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  • Öğe
    The Value of Immature Granulocyte and Immature Granulocyte/Total Granulocyte Ratio in Predicting the Need for Surgical Treatment in Patients Diagnosed with Intestinal Ileus in the Emergency Department
    (Selçuk Üniversitesi, 2023) Yaşar, Hakan; Emektar, Emine; Yıldırım, Meral; Çorbacıoğlu, Şeref Kerem; Çevik, Yunsur
    Objectives: Although many biomarkers that can predict the need for surgical treatment of patients with intestinal ileus have been investigated, effective, inexpensive, and fast-resulting biomarkers have not been determined. In our study, it was aimed to show the value of immature granulocyte (IG) and immature granulocyte/total granulocyte (IG/TG) ratio in predicting the need for surgical treatment in patients diagnosed with intestinal ileus in the emergency department. Method: Our study was carried out as a prospective cross-sectional. Patients aged 18 years and older admitted to the emergency department and diagnosed with intestinal ileus after clinical, laboratory and radiological evaluation were included in the study consecutively. Demographic characteristics, comorbidities, treatments, laboratory tests and IG, IG/TG results of the patients were recorded. The patients were divided into two groups as those who underwent surgical treatment and those who did not, and they were compared. p value <0.05 was considered statistically significant. Results: A total of 78 patients were included in the study. 46.2% (n=36) of the patients were female and the median age was 65 years. While surgery was performed in 41% (n=32) of the patients, 59% (n=46) were followed up with medical treatment. IG number and IG/TG ratio were found higher in patients who underwent surgical intervention than in those who underwent medical treatment, and these differences were statistically significant (p<0.05). In receiver-operating characteristic (ROC) analysis AUC: 0.658 was found for IG number. With the best cut-off value of 0.03, the sensitivity was 56.3% specificity: 71.7%; and the AUC value for IG/TG was: 0.627 (95% CI; 0.500-0.753), and when the best cut-off value was taken as 0.2, the sensitivity for this value was 59.4%, and the specificity was 63%. Conclusion: In this study, in which we examined the IG numbers and IG/TG ratios in patients with intestinal ileus, although we showed that these parameters were higher in patients who needed surgical treatment, upon the analysis done, we believe that it is not a clinically significant marker.
  • Öğe
    Vitamin D Status in Turkish Children During the Covid-19 Pandemic; A Single Center Experience
    (Selçuk Üniversitesi, 2023) Orhan Kılıç, Betül; Kılıç, Serhat; Gül Ateş, Eylem
    Objective: COVID-19-related lockdown decreased the children’s exposure to sunlight, and they were susceptible to 25-hydroxyvitamin D [25(OH)D] deficiency. The present study aimed to examine the 25(OH)D levels two years before and during the first year of the pandemic. Materials and Methods: Children whose Vitamin D levels were checked during well-child visits between October 2018 and March 2021 were included. Vitamin D levels were categorized according to the date vitamin D was checked; 2018 October 2019 March (Group 1), 2019 October, and 2020 March (Group 2), 2020 October, and 2021 March (Group 3). We compared the children’s 25(OH)D levels and vitamin D deficiency rates between Groups 1, 2, and 3. Results: We found that the mean of the children’s 25(OH)D levels was lower during COVID-19 than in the last two years before the pandemic (p=0.039). The present study showed that 25(OH) D deficiencies among ages 0-1 and 4-7 were higher during the pandemic than before (p= 0.013, p=0.011). Conclusion: Reduced sunbathing time during confinement is associated with lower 25(OH)D levels among children aged 4–7. Howeer, the increased rate of 25(OH)D deficiency in infants is worrying.
  • Öğe
    Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?
