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Öğe Emergency medical technician professional competence perception scale: Validity and reliability study(Selçuk Üniversitesi, 2024) Hakyemez, Fatma; Katı, CelalThe objective of this study was to develop a reliable and valid instrument to assess the professional competence of emergency medical technicians. The research sampling consists of 820 students who were in their last year of the First and Emergency Aid Program. The tools utilized for data collection included a Demographic Information Form, the Emergency Medical Technician Professional Competence Perception Scale (EMT-PCPS), and the Self-Efficacy-Competence Scale. To test the validity of the measuring tool’s structure, exploratory factor analysis (EFA), item analysis and confirmatory factor analysis (CFA) were used. Cronbach Alpha coefficients and testretest results have been examined for reliability testing. According to the validity test results, the 4-factor structure of EMT-PCPS explains 70.45% of the total variance. According to the reliability analysis results, the item-total test correlation values were greater than .30, the Cronbach’s alpha coefficient was .97, and the correlation values between test-retest scores were medium to good (p<.01). The research found that the EMT-PCPS is a valid and reliable measuring instrument for analyzing the professional competence perception levels of Emergency Medical Technicians who are candidates to keep working in the profession.Öğe Investigation of the frequency and characteristic features of de novo mutations in clinical exome sequence trio samples(Selçuk Üniversitesi, 2024) Koçak, Nadir; Torabi, Ali; Şanlıtürk, Batuhan; Bağcı, Özkan; Marzioğlu Özdemir, Ebru; Çora, TülünAdvanced genome sequencing technologies have provided us with the opportunity to deeply understand the mechanisms underlying conditions associated with the genome. There has been significant interest recently in understanding the characteristics of de novo mutations, which are genetic changes that arise in reproductive cells and are not present in parents, as well as the mechanisms involved in their occurrence. These mutations can be transmitted to subsequent generations and have the potential to influence genetic diversity and susceptibility to diseases, making this topic important. Due to limited studies in this area, the formation mechanisms and characteristic features of such mutations have not yet been fully understood. In this study, we aimed to conduct a comprehensive analysis of de novo mutations in families undergoing trio clinical exome sequencing analysis. The objectives of the study were to investigate the relationship between parental ages and the frequency of de novo mutations, the distribution, prevalence, relationships, and molecular characteristics of de novo mutations. A total of 69 families who underwent Trio Clinical Exome Sequencing (CES) analysis at the Department of Medical Genetics, Faculty of Medicine, Selçuk University, between January 1, 2017, and December 31, 2023, were included in the study. DNA samples extracted from peripheral venous blood of individuals were sequenced using the Roche CES kit and DNBSEQ-G400™ sequencing device, and a total of 3892 genes were analyzed using the Seq Platform. Correlation analysis revealed no significant relationship between parental age and the number of de novo mutations, and regression analysis showed that age was not a significant parameter in determining the number of de novo mutations. After analysis, 407 de novo variants were identified, with the majority being variants of unknown significance (55.28%). When examining the base change profile, the most common changes were found to be C -> G, G -> A, A -> G. The most commonly mutated genes were found to be DSPP, HPS4, VCL, and BMP4 genes.Öğe Correlation between outpatient preliminary diagnosis of venous insufficiency and venous doppler ultrasound findings: A retrospective cohort study(Selçuk Üniversitesi, 2024) Orhan, AtillaBackground: This retrospective cohort study delves into the correlation between outpatient preliminary diagnoses of venous insufficiency and venous Doppler ultrasound findings. Methods: Conducted at our hospital from 01.0102018 to 31.12.2018, the study scrutinized patient records to gauge the concordance between clinical diagnoses and Doppler ultrasound results. Results: Among the 92 patients included in the analysis, Doppler ultrasound confirmed venous insufficiency diagnoses in 46.74% of cases. More than half of the patients who were initially suspected to have venous insufficiency had normal radiological findings. This suggests that during outpatient treatments, physical examination may not be given enough consideration due to the high number of patients. Moreover, it can be a time-consuming and labor-intensive process. Furthermore, our findings suggest that there is a strong correlation between venous reflux in a lower extremity vein and its impact on adjacent veins. Conclusions: The study highlights the crucial importance of Doppler ultrasonography in improving diagnostic precision, particularly for patients who have not undergone a thorough physical examination in the outpatient clinic. The study also finds that changes in flow due to venous insufficiency primarily affect adjacent veins.