The Effects of Repeated Sevoflurane Anaesthesia on Neonatal Rat Liver: the Role of Soda Lime [Tekrarlayan Sevofluran Anestezisinin Yavru Rat Karaciğeri Üzerine Etkileri: Sodalaym'in Rolü]
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Experimental studies indicate that repeated exposure to sevoflurane can be hepatotoxic. It may be either related with direct effect of this anaesthetic agent or with the degradation of sevoflurane by soda lime which is also known to produce toxic products. The aim of this study was to investigate the effects of repeated sevoflurane anaesthesia on liver in neonatal rats with or without soda lime. Twenty seven rats were used in the experiment (15-30 g weight). The rats were randomly divided into three groups (9 each). The rats were placed in a specially prepared transparant plastic box. Group C was the control group. They received 100% O2. In the anaesthesia circle without sodalime sevoflurane in 2.5-2.7 % concentration with O2 (100%) were administered directly in group S, while the same gas mixture was applied through the soda lime in group, SS. Repeated anaesthesia (five times) was applied to the rats for sixty minutes with two days intervals. SGOT, SGPT and ALP levels were measured from the blood samples. Following sacrifice on the day ten, liver tissue samples were examined using light microscopy for histopathological evaluation. SGOT, SGPT and ALP levels were increased especially in group SS. There were only minimal changes in histopathological evaluation of liver from both experimental groups which were not statistically significant. As a result repeated sevoflurane anaesthesia with or without sodalime has minimal effects on liver.
Açıklama
Anahtar Kelimeler
Hepatotoxicity, Neonatal Rat, Sevoflurane, Soda Lime
Kaynak
Türk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
31
Sayı
1
Künye
Ünal, M., Reisli, R., Tuncer, S., Erol, A., Avunduk, M., Ökesli, S., (2003). The Effects of Repeated Sevoflurane Anaesthesia on Neonatal Rat Liver: the Role of Soda Lime [Tekrarlayan Sevofluran Anestezisinin Yavru Rat Karaciğeri Üzerine Etkileri: Sodalaym'in Rolü]. Türk Anesteziyoloji ve Reanimasyon, 31(1), 14-20.