    (Selçuk Üniversitesi, 2023) Özer, Hakan; Zeybek Aydoğan, Kader; Öztürk, Yasin; Yönet, Fethi; Baloğlu, İsmail
    Background and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy. Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of diabetes. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is an essential indicator of inflammation and oxidative stress. In this study, we aimed to reveal the relationship between diabetes regulation and complications and MHR. Material and Method: A total of 182 subjects, including 152 patients with diabetes mellitus (DM) and 30 healthy controls, were included in this study. All data of the subjects were scanned retrospectively. The DM group was divided into two groups; nephropathy (n=68) and non-nephropathy (n=84), with a limit of 30 mg/day for albuminuria. MHR was calculated by dividing the monocyte count by the HDL cholesterol count. Results: When patients with DM were divided into nephropathy and non-nephropathy, patients with nephropathy had higher MHR levels than the other group. We showed that MHR correlated with albuminuria, creatinine, and HbA1c in patients with diabetic nephropathy. In addition, in the regression analysis, albuminuria and MHR were predictors of DN, while MHR, age, and creatinine were found as independent predictors of albuminuria. Conclusion: MHR, which is an easily calculated marker with simple laboratory tests and frequently requested in routine practice in the follow-up of diabetes patients, can help predict the regulation of diabetes and its kidney complications.
  • Öğe
    The Moderating Effect of Birth Satisfaction on the Correlation Between Mother-Infant Bonding and Psychological Resilience
    (Selçuk Üniversitesi, 2023) Karakayalı Ay, Çiğdem; Özşahin, Zeliha; Karataş Okyay, Esra
    Objectives: This study was conducted to evaluate the moderator effect of birth satisfaction in its correlation with mother-infant bonding and psychological resilience. Methods: This study was a descriptive study. The population of this study consisted of puerperal women who gave birth in a public hospital in Turkiye. The sample size was calculated as at least 437 puerperal women and included 491 puerperal women in total. Personal Introduction Form, the Brief Resilience Scale (BRS), Mother to Infant Bonding Scale (MIBS), and Birth Satisfaction Scale–Short Form (BSS–Short) were used to collect data. Results: Mean age of puerperal women included in this study was 28.07±5.17. The mean BSS-Short total score was 20.35±6.07, the mean MIBS total score was 1.73±2.44, and the mean BRS total score was 19.18± 4.50. In this study, it was determined that the correlation between birth satisfaction and mother-infant bonding increased as the level of psychological resilience increased. In addition to this, the simple slope analysis revealed that the effect of psychological resilience on mother-infant bonding was not significant in cases where birth satisfaction was high(B=-0.22, p=0.10) and the effect of psychological resilience on mother-infant bonding was significant in cases where birth satisfaction was moderate(B=-0.44,p=0.001) and high (B=-.71,p=0.001). Conclusion: It was concluded that the strength of the correlation between psychological resilience and mother-infant binding increased in cases where birth satisfaction was high.
  • Öğe
    Misdiagnosis of Bipolar Disorder: Rare or Frequent?
    (Selçuk Üniversitesi, 2023) Kaya, Şüheda; Taşcı, Gülay; Korkmaz, Sevda; Atmaca, Murad
    Background: Much as there have been limited number of studies which have examined misdiagnosis of bipolar disorder, it is so difficult to say that there is enough systematic research to identify the diagnostic rate of bipolar disorder. In our literature search, we could not find any study in our country about misdiagnoses before diagnosis of bipolar disorder. Therefore, we planned our study. Methods: The present study was done at xxx University, School of Medicine, Department of Psychiatry. Patients who were from both out-patient and in-patient clinics were included in the study. After a selection process, 171 patients with bipolar disorder were enrolled. In this group of patients, misdiagnosis of bipolar disorder were investigated. Results: Of the patients, 56.14 % had misdiagnosis of bipolar disorder. The most frequent misdiagnosis was fetermined to be major depressive disorder (in fifty cases, 54.3%). Followings were schizoaffective disorder (in 18 cases, 24.3%), schizophrenia (in 13 patients, 24.3%), delusional disorder (in 13 patients, 24.3%), dysthymic disorder (in 10 cases, 15.9%), generalized anxiety disorder ((in 10 cases, 15.9%), obsessive compulsive disorder (in seven cases, 12.6%), paranoid personality disorder (in two cases, 4.1%). Conclusions: The results of the study suggest that bipolar disorder is frequently misdiagnosed and that the most frequent misdagnoses were major depressive disorder and following psychotic spectrum disorders. Clinicians should be aware of frequent misdiagnosis in patients with bipolar disorder.