Öğe Preoperative Hepatitis B seroprevalence and AntiHBs levels in children consulted for dental procedures under anaesthesia(Selçuk Üniversitesi, 2024) Sert, Sadiye; Kaya, FatmaBackground/Aims: Hepatitis B virus infection continues to be a major global and national public health concern. The aim of this study was to examine the seroprevalence of hepatitis B virus in children who were consulted to child health and diseases before dental intervention and to share our findings with the healthcare personnel involved in this subject. Methods: A total of 932 children 533 of whom (57.2%) were boys and 399 (42.8%) were girls were enrolled in the study. In the blood samples taken; hepatitis B virus tests were studied with the Enzyme Linked Immunosorbent Assay method. The results of blood samples and demographic data of the patients were evaluated. Results: HBsAg positivity was not found in any of the patients (0%). AntiHBs seropositivity was found in 73.8% of the whole patient population. No statistically significant difference was detected when comparing the anti-HBs levels based on gender. The average age of children with antiHBs seropositivity was statistically significantly lower than that of those with antiHBs seronegativity. The median anti-HBS antibody levels were significantly higher in the group of children under 5 years old than in the other two age groups older than five years old in our study. When investigating the association between the level of antiHBs and age, a weak negative correlation was determined. Conclusion: Our study showed that the antiHBs seropositivity is higher in Konya province compared to previous studies. It suggests that the national vaccination program has a positive impact on antiHBs seroprevalence. Our study revealed that children under the age of five displayed the highest levels of anti-HBs seropositivity, while the anti-HBs levels diminished with advancing age.Öğe Maternal and umbilical cord heat-shock protein 70 levels in patients with Gestational Diabetes Mellitus(Selçuk Üniversitesi, 2024) Bertizlioğlu, Mete; Yılmaz, Setenay Arzu; Kebabcılar, Ayşegül; Pekin, Aybike Tazegül; Seçilmiş, Özlem; Gencoğlu Bakbak, Berat Berrin; Abuşoğlu, Sedat; Çelik, Çetin; Ünlü, Ali; Doğan, Nasuh Utku; Aktaş, GörkemObjectives: The objective of this investigation is to ascertain whether there is an increase in the levels of heat shock protein 70 (HSP70), a signal for cellular stress, in the maternal bloodstream and umbilical cord of pregnancies affected by gestational diabetes mellitus (GDM). Additionally, the aim is to explore whether variations in the concentrations of Hsp70 in umbilical cord serum can be indicative of the likelihood of early term delivery (between 37 0/7 and 38 6/7 weeks of gestation) in women diagnosed with GDM compared to the control group. Methods: In this case-control study, 62 individuals diagnosed with gestational diabetes mellitus (GDM) comprised the GDM group while 22 non-diabetic, healthy women scheduled for cesarean section formed the control group. Our analysis encompassed the examination of Hsp70 serum levels in both maternal pregnancies and umbilical cord sera, alongside an evaluation of various biochemical and anthropometric markers. Additionally, the study explored the occurrence of early term delivery among all subjects. Results: The concentration of Hsp70 in the maternal serum exhibited a notable increase among individuals diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnant women. Similarly, the levels of Hsp70 in the umbilical cord were elevated in GDM patients although the difference did not reach the commonly accepted significance threshold. Notably, cord Hsp70 levels displayed a statistically significant negative correlation with the time of delivery in women with GDM. This inverse relationship with the time of delivery was also observed in the overall study group, indicating a potential association between cord Hsp70 levels and the timing of delivery. Conclusion: Maternal Hsp70 was significantly higher in patients with GDM. The obtained results seem to indicate that elevated umbilical cord Hsp70 values may potentially be used as indicators of risk factor for preterm delivery in pregnancies.