS: To determine and evaluate micronuclei (MN) frequencies of young smokers and nonsmokers in three different tissues (peripheric blood lymphoctes, buccal mucosa, and exfoliative urothelial cells) at the same time. MATERIALS AND METHODS: MN assay was performed on buccal mucosa, urothelial cells, and peripheric blood lymphocyte samples obtained from 15 healthy male smokers (>5 pack-years) and 15 healthy male nonsmoker controls who had not been exposed to any known genotoxic agent. STATISTICAL ANALYSIS USED: The statistical differences between smoker and nonsmoker groups were calculated by using student t test. The differences between smoker-group tissues were compared by ANOVA. RESULTS: It was found that MN frequency (mean value standard deviation) in oral mucosa cells from smokers and controls were 1.20 ± 0.22% and 0.26 ± 0.10%; in urothelial exfoliative cells, 1.29 ± 0.28% and 0.12 ± 0.08%; in peripheric blood lymphocytes, 1.53 ± 0.23% and 0.38 ± 0.12%, respectively. The mean MN frequencies in buccal mucosa, urothelial exfoliative cells, and peripheric blood lymphocytes were significantly higher in smokers than in those of controls (P<0.05). All tissues were affected from smoking, but the most destructive effect was seen in urothelial cells of smokers (P<0.05). CONCLUSIONS: Our data showed that cigarette smoke is a DNA damage causitive agent on exfoliative buccal mucosa and urothelial cells and peripheric blood lymphocytes of young smokers, but it has most destructive effect on urothelial cells.Öğe A new heritable fragile site at 15q13 in a three generation family(SPRINGER, 2005) Zamani, A. G.; Durakbasi-Dursun, H. G.; Acar, A.[Abstract not Available]Öğe A new heritable fragile site at 15q13 in a three-generation family(KARGER, 2007) Zamani, A. G.; Durakbasi-Dursun, H. G.; Acar, A.Here, we describe a family ascertained through recurrent spontaneous abortions in which a new heritable fragile site located at 15q13 is segregating. The fragile site was present in nine members of a three-generation family and expressed spontaneously in a high proportion of the metaphases varying from 88 to 95% under standard culture conditions in all the carriers. This didn't change under folate deficiency. Copyright (c) 2007 S. Karger AG, Basel.Öğe Warburg Micro Syndrome in Two Children From a Highly Inbred Turkish Family(MEDECINE ET HYGIENE, 2012) Yıldırım, M. S.; Zamani, A. G.; Bozkurt, B.Warburg micro syndrome in two children from a highly inbred Turkish family: Warburg Micro syndrome (WMS) was first reported by Warburg in 1993. The cardinal features are microcephaly, microphthalmia, congenital cataract and intellectual disability. We report on two children from a highly inbred family with microcephaly, congenital cataract, optic atrophy, hypotonia and severe psychomotor retardation. This phenotype is similar to other reported rare entities and especially to the family reported by Warburg. Four other children in the same family may also have been affected. In this report, the symptoms and features of our cases are compared with the Warburg Micro syndrome patients in literature.