  • Öğe
    Alteration of Autonomic Nervous System Function in Male Patients with Overactive Bladder Syndrome
    (Selçuk Üniversitesi, 2023) Karasu, Betül Banu; Oruç, Ahmedi Uğur
    Background/Aims: Overactive bladder is a frequently encountered urological disease that has debilitating effects on quality of life. Some hypotheses have been put forward in order to explain the main pathophysiology underlying this clinical phenomenon, however, the exact mechanism remains unclear and the relevant reports are limited in number confined to female patients, and have conflicting results. Therefore, we aimed to examine one of these hypotheses -autonomic nervous system dysfunction- in male patients with overactive bladder. Methods: We included 41 male patients with overactive bladder and 43 healthy males in this study. Their electrocardiographic signals were recorded in the prevoiding and postvoiding periods and then converted to heart rate variability parameters which may reveal autonomic nervous system dysfunction. Results: Standard deviation of normal-to-normal interval, square root of the mean squared differences of successive normal-to-normal intervals, low frequency signal and low frequency/high frequency ratio were significantly lower while high frequency signal was significantly higher in the patient group compared to healthy controls (p<0.05). Conclusions: Heart rate variability was attenuated in male patients with overactive bladder and parasympathetic predominance was observed during both prevoiding and postvoiding periods, contrary to some of the previous reports revealing sympathetic predominance in female patients.
  • Öğe
    Serum Inflammatory Cytokines and Growth Factors in Patients with Sjögren’s Syndrome and Diabetes Mellitus
    (Selçuk Üniversitesi, 2023) Acar Duyan, Şule Nur; Bozkurt, Banu; Ünlü, Ali; Yılmaz, Sema; Karaküçük, Yalçın
    Purpose: Sjögren’s syndrome (SS) and diabetes mellitus (DM) are common causes of dry eye disease (DED) and autologous serum is used when artificial tears are not sufficient. Our aim was to compare serum growth factor and inflammatory cytokine levels of SS and DM patients with the healthy individuals. Methods: Twenty-three SS patients (mean age 52.70±7.55 years), 25 diabetic retinopathy (DR) patients (mean age 56.68±6.53 years), and 23 healthy subjects (mean age 51.70±9.14 years) were included in the study. After detailed ophthalmological examination, Schirmer test, tear break-up time (TBUT) and Ocular Surface Disease Index (OSDI) scores were measured. Serum levels of six different proinflammatory interleukins (IL), five growth factors, matrix metalloproteinase-9, and fibronectin were measured by immunoassay. One-way ANOVA or Kruskal-Wallis tests and DunnBonferroni post hoc analysis were used for comparison and p<0.05 was considered significant. Results: Schirmer test and TBUT were significantly lower in the SS group (2.08±1.72 mm/5 min and 3.08±2.08 s) than in the DR (10.24±4.63 mm/5 min and 4.20±3.09 s) and control groups (13.30±5.95 mm/5 min and 9.00±1.75 s) (p<0.001). Among the parameters studied, mean serum IL-23 level was significantly higher in the SS group (156.66±207.94 pg/mL) than in the DM and control groups (73.48±95.91 and 69.59±105.39 pg/mL, respectively) (p<0.05). Serum insulin-like growth factor 1 (IGF1) level was lowest in DM patients (DM: 12.89±21.09, SS: 30.77±19.85, and control: 27.08±21.93 ng/ mL) (p<0.05). Sjögren’s syndrome disease activity index (ESSDAI) showed a negative correlation with TBUT and a positive correlation with IL-1, IL-2 and fibronectin (p<0.005). Conclusion: Except IL-23 and IGF-1, the contents of serum obtained from patients with SS and DM are similar with the healthy individuals. Therefore, autologous serum seems to be a good option to replace deficient tear fluid in these subjects.