Öğe Psychosocial effect of COVID-19 phobia in health workers in the pandemic service and intensive care(Selçuk Üniversitesi, 2024) Ünal, Gonca Ayşe; Kenar, Ayşe Nur İnci; Bülbül, MerveObjective: It was aimed to evaluate the phobia levels of COVID-19 (Coronavirus disease 2019) in medical staff working in the pandemic ward and intensive care unit and to examine its relationship with psychosocial impact levels. Material and Method: The study included 100 people working in the pandemic ward and intensive care units in the first year of the pandemic. Sociodemographic data Form, COVID-19 Pandemic Psychosocial Impact Scale (CPPIS) and COVID-19 Phobia Scale (CPS) were administered to all participants. Results: The mean age of the participants was 32.5±7.4 years and 74% of them were women. Of these, 29% were doctors, 52% were nurses, 19% were allied health personnel and 66% worked in the service, 29% in the intensive care unit and 5% in both. There was very strong correlation between the CPS and the CPPIS total score, the death anxiety and anxious thoughts subscale scores. A strong positive correlation was found between the CPS and CPPIS subscales scores including close relationships, functionality and somatic symptoms. There was significant positive correlation between CPS and CPPIS scores and the duration of working in the pandemic service and intensive care unit. Conclusion: It was considered that as choranophobia increased among medical staffs working in the pandemic service, their psychosocial effects also increased. It has been thought that reducing the working time in the service and/or intensive care unit during the pandemic, performing shortterm rotations, might reduce the level of psychosocial impact and even be protective in terms of mental health of medical staff.Öğe Comparison of radiofrequency ablation and steroid injection in the treatment of plantar fasciitis; short and medium term results(Selçuk Üniversitesi, 2024) Sert, Mahmut; Yurteri, AhmetObjective: Plantar fasciitis, commonly encountered in orthopaedic practice, can impede daily life activities and result in a loss of workforce. This study aimed to assess the short- and mediumterm outcomes of radiofrequency ablation (RFA) and steroid injection treatments in patients with plantar fasciitis who did not benefit from conservative therapies, using pain and function scores. Materials and Methods: Between July 01, 2021, and January 01, 2023, patients diagnosed with plantar fasciitis at Hakkari State Hospital were examined. Those not responding to conservative treatments and underwent RFA or steroid injection were divided into two groups. Demographic information, Visual Analog Scale (VAS), and American Orthopedic Foot and Ankle Society (AOFAS) scores were analyzed, and both groups were compared. Results: The 6th-month post-treatment scores of 69 patients meeting inclusion criteria were examined (35 with RFA, 34 with steroid injections). Patients underwent RFA had a mean age of 43.89 ± 10.31 years, with 25 females and 10 males. Those receiving steroid injections had a mean age of 48.74 ± 5.00 years, with 23 females and 11 males. No significant difference was observed when comparing pre-intervention VAS and AOFAS values for both groups (p=0.469, p=0.244). There was no significant difference in the first-month VAS and AOFAS values between the two groups (p=0.764, p=0.466, respectively). However, a significant difference was observed in the post-6-month VAS and AOFAS values (p=0.001, p=0.001). Significant differences were found between VAS and AOFAS values in patients receiving RFA at both pre-intervention and 6 months (p=0.001, p=0.001). No significant difference was observed in pre-intervention and 6-month VAS and AOFAS values in steroid injections (p=0.512, p=0.844, respectively). No complications were observed in both groups during the follow-up period. Conclusion: In patients who did not benefit from conservative treatment, radiofrequency ablation has been found an effective, safe, and minimally invasive method for reducing pain severity in the short to medium term and improving daily activities.Öğe Evaluation of the presentation of newly Diagnosed Type 1 Diabetes Mellitus in children during and after the COVID-19 pandemic(Selçuk Üniversitesi, 2024) Özgüç Çömlek, Fatma; Özdemir, Semine DilekBackground: The COVID-19 pandemic has been a global health problem with high morbidity and mortality. In this study, it was aimed to compare the clinical and laboratory findings of patients diagnosed with type 1 diabetes mellitus (T1D) during the pandemic and after the pandemic. Method: This is a 30-month-single-center, cross-sectional study. The time between October 2020 and December 2021 was defined as the pandemic period, and between January 2022 and March 2023 as the post-pandemic period. During these periods, clinical and laboratory parameters of pediatric patients diagnosed with T1D were compared at the time of