Yazar "Ökesli, S." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    The Effects of Repeated Sevoflurane Anaesthesia on Neonatal Rat Liver: the Role of Soda Lime [Tekrarlayan Sevofluran Anestezisinin Yavru Rat Karaciğeri Üzerine Etkileri: Sodalaym'in Rolü]
    (2003) Ünal, M.; Reisli, Ruhiye; Tuncer, Sema; Erol, Atilla; Avunduk, M.; Ökesli, S.
    Experimental studies indicate that repeated exposure to sevoflurane can be hepatotoxic. It may be either related with direct effect of this anaesthetic agent or with the degradation of sevoflurane by soda lime which is also known to produce toxic products. The aim of this study was to investigate the effects of repeated sevoflurane anaesthesia on liver in neonatal rats with or without soda lime. Twenty seven rats were used in the experiment (15-30 g weight). The rats were randomly divided into three groups (9 each). The rats were placed in a specially prepared transparant plastic box. Group C was the control group. They received 100% O2. In the anaesthesia circle without sodalime sevoflurane in 2.5-2.7 % concentration with O2 (100%) were administered directly in group S, while the same gas mixture was applied through the soda lime in group, SS. Repeated anaesthesia (five times) was applied to the rats for sixty minutes with two days intervals. SGOT, SGPT and ALP levels were measured from the blood samples. Following sacrifice on the day ten, liver tissue samples were examined using light microscopy for histopathological evaluation. SGOT, SGPT and ALP levels were increased especially in group SS. There were only minimal changes in histopathological evaluation of liver from both experimental groups which were not statistically significant. As a result repeated sevoflurane anaesthesia with or without sodalime has minimal effects on liver.
  • Küçük Resim Yok
    Öğe
    The Maternal and Neonatal Effects of Intrathecal Sufentanil and Fentanyl Added to Hyperbaric Bupivacaine for Cesarean Section [Sezaryenlerde Bupivakaine Eklenen Sufentanil ve Fentanilin Maternal ve Neonatal Etkileri]
    (2003) Reisli, Ruhiye; Tuncer, Sema; Çelik, J.; Yosunkaya, Alper; Uzun, S.; Sarkılar, Gamze; Ökesli, S.
    We aimed to evaluate the maternal and neonatal effects of intrathecal sufentanil, fentanyl and plasebo added to hyperbaric bupivacaine for cesarean section. After etthical committee approval, 45 healty, full-term parturients allocated into three groups. Group K (control group) received 10 mg bupivacaine heavy and 2 cc % 0.9 NaCl, Group F received 10 mg bupivacaine heavy and 25 ?g fentanyl and Group S received 10 mg bupivacaine heavy and 10 pg sufentanil intrathecally, Total volume of 4 mL was used in both groups. Haemodynamic values, sensory and motor blocs, the first requirement time for analgesia and Intrapostoperative side effects were recorded. Blood samples were collected from the umblical artery for blood gas analyses. Apgar score at 1 and 5 min. and Neurologic and Adaptive Capacity Score (NACS) of newborns at 2 evaluated. There were no significant differences in patients characteristics, time to reach L1-2, T10 and maximal sensory level, degree and resolution of motor block, blood gas analyses, Apgar and NACS scores. Nausea was more in group K than in group S and F (p<0.05). Pruritus was a frequent side effect both in group S and F (p<0.05), but it was more remarkable in group S (p<0.05). Complete analgesia was prolong in group F and S than in group K. The first requirement time for analgesia was longer in group S compared to group F (p<0.05). In summary, intrathecal fentanyl 25 pg or sufentanil 10 ?g added to hyperbaric bupivacaine for cesarean section reduced nausea and increased the duration of analgesia in the early postoperative period. Because this combinations had no adverse effects oil neonatals we concluded that they can be used safely in cesarean sections.