  • Öğe
    Juglone Effects by Dual Way on mTOR Gene Expression, Which Plays Central Role in Cell Growth, Survival and Metabolism, in PANC-1 and BxPC-3 Pancreatic Cancer Cell Lines
    (Selçuk Üniversitesi, 2023) Demirbaş Büyüktüt, Emine Merve; Erkoç Kaya, Dudu; Göktürk, Fatma; Arıkoğlu, Hilal
    Background/Aims: Juglone, as a naphthoquinone, has been shown to have cytotoxic and apoptotic effects in various cancer cells and besides this effects it was reported to have antiinvasive and anti-metastatic effects in PANC-1 and BxPC-3 cells in our previous studies. In this study, we investigated the effects of juglone on GRP75, TFAM and mTOR genes encoding key proteins associated with mitochondrial biogenesis and activation in PANC-1 and BxPC-3 pancreatic cancer cells since mitochondria have central roles in cancer cell survival, metastasis and therapeutic resistance. Methods: In our study; 5, 10, 15 and 20 ?M juglone doses were selected as the application doses considering the IC50 value determined after MTT test results and the expressions of the target genes were analyzed by qPCR method after application of juglone doses for 24 hours. Results: Our study results revealed that juglone had an opposite and strong effects on mTOR expression in both cell lines. Conclusion: Our findings suggest that juglone has a developable potential and is a promising theurapeutic agent to develop new strategies for the battle with cancer with those effects on mTOR gene which plays a central role in cellular homeostasis and several cellular events including cell growth, survival and metabolism.
  • Öğe
    Impact of Hemoglobin, Leucocyte and Thrombocyte Levels at Diagnosis on the Survival Outcomes of Chronic Myeloid Leukemia Patients
    (Selçuk Üniversitesi, 2024 Şubat) Demircioğlu, Sinan; Çiftçiler, Rafiye; Kars, Taha Ulutan; Tekinalp, Atakan
    Background: Since the development of tyrosine kinase inhibitors (TKIs), the prognosis for chronic myeloid leukemia (CML) has significantly improved. Several predicted prognostic scores and indicators at diagnosis have been used to predict the prognosis of chronic phase chronic myeloid leukemia (CML-CP) during the TKI period. When CML patients are first diagnosed, hemogram parameter aberrations are rather prevalent in clinical practice although it is still unknown how those parameters affect the prognosis. This study aims to evaluate the hemogram parameters at diagnosis on the survival outcomes of CML-CP patients. Materials and Methods: One hundred thirty-seven patients who were diagnosed with CML-CP and received treatment were assessed between the years 2006 and 2020. Results: There were 65 (47.4%) males and 72 (52.6%) females with a median age of 50 (range: 18-78) years at diagnosis. Median hemoglobin level was 12.1 gr/dL (4.3-17.4), leucocyte count was 66.2 ×109 /L (7.5-520.2), and thrombocyte count was 362 ×109 /L (18-3.496) for all patients. The median progression-free survival (PFS) was 16.7 (2.0-106.4) months and the median overall survival (OS) was 63.8 (0.43-166.2) months for all patients. Conclusion: This study is valuable in terms of predicting the prognosis of CML patients with hemoglobin, leukocyte, and platelet values at the time of diagnosis. While emphasizing the importance of platelet count at the time of diagnosis, similar to the previously defined risk scores, it showed that leukocyte and hemoglobin values at the time of diagnosis did not have a statistically significant effect on OS and PFS.