admission. Results: While 87 patients were diagnosed during the pandemic period, 86 patients were diagnosed during the post-pandemic period. The rate of male patients diagnosed during the pandemic period was significantly higher (56%, 36%, respectively, p=0.007). Anti-islet Cell antibody (ICA) positivity was statistically significantly higher in those diagnosed during the pandemic period. (52.6%, 18.6%, respectively, p<0.001). There was no difference between the groups in terms of hemoglobin A1C, thyroid autoantibodies and tissue transglutaminase antibodies (p>0.05). C peptide levels were significantly lower in those diagnosed during the pandemic period (0.39±0.4, 0.63±0.6, respectively, p=0.021). Admissions with severe acidosis were more common during the pandemic than those admitted after the pandemic (29.9%, 16.3%, respectively, p=0.151). Conclusion: The numbers of children with T1D newly diagnosed in a secondary health center were similar during and after the pandemic. In the pandemic period, admissions with autoantibody positivity, low C-peptide and severe acidosis were more common.Öğe Evaluation of Skin Prick Test results performed for the diagnosis of inhaled allergens in Konya(Selçuk Üniversitesi, 2024) Ürün Ünal, Bahar; Can Erçin, Ayşe; Külhaş Çelik, İlknur; Artaç, HasibeObjective: We aimed to determine the distribution of inhaled allergens by evaluating the results of skin prick tests performed on patients with allergic complaints in Konya. Material and Methods: The study included 2351 patients aged 2-18 years who underwent skin prick tests for the diagnosis of inhaled allergens at the Selçuk University Medical Faculty Pediatric Allergy and Immunology Outpatient Clinic between June 1, 2022, and May 31, 2023. The demographic characteristics and skin prick test results of 696 patients with sensitivity to at least one inhaled allergen were retrospectively evaluated. Results: Sensitivity to at least one inhaled allergen was detected in 696 (29.6%) of 2351 patients who underwent skin prick testing for allergic symptoms. The mean age of patients with inhaled allergen sensitivity was 10.37 ± 4.14 years. 278 (39.9%) of the patients were girls, and 418 (60.1%) were boys. Considering the distribution of inhaled allergens detected by the skin prick test, the most frequent allergens were pollen allergens (78.2%), cat epithelium (38.8%), and dog epithelium (33.8%). The most common allergens detected in girls were pollen allergens (77.3%), cat epithelium (38.1%) and house dust mites (37.1%). The most common allergens detected in males were pollen allergens (78.7%), cat epithelium (39.2%), and dog epithelium (34.7%). Sensitivity to house dust mites was more prevalent in girls than boys. Sensitivity to pollen allergens was most frequently detected in all seasons. Significant differences were detected between house dust mites, pollen allergens, rye, and cat epithelium sensitivities according to seasons. Conclusion: Our study shows the distribution of inhaled allergens in Konya province. Therefore, we assume that it can contribute to the implementation of environmental measures that can be taken to protect against allergens and, thus, to the treatment of patients.Öğe Comparison of diagnostic performance of PI-RADS V2 and V2.1 and interobserver agreement in both versions(Selçuk Üniversitesi, 2024) Baytok, Ahmet; Koplay, Mustafa; Özer, Halil; Topaloğlu, Ömer Faruk; Kaynar, Mehmet; Göktaş, Serdar; Batur, Ali FurkanObjective: To compare the diagnostic performance for the detection of clinically significant prostate cancers and interobserver agreement between PI-RADS v2 and v2.1 Material and Method: The mpMRI images of 258 patients and 394 nodüles included in this retrospective study were obtained on 3T MR and evaluated by two radiologists according to PIRADS v2 and v2.1. Sensitivity and specificity between v2 and v2.1 were compared. Detection rates for clinically significant prostate cancers were evaluated. Interobserver agreement was evaluated using κ statistics. Results: PI-RADS v2.1 and v2 had higher sensitivity and lower specificity (100%, 52.38%) in the peripheral zone, and showed higher sensitivity and specificity (92.86%, 98.79%) in the transition zone for category ≥4 lesions to estimate csPCa, but no remarkable difference was found between the two versions. Interobserver agreement was statistically significant and very weak in the transition zone (κ=0.383, κ=0.279, respectively), very strong in the peripheral zone (κ=0.869) according to both classifications and they were similar. Conclusion: The diagnostic performance of PI-RADS v2 and v2.1 were found similar in the determination of clinically significant cancers and all cancers in both zones. The clinically significant cancer detection rate in category 2+1 lesions in the transition zone was higher than in category 2 lesions but it was not statistically significant. Interobserver agreement was low in the transition zone and very strong in the peripheral zone in both versions.Öğe The relationship between acute phase reactants levels at the time of admission and comorbid conditions with mortality in patients diagnosed with Covid-19(Selçuk Üniversitesi, 2024) Erinmez, Muhammet Ali; Köylü, Ramazan; Köylü, ÖznurBackground/aims: The covid-19 pandemic, which is a global problem, is still one of the most important health problems today. Treatment and vaccine studies are as important in predicting prognosis and mortality as early diagnosis and prevention of the disease, which continues unabated. In this study, it was aimed to evaluate the success of laboratory values, comorbid conditions and intensive care scoring at the time of first admission in predicting the mortality of patients admitted to intensive care with the diagnosis of Covid-19. Methods: The study was conducted in a tertiary adult emergency deparment. The study included 106 patients who were admitted to the emergency department and subsequently admitted to intensive care, had a positive Covid-19 polymerase chain reaction(PCR) test and met the inclusion criteria. Results: The average age of 106 patients included in the study was 71.85. Of these patients, 65.09 % were male and 24.1% were female. While 29 of the patients were survivors, 77 were deceased. In deceased patients; procalcitonin, lactate, leukocyte, neutrophil, urea, creatine, asti crpi ferritin, d-dimer values were found higher than the other group. Lymphocyte, lymphocyte percentage and pH values were significantly low. Sequential Organ Failure Score(SOFA) and Acute Physiology and Chronic Health Evaluation(APACHE) 2 scores were higher in deceased patients. Conclusion: Ferritin, lactate, urea and pH values, comorbid conditions, Sequantial Organ Failure Score and Acute Sphysiology and Chronic Health Assessment 2 can be used to predict mortality in covid-19 disease.Öğe Does burnout due to COVID-19 affect resilience? The sample of doctors in Turkiye(Selçuk Üniversitesi, 2024) Yiğitbaş, Çağla; Bulut, Aliye; Bulut, AzizObjective: The consequences of the coronavirus pandemic on doctors are significant. This study was conducted to determine the resilience or burnout status of physicians, the characteristics that make a difference on them and whether burnout predicts resilience. Method: The study was conducted with a quantitative method and a general survey model. 246 physicians were reached in the descriptive cross-sectional study. The volunteers with ethical permission were ensured to be able to answer all questions before collecting the data obtained with the principle of voluntary participation. Results: Age range, income perception, whether they like their profession or not, and whether they are satisfied with the unit they work in are the variables that make a difference in the levels of resilience and burnout of physicians. Self-efficacy, family and social network, coping, and adaptation scores of the physicians in the study were above average in terms of their resilience. Personal achievement and satisfaction with the unit they work predict resilience. Conclusion: In order to increase the resilience of doctors in extraordinary conditions such as pandemics, conditions such as ensuring that they are satisfied with their workplace and supporting their personal success should be created.Öğe The Relationship between uric acid/HDL ratio and monocyte/HDL ratio and glycemic control in male type 2 diabetic patients(Selçuk Üniversitesi, 2024) Öztürk, Semra Özkan; Ecin, Seval MüzeyyenBackground: Type 2 diabetes mellitus (T2DM) is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. The aim of this study is to investigate the relationship between blood glucose regulation and two different parameters: uric acid/HDL ratio (UHR) and monocyte/HDL ratio (MHR) in male subjects with type 2 diabetes. Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose (HbA1c levels exceeding 7, n=83) and the group with good glycemic control (HbA1c levels at or below 7, n=83). Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein (HDL), uric acid, low-density lipoprotein (LDL), neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acid/HDL ratio, body mass index and monocyte/HDL ratio were compared. Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group (P<0.001). In contrast, diabetic patients had lower HDL levels than healthy subjects (P=0.002). Serum uric acid levels were lower in the blood glucose unregulated group than in the blood glucose well-regulated group and healthy subjects (P<0.001). UHR was lower in the blood glucose unregulated group compared to the blood glucose well-regulated group and healthy subjects (P=0.003). White blood cell, neutrophil and lymphocyte counts were higher in diabetic patients than in the healthy group (P<0.001, P<0.001, P=0.002). Platelet count and MHR values were higher in the blood glucose-unregulated group compared to the blood glucose-regulated group and healthy subjects (P=0.007). Conclusion: Increased MHR and decreased UHR levels are associated with uncontrolled blood glucose regulation in male patients with type 2 diabetes.