  • Öğe
    Is Less Surgical Treatment Possible in the Treatment of Degenerative Spine Diseases? Four-Year Follow-up Results of Foraminal Epidural and Facet Joint Injection Treatments
    (Selçuk Üniversitesi, 2024 Şubat) Ertem, Uğur
    ABSTRACT In this article, I would like to share my opinions about the article named ‘Is Less Surgical Treatment Possible in the Treatment of Degenerative Spine Diseases? Four-Year Follow-up Results of Foraminal Epidural and Facet Joint Injection Treatments’ (1). First of all, I would like to thank the authors. I will especially try to contribute to this article from the perspective of a physical medicine and rehabilitation physician.
  • Öğe
    Prescribing Drugs to Pregnant Women in Primary Healthcare
    (Selçuk Üniversitesi, 2024 Şubat) Fidancı, İzzet
    ABSTRACT It is crucial for the health of both the mother and the fetus that drugs are only used during pregnancy when absolutely necessary. While appropriate drugs can be used for appropriate indications during pregnancy, it is preferably recommended not to use medication except for the necessary vitamins. In cases where the drug is to be used, the pregnancy category of the medication to be used should be known for the selection of the appropriate medication. Drugs that we regularly prescribe because they are safe should be high on our list of preferences, and if there is chronic drug use, the use of drugs must be regulated with caution and constantly reviewed for appropriateness.
  • Öğe
    The Genetics of Parkinson’s Disease
    (Selçuk Üniversitesi, 2024 Şubat) Yücel, Zeliha; Şimşek, Levent; Yüksel, Emine Berrin
    ABSTRACT Parkinson’s disease (PD) is one of the most common neurodegenerative diseases worldwide. Approximately 15% of PD patients have a family history of the disease in one or more first-degree relatives, and 5-10% of PD cases exhibit a classical Mendelian inheritance pattern. In 1997, the heritable transmission of PD was first documented. Recent studies have found 90 independent genome-wide signals at 78 loci that may be associated with PD. The identification of genes linked to PD and their functions has uncovered novel biological pathways and treatment options that play a role in the development of PD. In this article, it is aimed to review up-to-date information on the genetics of PD.
  • Öğe
    Prevalence and Pattern of Cardiovascular Symptoms and Diseases in Pediatric Patients: Insights from a Single-Center Observational Study with a Focus on Age and Gender
    (Selçuk Üniversitesi, 2024 Şubat) Polat, Fuat; Kaya, Zeynettin
    ABSTRACT Background/Aims: This single-center, cross-sectional study aimed to investigate the prevalence and patterns of cardiovascular symptoms and findings among pediatric patients aged 1-18 years, focusing on age and gender as potential influencing factors. Methods: Pediatric patients aged 1-18 years with cardiovascular symptoms grouped as murmur, dyspnea, chest pain, palpitation, syncope and cyanosis were examined, categorized by age (1-6, 7-12, 13-18) and gender (male and female) using electronic medical records, undergoing comprehensive clinical assessments including examinations, ECGs, and echocardiograms. Statistical analyses unveiled prevalence trends. Results: 720 patients were included in the study and 53.9% of them were female. The prevalence of symptoms and diseases varied by age. Chest pain was more common in 13-18 group; cardiac murmurs linked to congenital defects were more common in 1-6 group; valve and pericardial/ myocardial diseases were more common in the 7-12 age group. Gender had no significant effect on disease patterns. Conclusion: The study emphasizes the importance of age-appropriate management and personalized management in cardiovascular diseases. Gender did not have a significant role in terms of cardiovascular diseases.