Öğe Attitudes of teachers towards ındividuals with mental health problems and affecting factors(Selçuk Üniversitesi, 2024) Demirbaş, Nur; İlhan, Ömer Adil; Karaoğlu, Nazan; Tosun, MuhammetAim: Teachers are in a good position to provide first aid to students with mental health problems. The aim of the study is to determine the attitudes of teachers towards individuals with mental health problems and the factors affecting them. Materials-methods: The research, which is a cross-sectional descriptive study, was conducted with teachers reached online via social media. Sociodemographic information form, Hospital Anxiety-Depression Scale and Community Attitudes towards the Mentally Illness Scale were applied to the teachers via Google forms. The data were evaluated with the SPSS 20 statistical program. A p value of <0.05 was considered statistically significant. Results: In this study, 477 teachers were participated. Psychological Counseling and Guidance (PCG) teachers' “mental health ideology” (19.24±3.99) and “goodwill” scores (18.07±3.16) were found to be lower than the scores of preschool and classroom teachers (p=0.001; p=0.014). The goodwill score of male teachers (20.27±3.66) was found to be higher than which of female teachers (19.38±3.19). The risk of anxiety was found in 17.00% of the teachers participating in the study and the risk of depression was in 27.62%. The goodwill approach of teachers with anxiety risk to those with mental problems was lower than those without anxiety risk (p=0.003). Conclusion: It is noteworthy that the attitudes of teachers towards individuals with mental health problems are at a moderate level, and that the attitudes of teachers who are especially young, women and who frequently encounter these patients are negatively affected.Öğe Degenerated (ancient) schwannomas: Unraveling unusual locations and treatment management(Selçuk Üniversitesi, 2024) Günerhan, Göksal; Çağıl, Emin; Şenol, Yiğit Can; Dağlar, Zeynep; Işıtan, Egemen; Tunç, Bekir; Güreşçi, Servet; Dalgıç, AliIntroduction: Schwannomas, originating from Schwann cells in peripheral nerve sheaths, exhibit diverse clinical manifestations and unpredictable behavior. Among them, ancient schwannomas, with distinctive degenerative features, present in atypical locations and pose diagnostic challenges. This study explores their unique characteristics and implications for diagnosis and management. Material and Methods: The study was designed as a retrospective analysis of 7 adult patients aged ≥18 years diagnosed with paraspinal, presacral, sacral, or para-aortic tumors, and all histologically confirmed as ancient schwannomas. Data for analysis were collected from patients treated and followed up at Ankara City Hospital between April 2017 and December 2022. Ethical approval and informed consent were obtained before inclusion in the study. Results: The most common symptoms included the presence of a local lump (71,4%) and localized or radiating pain (57,1%). Notably, one patient (14,2%) was incidentally diagnosed during the evaluation process. Surgical intervention played a crucial role in the management of these tumors, with 71,4% of patients underwent complete resection while 28,5% underwent subtotal resection. Tumor recurrence occurred in 42,8% of cases, prompting the administration of radiotherapy as part of the treatment strategy. Imaging findings, particularly on MRI, played a crucial role in the accurate identification of ancient schwannomas. These tumors displayed isointensity on T1 weighted images and heterogeneous hyperintensity on T2-weighted images, along with distinctive heterogeneous contrast enhancement. Conclusion: Ancient schwannomas exhibit unique histological features and distinctive MRI characteristics, differentiating them from other nerve sheath tumors. Early diagnosis and complete surgical resection offer favorable outcomes. Awareness of this entity is essential for managing peripheral nerve sheath tumors effectively.Öğe Resistance rates of mycobacterium tuberculosis complex ısolates to first-line anti-tuberculosis drugs: A 5-year retrospective study(Selçuk Üniversitesi, 2024) Ibnouf, Sondos A. A.; Taşbent, Fatma EsenkayaBackground/Aim: Tuberculosis (TB) remains a major global health problem with a high morbidity and mortality rate, approximately a quarter of the population is infected with tuberculosis. Drug susceptibility testing is an essential tool to identify and manage drug-resistant tuberculosis. This study was conducted to evaluate the drug susceptibility pattern of Mycobacterium tuberculosis complex strains isolated from a university hospital. Methods: A total of 10900 samples sent to the microbiology laboratory with the suspicion of tuberculosis clinically between January 2018 and January 2022 were analyzed retrospectively. The automated BACTEC MGIT 960 (Becton Dickinson, USA) was used for sample culture and susceptibility testing. The obtained data were statistically analyzed with the Statistical Package for Social Sciences (SPSS version 20). Results: Out of the 154 isolated positive samples, males and females constituted equal parts of the study population (50%). The majority of tuberculosis cases were in the age group of 56–75 years (42.2%). Pulmonary tuberculosis was detected in 139 (90.3%) of the patients while extrapulmonary TB cases were observed in 15 (9.7%) patients. As a result of susceptibility studies on positive samples, isoniazid resistance was 5.2%; streptomycin resistance 1.3%; ethambutol resistance was detected at a rate of 0.6% while no rifampicin resistant sample was found. Both streptomycin and isoniazid resistance were seen together in 1.3% of the samples. Conclusion: A similar resistance pattern of the first-line antituberculosis drugs was observed in other studies conducted in different provinces of Turkiye. The absence of multi-drug resistant and extensively drug-resistant tuberculosis in our study indicates that the tuberculosis surveillance program implemented in our region was successful.Öğe Evaluation of subclinical atherosclerosis in patients with psoriatic arthritis(Selçuk Üniversitesi, 2024) Atik, İrfan; Atik, Seda; Gül, EnesBackground/Aims: Psoriatic arthritis with peripheral and axial involvement; It is a heterogeneous disease that can cause enthesitis, dactylitis, and nail and skin involvement. The persistence of inflammation in psoriasis leads to comorbidities such as psoriatic arthritis, cardiovascular disease, and metabolic syndrome. Our study aimed to identify subclinical atherosclerosis in psoriatic arthritis patients without a known risk factor and to prevent possible morbidity and mortality in patients. Methods: Thirty-three patients with psoriatic arthritis and twenty-five healthy control groups were included in our study. Diabetes mellitus, hypertension, coronary artery disease, diagnosis of hyperlipidemia, body mass index above 30, and smoking were determined as exclusion criteria. The age, gender, duration of the disease, medical treatment used for the disease, high-density lipoprotein, low-density lipoprotein, triglyceride, and total cholesterol values, monocyte-lymphocyte ratio, carotid intima-media thickness measurement results obtained by carotid doppler ultrasonography imaging were recorded. Results: A comparison was made between the study and control groups in terms of age, triglyceride, high-density lipoprotein, low-density lipoprotein, and monocyte-lymphocyte ratio, and no statistically significant difference was observed. Monocyte and lymphocyte levels were significantly higher in the study group (p<0.05). Carotid intima-media thickness was statistically higher in the study group and this difference was statistically significant (p<0.05). Conclusions: Patients with psoriatic arthritis have an increased risk of atherosclerosis compared to the healthy population without any risk factors. This awareness will be useful in the follow-up of patients and in taking precautions against morbidities that may develop.Öğe Determination of factors affecting sleep quality in postoperative patients and ımprovement of correctible causes postoperatif(Selçuk Üniversitesi, 2024) Sert, Gökçe Selçuk; Kazancı, Dilek; Özgök, AyşegülPatients who had postoperative major abdominal surgery and major cardiovascular surgery were included in our study. A total of 103 patients were included in the study. Patients were evaluated with the Pitssburg sleep quality index questionnaire between five and seven days postoperatively. All questionnaires and scales were administered by the same researcher without specifying the participant’s name in order to maintain consistency. After explaining the scope and purpose of the study, written consent of all participants was obtained. Pittsburg sleep quality index is a 19-item self-report scale that evaluates sleep quality and disorder. It consists of 24 questions, 19 questions are self-report questions, 5 questions are questions to be answered by the spouse or roommate. The 18 scored questions of the scale consist of 7 components. Subjective Sleep Quality, Sleep Latency, Sleep Duration, Habitual Sleep Efficiency, Sleep Disorder, Sleeping Drug Use, and Daytime Dysfunction. Each component is evaluated over 0-3 points. The total score of the 7 components gives the