  • Öğe
    Comparison of Physicians’ Perceptions Regarding Dermatological Diseases
    (Selçuk Üniversitesi, 2024 Şubat) Aksoy, Hasan; Aslan Kayıran, Melek
    ABSTRACT Background/Aims: Physicians frequently encounter skin diseases and provide opinions to their patients regarding dermatology. We aimed to assess the perceptions of physicians regarding skin diseases and to compare dermatologists’ and non-dermatologist physicians’ understanding of specific dermatological issues. Methods: Through an online form, participants were asked to respond to sentences indicating whether skin diseases are related to the liver or food with options such as “almost always,” “mostly,” “half-and-half,” “less often,” and “almost never.” Similarly, they were asked to respond to sentences related to avoiding isotretinoin treatment, the tendency of dermatologists to use corticosteroids, and performing allergy tests in acute urticaria with options as “strongly disagree,” “disagree,” “partly agree,” “agree,” and “strongly agree.” Results: The sentences “skin diseases are of liver origin” and “skin diseases are caused by foods/ drinks” received responses of “almost never” or “less often” at a rate of 91.8% and 80.9%, respectively. The total proportions of participants who selected “strongly agree,” “agree,” or “partly agree” were 53.9% for the statement restricting isotretinoin use and 45.5% for the statement recommending allergy testing in acute urticaria. While 91.8% of dermatologists disagreed with the statement limiting isotretinoin use, 68.3% of non-dermatologist physicians partially or completely agreed. For the statement recommending allergy testing in acute urticaria, 85.8% of dermatologists disagreed, while 55.7% of non-dermatologist physicians partially or completely agreed. Conclusions: The popular belief that skin diseases are caused by the liver or food has no basis among physicians. However, contrary to the literature, non-dermatologist physicians have expressed opinions that isotretinoin should be used as little as possible due to potential harm to the liver and that allergy tests should be performed in cases of acute urticaria. Giving importance to these topics during medical education will contribute to changing physicians’ perspectives and ultimately benefit public health.
  • Öğe
    Lessons Learned from Crisis Management and Amputation Decisions in the Aftermath of High-magnitude Earthquakes in Kahramanmaras on 6 February 2023
    (Selçuk Üniversitesi, 2024 Şubat) Orhan, Atilla
    ABSTRACT Introduction: Earthquakes of high magnitude and prolonged duration result in catastrophic events, causing significant loss of life and property. Immediate medical interventions become crucial in the aftermath of such disasters to prevent long-term disabilities and fatalities. This study focuses on the challenges faced by a volunteer medical team in Kahramanmaras, Turkiye, after two major earthquakes struck on February 6, 2023, affecting millions of people. Methods: A team of 35 experienced medical professionals, led by a cardiothoracic surgeon, was dispatched to the disaster site. The team’s schedule, tasks, and logistical details were organized to optimize their response. The study outlines the methods employed by the team to assess and treat extremity traumas, including amputations during the first-week post-earthquake. Results: The earthquake severely impacted local healthcare facilities, resulting in inadequate patient management, insufficient medical personnel, and logistical difficulties. The volunteer team worked tirelessly, performing surgeries and amputations and providing medical equipment. A total of 16 lower limb amputations and two upper limb amputations were performed due to severe extremity crush injuries. Discussion: The chaotic conditions post-earthquake revealed challenges in managing crush syndrome patients. The study discusses the decision-making process for amputations, fasciotomies and patient transfers. Despite limited facilities, the team restored the hospital to full functionality within a few days. Conclusion: The study concludes that volunteer healthcare teams are crucial in disaster response. Effective organization, communication, and logistics are essential for optimal performance. Continuous training on disaster scenarios for volunteer teams is recommended. The importance of restoring healthcare facilities to routine operation after immediate crisis response is emphasized, as well as the need for comprehensive scientific data to understand the extent of the disaster’s impact.