scale total score. The total score ranges from 0 to 21. A total score greater than 5 indicates “poor sleep quality”. In our study, we aimed to investigate whether anesthetic agents, concomitant diseases, type of surgery, and some biochemical parameters affect sleep quality in postoperative patients. The diseases we investigated included hypertension, chronic obstructive pulmonary diseases, asthma, heart failure, cerebrovascular diseases, thyroid function disorders, diabetes mellitus, chronic kidney diseases, and chronic kidney failure. We also evaluated the sociocultural levels of the patients as an important part of the study. Educational status of our patients, literacy rates and occupations were also important to us. In our study, we showed that anesthetic agents [hypnotic and opioid] had no effect on sleep quality, and sleep quality was worse in cardiovascular surgery cases, although it was not statistically significant. We showed that a long operation time (5 hours and more) impairs postoperative sleep quality, thyroid diseases affect sleep quality badly, and sleep disorders are more common especially in patients with COPD. We think that sleep has a very important place in accelerating the recovery process of postoperative patients and that sleep disorders should be questioned better and that postoperative patients with sleep disorders should definitely seek psychological and medical help.Öğe Radiological imaging and analysis of laboratory values in case of acute ischemic stroke(Selçuk Üniversitesi, 2024) Alpaslan, Mustafa; Baykan, NecmiAim: The rate of death and disability due to acute ischemic stroke ranks second in the world. In this study it was planned to analyze the demographic characteristics and additional diseases in the etiology as well as radiological imaging and laboratory values in patients with ischemic stroke. Material Method: This study was conducted retrospectively by analyzing the patients hospitalized in the emergency department with the diagnosis of ischemic stroke between 01.01.2022 and 31.12.2022. Routine laboratory values, lipids, vitamin levels, radiological imaging and tests for etiology were analyzed in the patients. Results: One hundred seventy-seven patients were analyzed in the study. 53.1% of the patients were male. The mean age was 75±12.75 years. The most common comorbidities were hypertension, diabetes and hyperlipidemia. As ischemic infarction, involvement was most common in the areas fed by the middle cerebral artery. In the carotid and/or vertebral doppler ultrasonography performed in the patients, plaque was observed in the vessels at a rate of 83.1%. According to the transthoracic echocardiographic findings, 79.3% of the patients were found to have heart valve pathology. Pathologically the majority of patients had hyperglycemia, vitamin D deficiency and low HDL cholesterol levels. Thrombolytic therapy was applied in six patients and three patients benefited and one patient died due to bleeding. 13.6% of the patients were treated in the intensive care unit. Conclusion: The risk of ischemic stroke increases in advanced age. Hypertension and diabetes are among the most important risk factors. Vitamin D and vitamin B12 deficiency and folic acid deficiency pose a risk in terms of atherosclerosis. At the same time, low HDL cholesterol levels increase the risk of stroke. These factors which are considered as preventable causes in etiology should be controlled with treatment.Öğe Nasopharyngeal mucoepidermoid carcinoma: A rare case report(Selçuk Üniversitesi, 2024) Erdem, Rukiye Özçelik; Arbağ, Hamdi; Eryılmaz, Mehmet Akif; Dündar, Mehmet Akif; Arıcıgil, MitatIntroduction: Mucoepidermoid carcinoma is one of the common malignancies of the salivary glands. Nasopharyngeal mucoepidermoid carcinoma cases are rare. The treatment of these rare cases depends on the stage of the tumor and its invasion of the surrounding tissues. Case: The patient, who was diagnosed with thyroid papillary carcinoma in 2006 and was being followed up in medical oncology, applied to our clinic because of asymmetric thickening in the left nasopharynx, which was detected incidentally in the brain MRI. The patient had pain in the left neck area for about a month. Excisional biopsy of the lymph node with increased FDG uptake in the left jugulodigastric region on PET/CT and multiple punch biopsies from the nasopharynx were performed. The patient, whose pathology result was mucoepidermoid carcinoma, was referred to medical oncology to receive radiochemotherapy. Discussion: It should be kept in mind that, although rare, mucoepidermoid carcinoma may be present in patients presenting with a mass in the nasopharynx. Although studies conducted to date provide information on treatment options, prospective studies are needed for prognosis and treatment selection.