  • Öğe
    Assessment of the Opinions of Anesthesiology and Reanimation Research Assistants Regarding Clinical Anatomy Education: A University Example
    (Selçuk Üniversitesi, 2024 Şubat) Aslanlar, Emine; Kara, İnci; Doğan, Nadire Ünver; Fazlıoğulları, Zeliha; Büyükcavlak, Mustafa
    ABSTRACT Introduction: Anatomy is considered one of the cornerstones of medical education. In-depth understanding of anatomy is essential, especially for safe clinical practice in surgical disciplines. This study aimed to evaluate the feedback of research assistants in the department of anesthesiology and reanimation, who received clinical anatomy education. Methods: Clinical anatomy education was provided for research assistants at different levels in the department of anesthesiology and reanimation, with two hours per week, and the education was completed within one month. The 5-point Likert scale questionnaire consisting of 18 questions was administered to research assistants to gather their opinions about education. Participants were asked to rate the questions on a scale from 1 to 5. Additionally, data such as age, gender, duration of clinical experience, experience with neuroaxial or peripheral nerve blocks, and participation in regional anesthesia courses were recorded. Results: A total of 40 participants, including 15 (37.5%) males and 25 (62.5%) females, with an average age of 29.67 ± 3.94 years, were included in the study. Nearly all participants in our study reported that integrated clinical anatomy education is necessary. The majority mentioned that anatomy education would contribute to airway management and regional anesthesia applications. The participation rate in regional anesthesia courses before education was 17.5%. There was no significant difference in average questionnaire scores between those who participated in regional anesthesia courses and those who did not (p=0.06). Conclusion: In the process of anesthesiology and reanimation specialization training, we believe that incorporating clinical anatomy education would enhance the quality of specialization education, thereby improving safety and effectiveness in clinical applications.
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    Dosimetric Comparison of Inverse Planning Simulated Annealing and Manual Optimization for Intracavitary Cervix Brachytherapy
    (Selçuk Üniversitesi, 2024 Şubat) Başaran, Hamit; Düzova, Mürsel; İnan, Gökçen; Gül, Osman Vefa
    Background/Aims: Different optimization methods in brachytherapy treatment planning have been used. The aim of this study is to evaluate dosimetric differences between manual optimization (MO) and inverse planning simulated annealing (IPSA) planning techniques commonly used in brachytherapy of cervical cancer. Methods: Fifteen cervical cancer patients were included in this study. Nucletron standard tandemovoid (TO) applicators were used for treatment. High-risk clinical tumor volume (HR-CTV), bladder, rectum and sigmoid contouring were performed according to GEC-ESTRO recommendations. Two plans were created for each patient using IPSA and MO techniques. While a dose of 700 cGy was prescribed to the target volume during the planning phase, an effort was made to protect the organs at risk in the best way possible. IPSA and MO planning techniques were compared via dose volume histogram (DVH). Results: There was no significant difference between HR-CTV and CI values for MO and IPSA techniques. There was a significant difference between IPSA and MO techniques for the 2cm3 volume of the rectum (p= 0.002). It was observed that the bladder was better protected by the IPSA technique. There was a 6.26% dose difference between IPSA and MO for the bladder. A significant difference was found between IPSA and MO techniques for the 2cm3 volume of the sigmoid (p= 0.002). The IPSA technique was superior to the MO technique in terms of time. Conclusions: The IPSA technique was superior to the MO technique in terms of protecting organs at risk (OARs). IPSA provides a faster and higher quality plan in cervical brachytherapy. Keywords: Brachytherapy, Cervix cancer, IPSA
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    The Relationship Between Type D Personality, Bedtime Procrastination and Sleep Quality
    (Selçuk Üniversitesi, 2024 Şubat) Uygur, Hilal; Demiröz, Dudu; Uygur, Ömer Faruk; Duman, Ayşe
    ABSTRACT Background/Aims: Bedtime procrastination (BP) is an unhealthy sleep behavior, but its relationship with Type D (distress) personality has never been examined. This study aimed to investigate the relationship between Type D Personality, BP, and Sleep Quality in university students. Methods: In this cross-sectional study, we applied the sociodemographic sleep data form, Type D personality scale (DS-14), Bedtime Procrastination Scale (BPS), Pittsburgh Sleep Quality Index (PSQI) (subjective sleep quality and daytime dysfunction subscales), Insomnia Severity Index (ISI), and Epworth Sleepiness Scale (ESS). All participants were divided into two groups: Type D personality and non-Type D personality. Sleep variables and scales were compared between these two groups. Additionally, correlation analysis was performed between the scales and the subdimensions of Type D personality. Results: We completed our study with 209 university students (66%, n = 138 female and 34%, n=71 male). The mean age was 22.17 ± 4.33, and 51.2% of the participants had Type D personality. Sleep quality was poor and insomnia was more severe in participants with Type D personality. Participants with Type D personality had more delayed bedtime. Negative affectivity was associated with poor sleep quality, more severe insomnia and BP, but social inhibition was not associated with BP. Conclusion: Clinicians should consider the negative affectivity sub-dimension of Type D personality contributing to BP behavior among university students when planning interventions to reduce BP behavior
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    The Incidence and Risk Factors for the Presence of Type 1B or Type 3 Utero-ovarian Anastomoses During Uterine Artery Embolization
    (Selçuk Üniversitesi, 2024 Şubat) Çay, Ferdi; Eldem, Gonca; Çil, Barbaros Erhan; Peynircioğlu, Bora
    ABSTRACT Background/Aims: Demonstration of possible utero-ovarian anastomoses (UOA) before or during uterine artery embolization (UAE) is important to preserve ovarian reserve. This study aimed to evaluate the incidence and risk factors for the presence of type 1b or type 3 UOA in patients undergoing UAE for the treatment of uterine myomas. Methods: Procedural angiographies of patients who underwent UAE were evaluated in a single academic center. Patients’ demographics, indication for UAE, presence and type of UOA, presence of adnexal pathology at preprocedural MRI, history of pelvic surgery, and total uterine volume at preprocedural MRI were retrospectively evaluated. Analysis of the aforementioned variables between patients with and without UOA was performed. Results: This study included 30 patients with a mean age of 41.97±5.72 years (range 32 - 56). UOA was found in 17 (56.6%) patients, 10 (33.3%) of them were type 1b, and 7 (23.3%) of them were type 3. Five patients (17.2%) had adnexal pathology at pre-procedural MRI and 12 patients (40%) had a history of pelvic surgery. The mean total uterine volume was 607.1 cm3. In the analysis of variables between patients with and without UOA, UOA presence was significantly higher in patients with a history of pelvic surgery (p=0.005). All of the patients with a history of myomectomy were found to have type 1b or type 3 UOA. No significant relation between UOA and age, the presence of adnexal pathology, and uterine volume were detected. Conclusion: Utero-ovarian anastomoses are commonly encountered during UAE. A history of pelvic surgery was found to be a risk factor for the presence of type 1b and type 3 UOA.
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    Cytokine Response to Acute Endurance Exercise: Regular Treadmill versus Lower Body Positive Pressure Treadmill
    (Selçuk Üniversitesi, 2024 Şubat) Kırışka, Muhammet Salih; Belviranlı, Muaz; Okudan, Nilsel
    ABSTRACT Objectives: This study aimed to investigate the cytokine response to acute endurance exercise performed in the lower body positive pressure treadmill (LBPPT) and to compare it with the regular treadmill. Materials and Methods: Eleven healthy physically active men aged between 18-22 years participated in the study. All subjects performed 45 minutes of running exercise at 70% maximal oxygen consumption (VO2max) on the regular treadmill and LBPPT in random order, one week apart. Blood samples were collected at pre-exercise, immediately post-exercise, 30 min postexercise, and 2 h post-exercise to analyze serum high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-?), and interleukin-8 (IL-8) levels. Results: On the regular treadmill, hs-CRP levels were higher immediately, 30 min, and 2 h postexercise than pre-exercise. In addition, it was lower 2 h post-exercise compared with immediately, and 30 min post-exercise. No significant differences in LBPPT for hs-CRP were observed for any time point. Hs-CRP concentration immediately and 30 min post-exercise was lower in the LBPPT than in the regular treadmill. TNF-? and IL-8 levels were unchanged in response to exercise performed neither on the regular treadmill nor on the LBPPT. Conclusion: Acute endurance exercise induces a limited systemic inflammatory response in physically active men.